Mexazolam (original) (raw)
Mexazolam (marketed under the trade names Melex and Sedoxil) is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam, but not the HMG-CoA reductase inhibitor pravastatin. Its principal active metabolites are chlordesmethyldiazepam (also known as chloronordiazepam or delorazepam, trade name Dadumir) and chloroxazepam (also known as lorazepam, trade name Ativan).
| Property | Value |
|---|---|
| dbo:abstract | Mexazolam (marketed under the trade names Melex and Sedoxil) is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam, but not the HMG-CoA reductase inhibitor pravastatin. Its principal active metabolites are chlordesmethyldiazepam (also known as chloronordiazepam or delorazepam, trade name Dadumir) and chloroxazepam (also known as lorazepam, trade name Ativan). (en) Il mexazolam (commercializzato con i nomi commerciali Melex e Sedoxil) è uno psicofarmaco derivato delle benzodiazepine. Il mexazolam è stato testato per l'ansia ed è risultato efficace nell'alleviarla a una settimana di follow-up, tuttavia, dopo tre settimane di terapia, il mexazolam aveva perso le sue proprietà ansiolitiche terapeutiche diventando non più efficace per via dell’effetto placebo, presumibilmente a causa della tolleranza alle benzodiazepine. Mexazolam è metabolizzato attraverso la via del CYP3A4. Gli inibitori della HMG-CoA reduttasi inclusi simvastatina, simvastatina acida, lovastatina, fluvastatina, atorvastatina e cerivastatina inibiscono il metabolismo del mexazolam, ma non l'inibitore della HMG-CoA reduttasi pravastatina. I suoi principali metaboliti attivi sono chlordesmetildiazepam (noto anche come chloronordiazepam o delorazepam) e cloroxazepam (noto anche come lorazepam). (it) メキサゾラム (mexazolam) はベンゾジアゼピン系の抗不安薬の一種。長時間作用型。神経症や心身症からくる症状に適応がある。日本での商品名はメレックス。 連用により依存症、急激な量の減少により離脱症状を生じることがある。 (ja) Mexazolam (comercializado sob os nomes comerciais Sedoxil e Melex) é uma substância utilizada como medicamento pertencente ao grupo das benzodiazepinas. (pt) |
| dbo:alternativeName | Melex, Sedoxil (en) |
| dbo:casNumber | 31868-18-5 |
| dbo:fdaUniiCode | S5969B6237 |
| dbo:kegg | D01316 |
| dbo:pubchem | 4177 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Mexazolam.svg?width=300 |
| dbo:wikiPageID | 9692425 (xsd:integer) |
| dbo:wikiPageLength | 5035 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1082380008 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Pravastatin dbr:Benzodiazepine dbr:Delorazepam dbc:Chloroarenes dbc:GABAA_receptor_positive_allosteric_modulators dbc:Lactams dbr:Liver dbr:Lorazepam dbr:Lovastatin dbr:Simvastatin dbc:Oxazolobenzodiazepines dbr:Cerivastatin dbr:Fluvastatin dbr:Atorvastatin dbr:Kidney dbr:CYP3A4 dbr:HMG-CoA_reductase_inhibitors dbr:Simvastatin_acid |
| dbp:atcPrefix | N05 (en) |
| dbp:atcSuffix | BA25 (en) |
| dbp:c | 18 (xsd:integer) |
| dbp:casNumber | 31868 (xsd:integer) |
| dbp:chemspiderid | 4033 (xsd:integer) |
| dbp:cl | 2 (xsd:integer) |
| dbp:excretion | dbr:Kidney |
| dbp:h | 16 (xsd:integer) |
| dbp:image | Mexazolam3d.png (en) |
| dbp:iupacName | 10 (xsd:integer) |
| dbp:kegg | D01316 (en) |
| dbp:legalCa | Schedule IV (en) |
| dbp:metabolism | Liver (en) |
| dbp:n | 2 (xsd:integer) |
| dbp:o | 2 (xsd:integer) |
| dbp:pubchem | 4177 (xsd:integer) |
| dbp:routesOfAdministration | Oral (en) |
| dbp:smiles | Clc1ccccc1C42OCCC (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | ANUCDXCTICZJRH-UHFFFAOYSA-N (en) |
| dbp:synonyms | (13-chloro- 2-- 5-methyl- 3-oxa- 6,9-diazatricyclo[8.4.0.02,6] tetradeca- 1,11,13-trien- 8-one) (en) |
| dbp:tradename | Melex, Sedoxil (en) |
| dbp:unii | S5969B6237 (en) |
| dbp:verifiedrevid | 451165363 (xsd:integer) |
| dbp:width | 155 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:GABAAR_PAMs dbt:Reflist dbt:Short_description dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Drugs.com dbt:Benzodiazepines dbt:Sedative-stub |
| dcterms:subject | dbc:Chloroarenes dbc:GABAA_receptor_positive_allosteric_modulators dbc:Lactams dbc:Oxazolobenzodiazepines |
| gold:hypernym | dbr:Drug |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatBenzodiazepines yago:Agent114778436 yago:Benzodiazepine102830852 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Matter100020827 yago:Medicine103740161 yago:MinorTranquilizer103771443 yago:MuscleRelaxant103800001 yago:PhysicalEntity100001930 yago:PsychotropicAgent104017429 yago:Relaxant104072811 dbo:Drug yago:Sedative-hypnotic104166841 yago:Sedative104166553 yago:Substance100020090 yago:Tranquilizer104470232 umbel-rc:DrugProduct |
| rdfs:comment | Mexazolam (marketed under the trade names Melex and Sedoxil) is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam, but not the HMG-CoA reductase inhibitor pravastatin. Its principal active metabolites are chlordesmethyldiazepam (also known as chloronordiazepam or delorazepam, trade name Dadumir) and chloroxazepam (also known as lorazepam, trade name Ativan). (en) メキサゾラム (mexazolam) はベンゾジアゼピン系の抗不安薬の一種。長時間作用型。神経症や心身症からくる症状に適応がある。日本での商品名はメレックス。 連用により依存症、急激な量の減少により離脱症状を生じることがある。 (ja) Mexazolam (comercializado sob os nomes comerciais Sedoxil e Melex) é uma substância utilizada como medicamento pertencente ao grupo das benzodiazepinas. (pt) Il mexazolam (commercializzato con i nomi commerciali Melex e Sedoxil) è uno psicofarmaco derivato delle benzodiazepine. Il mexazolam è stato testato per l'ansia ed è risultato efficace nell'alleviarla a una settimana di follow-up, tuttavia, dopo tre settimane di terapia, il mexazolam aveva perso le sue proprietà ansiolitiche terapeutiche diventando non più efficace per via dell’effetto placebo, presumibilmente a causa della tolleranza alle benzodiazepine. Mexazolam è metabolizzato attraverso la via del CYP3A4. Gli inibitori della HMG-CoA reduttasi inclusi simvastatina, simvastatina acida, lovastatina, fluvastatina, atorvastatina e cerivastatina inibiscono il metabolismo del mexazolam, ma non l'inibitore della HMG-CoA reduttasi pravastatina. I suoi principali metaboliti attivi sono chlorde (it) |
| rdfs:label | Mexazolam (it) メキサゾラム (ja) Mexazolam (en) Mexazolam (pt) |
| owl:sameAs | freebase:Mexazolam yago-res:Mexazolam wikidata:Mexazolam dbpedia-it:Mexazolam dbpedia-ja:Mexazolam dbpedia-pt:Mexazolam dbpedia-sh:Mexazolam dbpedia-sr:Mexazolam https://global.dbpedia.org/id/4ntps |
| prov:wasDerivedFrom | wikipedia-en:Mexazolam?oldid=1082380008&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Mexazolam.svg wiki-commons:Special:FilePath/Mexazolam3d.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Mexazolam |
| is dbo:wikiPageRedirects of | dbr:Sedoxil |
| is dbo:wikiPageWikiLink of | dbr:List_of_benzodiazepines dbr:Rilmazolam dbr:ATC_code_N05 dbr:List_of_drugs:_Meu–Mi dbr:Sedoxil |
| is foaf:primaryTopic of | wikipedia-en:Mexazolam |
