| dbo:abstract |
Dermonekrotisches Toxin (DT) ist ein Protein aus Bordetella sp. und ein mikrobielles Exotoxin. (de) In molecular biology, the cytotoxic necrotising factor family of proteins includes bacterial cytotoxic necrotising factor proteins and the related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) is a toxin whose structure from Escherichia coli revealed a 4-layer alpha/beta/beta/alpha structure containing mixed beta-sheets. CNF1 is expressed in strains of E. coli causing uropathogenic and neonatal meningitis. CNF1 alters host cell actin cytoskeleton and promotes bacterial invasion of the blood–brain barrier endothelial cells. CNF1 belongs to a unique group of large cytotoxins that cause constitutive activation of Rho guanosine triphosphatases (GTPases), which are key regulators of the actin cytoskeleton . Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho. DNT is an A-B toxin composed of an N-terminal receptor-binding (B) domain and a C-terminal enzymatically active (A) domain. (en) |
| dbo:symbol |
CNF1 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/PDB_1hzg_EBI.jpg?width=300 |
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dbr:Proteins dbr:Cytoskeleton dbr:Deamidation dbr:Meningitis dbr:Gene_expression dbr:Endothelial_cell dbr:Enzyme dbr:Bacteria dbr:Bacterial dbr:Actin dbr:Cell_(biology) dbr:Cytotoxic dbr:Escherichia_coli dbr:Focal_adhesion dbr:Protein_domain dbr:Protein dbc:Protein_domains dbr:Guanosine dbr:Blood–brain_barrier dbr:Toxin dbr:Bordetella dbr:Cytotoxins dbr:RHOA dbr:Species dbr:Secondary_structure dbr:Gene_activation dbr:Necrotizing dbr:Beta-sheet dbr:Neonatal |
| dbp:caption |
866.0 |
| dbp:interpro |
IPR008430 (en) |
| dbp:name |
CNF1 (en) |
| dbp:pfam |
PF05785 (en) |
| dbp:scop |
1 (xsd:integer) |
| dbp:symbol |
CNF1 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist |
| dcterms:subject |
dbc:Protein_domains |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 dbo:Protein |
| rdfs:comment |
Dermonekrotisches Toxin (DT) ist ein Protein aus Bordetella sp. und ein mikrobielles Exotoxin. (de) In molecular biology, the cytotoxic necrotising factor family of proteins includes bacterial cytotoxic necrotising factor proteins and the related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) is a toxin whose structure from Escherichia coli revealed a 4-layer alpha/beta/beta/alpha structure containing mixed beta-sheets. CNF1 is expressed in strains of E. coli causing uropathogenic and neonatal meningitis. CNF1 alters host cell actin cytoskeleton and promotes bacterial invasion of the blood–brain barrier endothelial cells. CNF1 belongs to a unique group of large cytotoxins that cause constitutive activation of Rho guanosine triphosphatases (GTPases), which are key regulators of the actin cytoskeleton . (en) |
| rdfs:label |
Dermonekrotisches Toxin (de) Cytotoxic necrotising factor family (en) |
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wikipedia-en:Cytotoxic_necrotising_factor_family?oldid=1048013545&ns=0 |
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dbr:CNF |
| is dbo:wikiPageRedirects of |
dbr:Dermonecrotic_toxin |
| is dbo:wikiPageWikiLink of |
dbr:Millepora_tenera dbr:Brown_recluse_spider dbr:U._C._Chaturvedi dbr:CNF dbr:TM7x dbr:Dermonecrotic_toxin |
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