DAHP synthase (original) (raw)
3-Desoxyarabinoheptulosanat-7-phosphat-Synthase (DAHP-Synthase) ist ein Enzym, das zum größten Teil in Bakterien, aber auch in Eukaryoten und Archaeen verkommt. Das Enzym zu den sogenannten DAHP-Synthasen, die die erste enzymatische Reaktion des Shikimisäurewegs katalysieren. Innerhalb der DAHP-Synthasen wird derzeit zwischen zwei Klassen unterschieden, wobei eine Klasse ausschließlich Enzyme von Pflanzen umfasst und die andere sich auf Enzyme von Mikroorganismen beschränkt, zu der auch die 3-Desoxyarabinoheptulosanat-7-phosphat-Synthase gehört.
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| dbo:abstract | 3-Desoxyarabinoheptulosanat-7-phosphat-Synthase (DAHP-Synthase) ist ein Enzym, das zum größten Teil in Bakterien, aber auch in Eukaryoten und Archaeen verkommt. Das Enzym zu den sogenannten DAHP-Synthasen, die die erste enzymatische Reaktion des Shikimisäurewegs katalysieren. Innerhalb der DAHP-Synthasen wird derzeit zwischen zwei Klassen unterschieden, wobei eine Klasse ausschließlich Enzyme von Pflanzen umfasst und die andere sich auf Enzyme von Mikroorganismen beschränkt, zu der auch die 3-Desoxyarabinoheptulosanat-7-phosphat-Synthase gehört. (de) 3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase (EC 2.5.1.54) is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan. Since it is the first enzyme in the shikimate pathway, it controls the amount of carbon entering the pathway. Enzyme inhibition is the primary method of regulating the amount of carbon entering the pathway. Forms of this enzyme differ between organisms, but can be considered DAHP synthase based upon the reaction that is catalyzed by this enzyme. In enzymology, a DAHP synthase (EC 2.5.1.54) is an enzyme that catalyzes the chemical reaction phosphoenolpyruvate + D-erythrose 4-phosphate + H2O 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate The three substrates of this enzyme are phosphoenolpyruvate, D-erythrose 4-phosphate, and H2O, whereas its two products are 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate and phosphate. (en) La 3-désoxy-7-phosphoheptulonate synthase, ou DAHP synthase, est une transférase qui catalyse la réaction : phosphoénolpyruvate + D-érythrose-4-phosphate + H2O 3-désoxy-D-arabinoheptulosonate-7-phosphate + phosphate. Cette enzyme intervient à la première étape de la voie du shikimate, qui permet à un grand nombre d'êtres vivants — mais pas aux animaux — de produire la plupart des acides aminés aromatiques. Elle contrôle par conséquent la quantité de carbone qui entre dans cette voie métabolique à travers d'une part la rétro-inhibition exercée par les acides aminés aromatiques, d'autre part le contrôle de l'expression du gène qui la code. Ces deux mécanismes sont à l'œuvre chez les bactéries, mais seul le second est effectif chez les plantes. Chez Escherichia coli, il existe trois isoenzymes de DAHP synthase, chacune étant sensible à l'un des trois acides aminés aromatiques produits par la voie du shikimate. On a par exemple montré que la DAHP synthase sensible à la tyrosine chez E. coli est inhibée par la tyrosine par inhibition incompétitive par rapport au phosphoénolpyruvate, mais par inhibition compétitive par rapport à l'érythrose-4-phosphate, lorsque la concentration de tyrosine dépasse 10 µmolL·-1. De plus, elle est inhibée par le phosphate de manière incompétitive par rapport aux deux substrats, et est inhibée par le 3-désoxy-D-arabinoheptulosonate-7-phosphate de manière compétitive par rapport au phosphoénolpyruvate et incompétitive par rapport à l'érythrose-4-posphate. (fr) La 3-deossi-7-fosfoeptulonato sintasi o DAHP sintasi è un enzima numero EC 2.5.1.54 appartenente alla classe delle transferasi, che catalizza la seguente reazione: fosfoenolpiruvato + D-eritrosio 4-fosfato + H2O 3-deossi-D-arabino-ept-2-ulosonato-7-fosfato + fosfato Si tratta della prima reazione della via dello shikimato. (it) |
| dbo:ecNumber | 2.5.1.54 |
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| dbp:caption | Structure of Aquifex aeolicus kdo8ps in complex with z-methyl-pep 2-dehydro-3-deoxyphosphooctonate aldolase. (en) |
| dbp:casNumber | 9026 (xsd:integer) |
| dbp:ecNumber | 2.500000 (xsd:double) |
| dbp:goCode | 3849 (xsd:integer) |
| dbp:interpro | IPR002480 (en) IPR006218 (en) |
| dbp:iubmbEcNumber | 2 (xsd:integer) |
| dbp:name | 3 (xsd:integer) Class-II DAHP synthetase family (en) DAHP synthetase I domain (en) |
| dbp:pfam | PF00793 (en) PF01474 (en) |
| dbp:pfamClan | CL0036 (en) |
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| dbp:symbol | DAHP_synth_1 (en) DAHP_synth_2 (en) |
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| rdfs:comment | 3-Desoxyarabinoheptulosanat-7-phosphat-Synthase (DAHP-Synthase) ist ein Enzym, das zum größten Teil in Bakterien, aber auch in Eukaryoten und Archaeen verkommt. Das Enzym zu den sogenannten DAHP-Synthasen, die die erste enzymatische Reaktion des Shikimisäurewegs katalysieren. Innerhalb der DAHP-Synthasen wird derzeit zwischen zwei Klassen unterschieden, wobei eine Klasse ausschließlich Enzyme von Pflanzen umfasst und die andere sich auf Enzyme von Mikroorganismen beschränkt, zu der auch die 3-Desoxyarabinoheptulosanat-7-phosphat-Synthase gehört. (de) La 3-deossi-7-fosfoeptulonato sintasi o DAHP sintasi è un enzima numero EC 2.5.1.54 appartenente alla classe delle transferasi, che catalizza la seguente reazione: fosfoenolpiruvato + D-eritrosio 4-fosfato + H2O 3-deossi-D-arabino-ept-2-ulosonato-7-fosfato + fosfato Si tratta della prima reazione della via dello shikimato. (it) 3-Deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase (EC 2.5.1.54) is the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine, tyrosine, and tryptophan. Since it is the first enzyme in the shikimate pathway, it controls the amount of carbon entering the pathway. Enzyme inhibition is the primary method of regulating the amount of carbon entering the pathway. Forms of this enzyme differ between organisms, but can be considered DAHP synthase based upon the reaction that is catalyzed by this enzyme. (en) La 3-désoxy-7-phosphoheptulonate synthase, ou DAHP synthase, est une transférase qui catalyse la réaction : phosphoénolpyruvate + D-érythrose-4-phosphate + H2O 3-désoxy-D-arabinoheptulosonate-7-phosphate + phosphate. (fr) |
| rdfs:label | 3-Desoxyarabinoheptulosanat-7-phosphat-Synthase (de) DAHP synthase (en) DAHP synthase (fr) 3-deossi-7-fosfoeptulonato sintasi (it) |
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| foaf:depiction | wiki-commons:Special:FilePath/DAHP_synthase_cartoon_quartenary_structure.png wiki-commons:Special:FilePath/DAHP_synthase_quarternary_structure.png wiki-commons:Special:FilePath/DAHP_synthase_reaction_2.png wiki-commons:Special:FilePath/PDB_1pck_EBI.jpg |
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| foaf:name | 3-deoxy-7-phosphoheptulonate synthase (en) |
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