Delorazepam (original) (raw)
Delorazepam, also known as chlordesmethyldiazepam and nordiclazepam, is a drug which is a benzodiazepine and a derivative of desmethyldiazepam. It is marketed in Italy, where it is available under the trade name EN and Dadumir. Delorazepam (chlordesmethyldiazepam) is also an active metabolite of the benzodiazepine drugs diclazepam and cloxazolam. Adverse effects may include hangover type effects, drowsiness, behavioural impairments and short-term memory impairments. Similar to other benzodiazepines delorazepam has anxiolytic, skeletal muscle relaxant, hypnotic and anticonvulsant properties.
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| dbo:abstract | Delorazepam, also known as chlordesmethyldiazepam and nordiclazepam, is a drug which is a benzodiazepine and a derivative of desmethyldiazepam. It is marketed in Italy, where it is available under the trade name EN and Dadumir. Delorazepam (chlordesmethyldiazepam) is also an active metabolite of the benzodiazepine drugs diclazepam and cloxazolam. Adverse effects may include hangover type effects, drowsiness, behavioural impairments and short-term memory impairments. Similar to other benzodiazepines delorazepam has anxiolytic, skeletal muscle relaxant, hypnotic and anticonvulsant properties. (en) Delorazepam ist eine chemische Verbindung aus der Gruppe der Benzodiazepine mit beruhigender und angstlösender Wirkung. Chemisch handelt es sich um ein am C-2' chloriertes Derivat des Nordazepams. Natürlich kommt Delorazepam in geringen Mengen (100–200 ng/g) im Estragon (Artemisia dracunculus) vor. (de) Le délorazépam, également connu sous le nom chlordesméthyldiazépam, est un médicament anxiolytique de la famille des benzodiazépines et un métabolite actif du diclazépam appelé également . Il a beaucoup de ressemblance avec le lorazépam sauf qu'à sa différence, il n'a pas de groupement hydroxy (-OH) en position 3 du cycle diazépine, ce qui se traduit par un effet similaire au lorazépam, c'est-à-dire fortement anxiolytique avec des effets amnésiants prononcés mais du fait de l’absence du groupement hydroxy il a une demi-vie plus longue, c'est-à-dire qu'il agit plus longtemps. Il est commercialisé en Italie sous le nom de Dadumir. (fr) Il Delorazepam, venduto con il nome commerciale di EN, è una benzodiazepina. (it) Delorazepam, (klordesmetyldiazepam), summaformel C15H10Cl2N2O, är ett ångestdämpande och lugnande preparat som tillhör gruppen bensodiazepiner. Substansen är narkotikaklassad och ingår i förteckning P IV i 1971 års psykotropkonvention, samt i förteckning IV i Sverige. (sv) Delorazepam – organiczny związek chemiczny, lek z grupy benzodiazepin. Jest objęty Konwencją o substancjach psychotropowych z 1971 roku (wykaz IV). W Polsce jest w grupie IV-P Ustawy o przeciwdziałaniu narkomanii. (pl) Delorazepam, também conhecido como clordesmetildiazepam e nordiclazepam, é um medicamento da classe dos benzodiazepínicos e um derivado do desmetildiazepam. É comercializado na Itália, onde está disponível sob os nomes comerciais EN e Dadumir Delorazepam (clordesmetildiazepam) também é um metabólito ativo dos medicamentos benzodiazepínicos diclazepam e cloxazolam. Os efeitos adversos podem incluir efeitos do tipo ressaca, sonolência, mudanças comportamentais e comprometimentos de memória de curto prazo. De modo similar a outros benzodiazepínicos, o delorazepam tem propriedades ansiolíticas, relaxantes musculo-esqueléticas, hipnóticas e anticonvulsivantes. (pt) |
| dbo:alternativeName | EN, Dadumir (en) |
| dbo:bioavailability | 87.000000 (xsd:float) |
| dbo:casNumber | 2894-67-9 |
| dbo:chEMBL | 268254 |
| dbo:drugbank | DB01511 |
| dbo:fdaUniiCode | O91W32476G |
| dbo:kegg | D07784 |
| dbo:pubchem | 17925 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Delorazepam_200.svg?width=300 |
| dbo:wikiPageID | 12348964 (xsd:integer) |
| dbo:wikiPageLength | 17459 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1121932675 (xsd:integer) |
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| dbp:alt | Ball-and-stick model of the delorazepam molecule (en) |
| dbp:atcPrefix | none (en) |
| dbp:bioavailability | 87.0 (dbd:perCent) |
| dbp:c | 15 (xsd:integer) |
| dbp:casNumber | 2894 (xsd:integer) |
| dbp:chembl | 268254 (xsd:integer) |
| dbp:chemspiderid | 16929 (xsd:integer) |
| dbp:cl | 2 (xsd:integer) |
| dbp:drugbank | DB01511 (en) |
| dbp:eliminationHalfLife | -504000.0 (dbd:second) |
| dbp:excretion | Renal (en) |
| dbp:h | 10 (xsd:integer) |
| dbp:image | Delorazepam molecule ball.png (en) |
| dbp:iupacName | 7 (xsd:integer) |
| dbp:kegg | D07784 (en) |
| dbp:legalCa | Schedule IV (en) |
| dbp:legalDe | Anlage III (en) |
| dbp:legalUk | Class C (en) |
| dbp:legalUs | Schedule IV (en) |
| dbp:metabolism | dbr:Liver |
| dbp:n | 2 (xsd:integer) |
| dbp:o | 1 (xsd:integer) |
| dbp:pubchem | 17925 (xsd:integer) |
| dbp:routesOfAdministration | Oral (en) |
| dbp:smiles | ClC1=CC=CC=C1C2=NCC=O (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | CHIFCDOIPRCHCF-UHFFFAOYSA-N (en) |
| dbp:tradename | EN, Dadumir (en) |
| dbp:unii | O91W32476G (en) |
| dbp:verifiedrevid | 443682439 (xsd:integer) |
| dbp:watchedfields | changed (en) |
| dbp:width | 190 (xsd:integer) |
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| dct:subject | dbc:Chloroarenes dbc:GABAA_receptor_positive_allosteric_modulators dbc:Hypnotics dbc:Lactams dbc:Benzodiazepines |
| gold:hypernym | dbr:Drug |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatBenzodiazepines yago:Agent114778436 yago:Benzodiazepine102830852 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Hypnagogue114913744 yago:Matter100020827 yago:Medicine103740161 yago:MinorTranquilizer103771443 yago:MuscleRelaxant103800001 yago:PhysicalEntity100001930 yago:PsychotropicAgent104017429 yago:Relaxant104072811 yago:WikicatHypnotics dbo:Drug yago:Sedative-hypnotic104166841 yago:Sedative104166553 yago:Soporific104260934 yago:Substance100020090 yago:Tranquilizer104470232 umbel-rc:DrugProduct |
| rdfs:comment | Delorazepam, also known as chlordesmethyldiazepam and nordiclazepam, is a drug which is a benzodiazepine and a derivative of desmethyldiazepam. It is marketed in Italy, where it is available under the trade name EN and Dadumir. Delorazepam (chlordesmethyldiazepam) is also an active metabolite of the benzodiazepine drugs diclazepam and cloxazolam. Adverse effects may include hangover type effects, drowsiness, behavioural impairments and short-term memory impairments. Similar to other benzodiazepines delorazepam has anxiolytic, skeletal muscle relaxant, hypnotic and anticonvulsant properties. (en) Delorazepam ist eine chemische Verbindung aus der Gruppe der Benzodiazepine mit beruhigender und angstlösender Wirkung. Chemisch handelt es sich um ein am C-2' chloriertes Derivat des Nordazepams. Natürlich kommt Delorazepam in geringen Mengen (100–200 ng/g) im Estragon (Artemisia dracunculus) vor. (de) Il Delorazepam, venduto con il nome commerciale di EN, è una benzodiazepina. (it) Delorazepam, (klordesmetyldiazepam), summaformel C15H10Cl2N2O, är ett ångestdämpande och lugnande preparat som tillhör gruppen bensodiazepiner. Substansen är narkotikaklassad och ingår i förteckning P IV i 1971 års psykotropkonvention, samt i förteckning IV i Sverige. (sv) Delorazepam – organiczny związek chemiczny, lek z grupy benzodiazepin. Jest objęty Konwencją o substancjach psychotropowych z 1971 roku (wykaz IV). W Polsce jest w grupie IV-P Ustawy o przeciwdziałaniu narkomanii. (pl) Delorazepam, também conhecido como clordesmetildiazepam e nordiclazepam, é um medicamento da classe dos benzodiazepínicos e um derivado do desmetildiazepam. É comercializado na Itália, onde está disponível sob os nomes comerciais EN e Dadumir Delorazepam (clordesmetildiazepam) também é um metabólito ativo dos medicamentos benzodiazepínicos diclazepam e cloxazolam. Os efeitos adversos podem incluir efeitos do tipo ressaca, sonolência, mudanças comportamentais e comprometimentos de memória de curto prazo. De modo similar a outros benzodiazepínicos, o delorazepam tem propriedades ansiolíticas, relaxantes musculo-esqueléticas, hipnóticas e anticonvulsivantes. (pt) Le délorazépam, également connu sous le nom chlordesméthyldiazépam, est un médicament anxiolytique de la famille des benzodiazépines et un métabolite actif du diclazépam appelé également . Il a beaucoup de ressemblance avec le lorazépam sauf qu'à sa différence, il n'a pas de groupement hydroxy (-OH) en position 3 du cycle diazépine, ce qui se traduit par un effet similaire au lorazépam, c'est-à-dire fortement anxiolytique avec des effets amnésiants prononcés mais du fait de l’absence du groupement hydroxy il a une demi-vie plus longue, c'est-à-dire qu'il agit plus longtemps. (fr) |
| rdfs:label | Delorazepam (de) Delorazepam (en) Delorazepam (it) Délorazépam (fr) Delorazepam (pl) Delorazepam (pt) Delorazepam (sv) |
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| prov:wasDerivedFrom | wikipedia-en:Delorazepam?oldid=1121932675&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Delorazepam_200.svg wiki-commons:Special:FilePath/Delorazepam_molecule_ball.png |
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| is dbo:wikiPageWikiLink of | dbr:List_of_benzodiazepines dbr:List_of_compounds_with_carbon_number_15 dbr:Nordiclazepam dbr:Controlled_Drugs_and_Substances_Act dbr:Convention_on_Psychotropic_Substances dbr:Opium_Law dbr:C15H10Cl2N2O dbr:Drug_policy_of_India dbr:Drugs_controlled_by_the_German_Betäubungsmittelgesetz dbr:Drugs_controlled_by_the_UK_Misuse_of_Drugs_Act dbr:List_of_Schedule_IV_drugs_(US) dbr:Misuse_of_Drugs_Act_1977 dbr:Diclazepam dbr:Phenazepam dbr:Mexazolam dbr:Reclazepam dbr:List_of_drugs:_De dbr:Chlordesmethyldiazepam |
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