Cytotrienin A (original) (raw)
Cytotrienin A (Cyt A) is a secondary metabolite isolated from Streptomyces sp. RK95-74 isolated from soil in Japan in 1997. Cyt A is an ansamycin. Cytotrienin A induces apoptosis on HL-60 cells, as well as inhibiting translation in eukaryotes by inhibiting eukaryotic elongation factor 1A (eEF1A), which can act as an oncogene. These functions lead to the potential of the microbial metabolite acting as an anticancer agent, specifically for blood cancers, as it has proved to be more effective with leukemic cell lines. Cyt A is thought to induce apoptosis by activating c-Jun N-terminal Kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and p36 myelin basic protein (MBP) kinase.
| Property | Value |
|---|---|
| dbo:abstract | Cytotrienin A (Cyt A) is a secondary metabolite isolated from Streptomyces sp. RK95-74 isolated from soil in Japan in 1997. Cyt A is an ansamycin. Cytotrienin A induces apoptosis on HL-60 cells, as well as inhibiting translation in eukaryotes by inhibiting eukaryotic elongation factor 1A (eEF1A), which can act as an oncogene. These functions lead to the potential of the microbial metabolite acting as an anticancer agent, specifically for blood cancers, as it has proved to be more effective with leukemic cell lines. Cyt A is thought to induce apoptosis by activating c-Jun N-terminal Kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and p36 myelin basic protein (MBP) kinase. (en) |
| dbo:iupacName | [(5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(23),6,8,10,16,20(24),21-heptaen-13-yl] 1-(cyclohexene-1-carbonylamino)cyclopropane-1-carboxylate (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Cytotrienin-a.jpg?width=300 |
| dbo:wikiPageID | 54112127 (xsd:integer) |
| dbo:wikiPageLength | 6609 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1086960331 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Metabolite dbr:Ansamycin dbc:Cyclopropanes dbc:Lactams dbr:ICAM-1 dbr:Stereochemistry dbc:Streptomyces dbr:Lactam dbr:Apoptosis dbr:Streptomyces dbr:HL60 dbr:Eukaryotic_translation_elongation_factor_1_alpha_1 dbr:Angiogenesis dbc:Heterocyclic_compounds_with_2_rings dbr:Effective_dose_(pharmacology) dbr:HUVEC dbr:Myelin_basic_protein dbr:Reactive_oxygen_species dbr:Oncogene dbr:Caspase-3 dbr:MAPK dbr:JNK dbr:TNF-α |
| dbp:imagefile | Cytotrienin-a.jpg (en) |
| dbp:iupacname | [-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1,6,8,10,16,20,21-heptaen-13-yl] 1-cyclopropane-1-carboxylate (en) |
| dbp:name | Cytotrienin A (en) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Chembox_Structure dbt:Chembox_Thermochemistry |
| dcterms:subject | dbc:Cyclopropanes dbc:Lactams dbc:Streptomyces dbc:Heterocyclic_compounds_with_2_rings |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 dbo:ChemicalCompound |
| rdfs:comment | Cytotrienin A (Cyt A) is a secondary metabolite isolated from Streptomyces sp. RK95-74 isolated from soil in Japan in 1997. Cyt A is an ansamycin. Cytotrienin A induces apoptosis on HL-60 cells, as well as inhibiting translation in eukaryotes by inhibiting eukaryotic elongation factor 1A (eEF1A), which can act as an oncogene. These functions lead to the potential of the microbial metabolite acting as an anticancer agent, specifically for blood cancers, as it has proved to be more effective with leukemic cell lines. Cyt A is thought to induce apoptosis by activating c-Jun N-terminal Kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and p36 myelin basic protein (MBP) kinase. (en) |
| rdfs:label | Cytotrienin A (en) |
| owl:sameAs | wikidata:Cytotrienin A https://global.dbpedia.org/id/2qjzB |
| prov:wasDerivedFrom | wikipedia-en:Cytotrienin_A?oldid=1086960331&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Cytotrienin-a.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Cytotrienin_A |
| foaf:name | Cytotrienin A (en) |
| is dbo:wikiPageWikiLink of | dbr:Glossary_of_chemical_formulae |
| is foaf:primaryTopic of | wikipedia-en:Cytotrienin_A |
