| dbo:abstract |
DAMGO ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin) is a synthetic opioid peptide with high μ-opioid receptor specificity. It was synthesized as a biologically stable analog of δ-opioid receptor-preferring endogenous opioids, leu- and met-enkephalin. Structures of DAMGO bound to the µ opioid receptor reveal a very similar binding pose to morphinans. Its structure is H-Tyr-D-Ala-Gly-N-MePhe-Gly-ol. DAMGO has been used in experimental settings for the possibility of alleviating or reducing opiate tolerance for patients under the treatment of an opioid. Such treatment on rats, adding DAMGO to morphine administration, showed that after seven days morphine had as much of an effect at the same dosage as the first day when administered together with DAMGO to the rats, whereas a separate control group of rats that were administered the same dosage of morphine over the course of the same week, but without DAMGO, displayed an increased tolerance and lessened analgesic efficacy toward the end of that week. (en) |
| dbo:alternativeName |
Ala2-MePhe4-Glyol5-Enkephalin, DAGO, DAMGE (en) |
| dbo:iupacName |
(2S)-2-2-[[(2R)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]-methylamino]-N-(2-hydroxyethyl)-3-phenylpropanamide (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/DAMGO_Structure.svg?width=300 |
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| dbo:wikiPageLength |
4907 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
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| dbo:wikiPageWikiLink |
dbr:Enkephalin dbr:DPDPE dbc:Mu-opioid_receptor_agonists dbr:Morphiceptin dbr:Morphinan dbr:Opioid_peptide dbr:DADLE dbr:Delta_opioid_receptor dbc:Synthetic_opioids dbr:Μ-opioid_receptor dbc:Opioid_peptides dbr:Opioid dbr:Mu_opioid_receptor dbr:2-[[(2''R'')...-(2-hydroxyethyl)-3-phenylpropanamide |
| dbp:imagefile |
DAMGO Structure.svg (en) |
| dbp:iupacname |
-2 (xsd:integer) |
| dbp:othernames |
Ala2-MePhe4-Glyol5-Enkephalin, DAGO, DAMGE (en) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
403686009 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:wikiPageUsesTemplate |
dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Stdinchicite dbt:Opioid_receptor_modulators |
| dct:subject |
dbc:Mu-opioid_receptor_agonists dbc:Synthetic_opioids dbc:Opioid_peptides |
| gold:hypernym |
dbr:Peptide |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatMolecularFormulas yago:WikicatOpioidPeptides yago:Abstraction100002137 yago:Amide114724264 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:Peptide114743046 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound yago:Statement106722453 yago:Substance100019613 yago:WikicatPeptides umbel-rc:ChemicalSubstanceType |
| rdfs:comment |
DAMGO ([D-Ala2, N-MePhe4, Gly-ol]-enkephalin) is a synthetic opioid peptide with high μ-opioid receptor specificity. It was synthesized as a biologically stable analog of δ-opioid receptor-preferring endogenous opioids, leu- and met-enkephalin. Structures of DAMGO bound to the µ opioid receptor reveal a very similar binding pose to morphinans. Its structure is H-Tyr-D-Ala-Gly-N-MePhe-Gly-ol. (en) |
| rdfs:label |
DAMGO (en) |
| owl:sameAs |
freebase:DAMGO yago-res:DAMGO wikidata:DAMGO http://azb.dbpedia.org/resource/دیایامجیاو dbpedia-fa:DAMGO dbpedia-sh:DAMGO dbpedia-sr:DAMGO https://global.dbpedia.org/id/4j1Vr |
| prov:wasDerivedFrom |
wikipedia-en:DAMGO?oldid=1122120610&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/DAMGO_Structure.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:DAMGO |
| is dbo:wikiPageRedirects of |
dbr:C26H35N5O6 dbr:DAMGE |
| is dbo:wikiPageWikiLink of |
dbr:List_of_opioids dbr:DPDPE dbr:Dango_(disambiguation) dbr:C26H35N5O6 dbr:DAMGE dbr:DADLE dbr:Herkinorin dbr:Μ-opioid_receptor dbr:Ventrobasal_complex dbr:Opioid |
| is foaf:primaryTopic of |
wikipedia-en:DAMGO |
