| dbo:abstract |
SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function. TAg is a product of an early gene transcribed during viral infection by SV40, and is involved in and regulation of host cell cycle. SV40 is a double-stranded, circular DNA virus belonging to the Polyomaviridae (earlier Papovavirus) family, genus. Polyomaviruses infect a wide variety of vertebrates and cause solid tumours at multiple sites. SV40 was isolated by Sweet and Maurice Hilleman in 1960 in primary monkey kidney cell cultures being used to grow Sabin OPV. (en) SV40大T抗原（英语：SV40 large T antigen或Simian Vacuolating Virus 40 TAg）是一种六聚体蛋白，是源自多瘤病毒科SV40的显性作用癌蛋白。TAg能够诱导多种细胞类型的恶性转化。 TAg的转化活性在很大程度上是由于其对视网膜母细胞瘤（pRb）的干扰和p53肿瘤抑制蛋白。此外，TAg与其他几种细胞因子结合，包括转录共激活因子，这可能有助于其转化功能。 TAg是SV40在病毒感染过程中转录的早期基因产物，参与病毒基因组复制和宿主细胞周期调控。 SV40是一种双链环状DNA病毒，属于多瘤病毒科（早期的 Papovavirus）家族，Orthopolyomavirus属。多瘤病毒感染多种脊椎动物并在多个部位引起实体瘤。 SV40由Sweet B.H.和莫里斯·希勒曼于1960年在用于生长沙宾OPV的原代猴肾细胞培养物中分离出来。 (zh) |
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| dbp:caption |
SV40 T helicase domain hexamer, Simian virus. (en) |
| dbp:organism |
Simian virus 40 (en) |
| dbp:uniprot |
P03070 (en) |
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| gold:hypernym |
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| rdfs:comment |
SV40大T抗原（英语：SV40 large T antigen或Simian Vacuolating Virus 40 TAg）是一种六聚体蛋白，是源自多瘤病毒科SV40的显性作用癌蛋白。TAg能够诱导多种细胞类型的恶性转化。 TAg的转化活性在很大程度上是由于其对视网膜母细胞瘤（pRb）的干扰和p53肿瘤抑制蛋白。此外，TAg与其他几种细胞因子结合，包括转录共激活因子，这可能有助于其转化功能。 TAg是SV40在病毒感染过程中转录的早期基因产物，参与病毒基因组复制和宿主细胞周期调控。 SV40是一种双链环状DNA病毒，属于多瘤病毒科（早期的 Papovavirus）家族，Orthopolyomavirus属。多瘤病毒感染多种脊椎动物并在多个部位引起实体瘤。 SV40由Sweet B.H.和莫里斯·希勒曼于1960年在用于生长沙宾OPV的原代猴肾细胞培养物中分离出来。 (zh) SV40 large T antigen (Simian Vacuolating Virus 40 TAg) is a hexamer protein that is a dominant-acting oncoprotein derived from the polyomavirus SV40. TAg is capable of inducing malignant transformation of a variety of cell types. The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor proteins. In addition, TAg binds to several other cellular factors, including the transcriptional co-activators p300 and CBP, which may contribute to its transformation function. (en) |
| rdfs:label |
SV40 large T antigen (en) SV40大T抗原 (zh) |
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