| dbo:abstract |
Clevidipin ist ein Arzneistoff (ein Dihydropyridin-L-Typ-Calciumkanalblocker) aus der Gruppe der Calciumantagonisten zur raschen Reduktion eines erhöhten Blutdrucks in perioperativen Situationen. Die Substanz wurde in den USA im Jahr 2008 und in der Schweiz 2010 zugelassen. (de) Clevidipine (INN, trade name Cleviprex) is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable. Clevidipine is used IV only and practitioners titrate this drug to lower blood pressure. It has a half-life of approximately one minute. It is rapidly inactivated by esterases. It was approved by the United States Food and Drug Administration on August 1, 2008. (en) La clévidipine est un inhibiteur calcique de type dihydropyridine, utilisé comme médicament intraveineux dans les poussées hypertensives. (fr) Klewidypina (łac. clevidipinum) – wielofunkcyjny organiczny związek chemiczny z grupy pirydyn, lek stosowany w leczeniu nadciśnienia tętniczego, o działaniu blokującym kanały wapniowe typu L. Jest związkiem chiralnym, produkt farmaceutyczny jest mieszaniną racemiczną obu enancjomerów. (pl) |
| dbo:alternativeName |
Cleviprex (en) |
| dbo:bioavailability |
100.000000 (xsd:float) |
| dbo:casNumber |
167221-71-8 |
| dbo:chEMBL |
1237132 |
| dbo:fdaUniiCode |
19O2GP3B7Q |
| dbo:pubchem |
153994 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/(RS)-Clevidipin_Structural_Formula_V1.svg?width=300 |
| dbo:wikiPageExternalLink |
http://ir.themedicinescompany.com/phoenix.zhtml%3Fc=122204&p=irol-newsArticle&ID=1182776&highlight= http://www.cleviprex.com/pdfs/cleviprex-us-prescribing-information-nov-fda-approved.pdf https://web.archive.org/web/20160309003355/http:/www.cleviprex.com/pdfs/cleviprex-us-prescribing-information-nov-fda-approved.pdf |
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| dbp:atcPrefix |
8.0 |
| dbp:atcSuffix |
CA16 (en) |
| dbp:bioavailability |
100.0 |
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167221 (xsd:integer) |
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1237132 (xsd:integer) |
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135722 (xsd:integer) |
| dbp:chirality |
dbr:Racemic_mixture |
| dbp:cl |
2 (xsd:integer) |
| dbp:dailymedid |
Clevidipine (en) |
| dbp:eliminationHalfLife |
60.0 |
| dbp:excretion |
dbr:Feces dbr:Urine |
| dbp:h |
23 (xsd:integer) |
| dbp:image |
Clevidipine 3D.png (en) |
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-5 (xsd:integer) |
| dbp:legalEu |
Rx-only (en) |
| dbp:legalUs |
Rx-only (en) |
| dbp:metabolism |
Blood and tissue esterases (en) |
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1 (xsd:integer) |
| dbp:o |
6 (xsd:integer) |
| dbp:proteinBound |
>99.5% (en) |
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153994 (xsd:integer) |
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dbr:Intravenous_therapy |
| dbp:smiles |
O=C\C1=CC (en) |
| dbp:tradename |
Cleviprex (en) |
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19 (xsd:integer) |
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| dcterms:subject |
dbc:Carboxylate_esters dbc:Chloroarenes dbc:Dihydropyridines dbc:Formals dbc:Butyrate_esters dbc:Calcium_channel_blockers |
| gold:hypernym |
dbr:Blocker |
| rdf:type |
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| rdfs:comment |
Clevidipin ist ein Arzneistoff (ein Dihydropyridin-L-Typ-Calciumkanalblocker) aus der Gruppe der Calciumantagonisten zur raschen Reduktion eines erhöhten Blutdrucks in perioperativen Situationen. Die Substanz wurde in den USA im Jahr 2008 und in der Schweiz 2010 zugelassen. (de) Clevidipine (INN, trade name Cleviprex) is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable. Clevidipine is used IV only and practitioners titrate this drug to lower blood pressure. It has a half-life of approximately one minute. It is rapidly inactivated by esterases. It was approved by the United States Food and Drug Administration on August 1, 2008. (en) La clévidipine est un inhibiteur calcique de type dihydropyridine, utilisé comme médicament intraveineux dans les poussées hypertensives. (fr) Klewidypina (łac. clevidipinum) – wielofunkcyjny organiczny związek chemiczny z grupy pirydyn, lek stosowany w leczeniu nadciśnienia tętniczego, o działaniu blokującym kanały wapniowe typu L. Jest związkiem chiralnym, produkt farmaceutyczny jest mieszaniną racemiczną obu enancjomerów. (pl) |
| rdfs:label |
Clevidipine (en) Clevidipin (de) Clévidipine (fr) Klewidypina (pl) |
| owl:sameAs |
freebase:Clevidipine yago-res:Clevidipine wikidata:Clevidipine dbpedia-de:Clevidipine dbpedia-fa:Clevidipine dbpedia-fr:Clevidipine dbpedia-pl:Clevidipine dbpedia-ro:Clevidipine dbpedia-sh:Clevidipine dbpedia-sr:Clevidipine https://global.dbpedia.org/id/4i19n |
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wikipedia-en:Clevidipine?oldid=1098432804&ns=0 |
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wikipedia-en:Clevidipine |
| is dbo:wikiPageRedirects of |
dbr:C21H23Cl2NO6 dbr:ATC_code_C08CA16 dbr:ATCvet_code_QC08CA16 dbr:Clevidipine_butyrate dbr:Cleviprex |
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dbr:Antihypertensive_drug dbr:Calcium_channel_blocker dbr:C21H23Cl2NO6 dbr:Dihydropyridine_calcium_channel_blockers dbr:ATC_code_C08CA16 dbr:ATCvet_code_QC08CA16 dbr:ATC_code_C08 dbr:Retrometabolic_drug_design dbr:List_of_drugs:_Cj–Cl dbr:Clevidipine_butyrate dbr:Cleviprex |
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wikipedia-en:Clevidipine |
