| dbo:abstract |
Die cccDNA (von eng. covalently closed circular DNA) ist eine besondere DNA-Struktur, die während der Vermehrung einiger Viren im Zellkern auftritt und dort dauerhaft verbleiben kann. Die cccDNA ist eine doppelsträngige DNA, die aus einer linearen Form mithilfe einer DNA-Ligase zu einem kovalent geschlossenen Ring überführt wurde. Meist kann erst von dieser cccDNA die Transkription der viralen mRNA erfolgen. Die cccDNA von Viren wird auch als episomale DNA oder selten als bezeichnet. (de) cccDNA (covalently closed circular DNA) is a special DNA structure that arises during the propagation of some viruses in the cell nucleus and may remain permanently there. It is a double-stranded DNA that originates in a linear form that is ligated by means of DNA ligase to a covalently closed ring. In most cases, transcription of viral DNA can occur from the circular form only. The cccDNA of viruses is also known as episomal DNA or occasionally as a minichromosome. cccDNA was first described in bacteriophages, but it was also found in some cell cultures where an infection of DNA viruses (Polyomaviridae) was detected. cccDNA is typical of Caulimoviridae and Hepadnaviridae, including the hepatitis B virus (HBV). cccDNA in HBV is formed by conversion of capsid-associated relaxed circular DNA (rcDNA). Following hepatitis B infections, cccDNA can remain following clinical treatment in liver cells and can rarely reactivate. The relative quantity of cccDNA present is an indicator for HBV treatment. (en) Il DNA circolare chiuso covalentemente (covalently closed circular DNA o cccDNA) è un particolare tipo di struttura del DNA che si forma durante la propagazione di alcuni virus nel nucleo cellulare e può rimanere perennemente.È un DNA a doppio filamento che viene originato da un iniziale doppio filamento lineare che viene legata tramite una DNA ligasi in modo da formare un anello chiuso.Nella maggior parte dei casi, la trascrizione del DNA virale può avvenire solo se questi è nella sua forma circolare.Il cccDNA dei virus è anche conosciuto come DNA episomale o minicromosoma. Tra i virus che utilizzano il ccDNA vi è l'HBV. (it) cccDNA即共价闭合环状DNA (covalently closed circular DNA)是一种有三级结构的双链环状DNA分子，最早是在噬菌体中发现的，而在自然界中被DNA病毒（如多瘤病毒科）感染的其它细胞中也有发现。 (zh) |
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| rdfs:comment |
Die cccDNA (von eng. covalently closed circular DNA) ist eine besondere DNA-Struktur, die während der Vermehrung einiger Viren im Zellkern auftritt und dort dauerhaft verbleiben kann. Die cccDNA ist eine doppelsträngige DNA, die aus einer linearen Form mithilfe einer DNA-Ligase zu einem kovalent geschlossenen Ring überführt wurde. Meist kann erst von dieser cccDNA die Transkription der viralen mRNA erfolgen. Die cccDNA von Viren wird auch als episomale DNA oder selten als bezeichnet. (de) cccDNA即共价闭合环状DNA (covalently closed circular DNA)是一种有三级结构的双链环状DNA分子，最早是在噬菌体中发现的，而在自然界中被DNA病毒（如多瘤病毒科）感染的其它细胞中也有发现。 (zh) cccDNA (covalently closed circular DNA) is a special DNA structure that arises during the propagation of some viruses in the cell nucleus and may remain permanently there. It is a double-stranded DNA that originates in a linear form that is ligated by means of DNA ligase to a covalently closed ring. In most cases, transcription of viral DNA can occur from the circular form only. The cccDNA of viruses is also known as episomal DNA or occasionally as a minichromosome. (en) Il DNA circolare chiuso covalentemente (covalently closed circular DNA o cccDNA) è un particolare tipo di struttura del DNA che si forma durante la propagazione di alcuni virus nel nucleo cellulare e può rimanere perennemente.È un DNA a doppio filamento che viene originato da un iniziale doppio filamento lineare che viene legata tramite una DNA ligasi in modo da formare un anello chiuso.Nella maggior parte dei casi, la trascrizione del DNA virale può avvenire solo se questi è nella sua forma circolare.Il cccDNA dei virus è anche conosciuto come DNA episomale o minicromosoma. (it) |
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CccDNA (de) CccDNA (en) CccDNA (it) CccDNA (zh) |
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