DCPS (gene) (original) (raw)
Scavenger mRNA-decapping enzyme DcpS is a protein that in humans is encoded by the DCPS gene. The scavenger mRNA decapping enzymes include Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrates to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as a substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP). The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence in its C-terminal domain, with three histidines separated by hydrophobic re
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| dbo:abstract | Scavenger mRNA-decapping enzyme DcpS is a protein that in humans is encoded by the DCPS gene. The scavenger mRNA decapping enzymes include Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrates to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as a substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP). The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence in its C-terminal domain, with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. (en) DCPS (англ. Decapping enzyme, scavenger) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 337 амінокислот, а молекулярна маса — 38 609. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до гідролаз, фосфопротеїнів. Задіяний у таких біологічних процесах, як процесинг мРНК, сплайсинг мРНК, ацетилювання. Локалізований у цитоплазмі, ядрі. (uk) |
| dbo:thumbnail | wiki-commons:Special:FilePath/PDB_1vlr_EBI.jpg?width=300 |
| dbo:wikiPageExternalLink | https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q96C86 |
| dbo:wikiPageID | 14877613 (xsd:integer) |
| dbo:wikiPageLength | 10492 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1115927127 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Biology dbr:MRNA dbc:Protein_families dbr:Pyrophosphatase dbr:Gene dbr:Al-Raqad_syndrome dbr:Directionality_(molecular_biology) dbr:Protein_family dbr:Protein dbr:Residue_(chemistry) dbr:Histidine dbr:Hydrolyse dbr:Hydrophobic dbr:Sequence_motif dbr:Sequence_(biology) dbr:Exonuclease dbr:Exosome_complex dbr:Oligonucleotides dbr:Enzyme_substrate dbr:Protein_motif dbr:5'_cap dbr:Dinucleotide dbr:Histidines |
| dbp:caption | crystal structure of mrna decapping enzyme from mus musculus at 1.83 a resolution (en) |
| dbp:interpro | IPR008594 (en) |
| dbp:name | Scavenger mRNA decapping enzyme N-terminal (en) Scavenger mRNA decapping enzyme C-term binding (en) |
| dbp:pfam | PF05652 (en) PF11969 (en) |
| dbp:pfamClan | CL0265 (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:symbol | DcpS (en) DcpS_C (en) |
| dbp:wikiPageUsesTemplate | dbt:Gene-11-stub dbt:Cite_journal dbt:Infobox_gene dbt:Infobox_protein_family dbt:InterPro_content dbt:PDB_Gallery dbt:Refbegin dbt:Refend dbt:Reflist |
| dct:subject | dbc:Protein_families |
| gold:hypernym | dbr:Protein |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:HumanGene dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 yago:WikicatProteinFamilies |
| rdfs:comment | Scavenger mRNA-decapping enzyme DcpS is a protein that in humans is encoded by the DCPS gene. The scavenger mRNA decapping enzymes include Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrates to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as a substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP). The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence in its C-terminal domain, with three histidines separated by hydrophobic re (en) DCPS (англ. Decapping enzyme, scavenger) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 337 амінокислот, а молекулярна маса — 38 609. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | DCPS (gene) (en) DCPS (uk) |
| owl:sameAs | freebase:DCPS (gene) yago-res:DCPS (gene) wikidata:DCPS (gene) dbpedia-fa:DCPS (gene) http://tt.dbpedia.org/resource/DCPS dbpedia-uk:DCPS (gene) https://global.dbpedia.org/id/kPiy |
| prov:wasDerivedFrom | wikipedia-en:DCPS_(gene)?oldid=1115927127&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/PDB_1vlr_EBI.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:DCPS_(gene) |
| is dbo:wikiPageDisambiguates of | dbr:DCPS |
| is dbo:wikiPageWikiLink of | dbr:List_of_human_protein-coding_genes_1 dbr:Bruno_Reversade dbr:DCPS dbr:Al-Raqad_syndrome |
| is foaf:primaryTopic of | wikipedia-en:DCPS_(gene) |
