| dbo:abstract |
Demegestone, sold under the brand name Lutionex, is a progestin medication which was previously used to treat luteal insufficiency but is now no longer marketed. It is taken by mouth. Demegestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has no androgenic activity. Demegestone was first described in 1966 and was introduced for medical use in France in 1974. It has only been marketed in France, and has since been discontinued in this country. (en) Il demegestone è un progestinico di sintesi, derivato dal 17-metilprogesterone. Presenta azioni simili a quelle del progesterone. Dopo somministrazione orale si osserva un picco di concentrazione plasmatica entro 2-3 ore. Il farmaco subisce trasformazione metabolica nel fegato, principalmente per idrossilazione in posizione 1, 2, 11 e 21; i suoi metaboliti sono stati isolati nella bile. È utilizzato per il trattamento di stati di insufficienza di progesterone, dismenorrea, irregolarità mestruali, sindrome premestruale, emorragie funzionali, menorragie dei fibromi uterini, endometriosi. Associato ad un estrogeno può essere impiegato come anticoncezionale. La dose abituale è di 0,5–2 mg al giorno dal 16º al 25º giorno del ciclo mestruale. Può causare alterazioni del ciclo mestruale, amenorrea, perdite ematiche uterine, seborrea, aggravamento dell'insufficienza venosa agli arti inferiori, disturbi gastrointestinali, ittero colestatico e prurito. Si sconsiglia l'uso in caso di insufficienza epatica e durante i primi tre mesi di gravidanza, nonché nei pazienti con anamnesi di tromboflebite o con manifestazioni in atto a carico del circolo venoso, soprattutto degli arti inferiori. (it) |
| dbo:alternativeName |
Lutionex (en) |
| dbo:casNumber |
10116-22-0 |
| dbo:chEBI |
135339 |
| dbo:chEMBL |
2104231 |
| dbo:class |
dbr:Progestin dbr:Progestogen_(medication) |
| dbo:fdaUniiCode |
6E89AM91SZ |
| dbo:kegg |
D07223 |
| dbo:pubchem |
93057 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Demegestone.svg?width=300 |
| dbo:wikiPageID |
26781366 (xsd:integer) |
| dbo:wikiPageLength |
14455 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1103044509 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Potency_(pharmacology) dbr:Progesterone dbr:Progesterone_(medication) dbr:Progestin dbr:Progestogen_(medication) dbr:Promegestone dbr:Roussel_Uclaf dbr:Metabolite dbr:Norpregnane dbr:19-norprogesterone dbr:Dehydration dbr:Androgen dbr:Antiglucocorticoid dbr:Hydrocortisone dbr:Ligand_(biochemistry) dbr:Intravenous_injection dbc:Abandoned_drugs dbc:Conjugated_dienes dbc:Diketones dbc:Enones dbc:Progestogens dbr:Estrogen_(medication) dbr:Oral_administration dbr:Oral_contraceptive dbc:Norpregnanes dbr:Antiandrogen dbr:Aromatization dbr:Steroid dbr:Deoxycorticosterone dbr:Pharmacodynamics dbr:Progesterone_receptor dbc:Antiandrogens dbr:Trimegestone dbr:Mineralocorticoid dbr:Ovulation dbr:Agonist dbr:Aldosterone dbr:Estradiol_(medication) dbr:France dbr:Glucocorticoid dbr:Glucocorticoid_receptor dbr:Generic_term dbr:Testosterone_(medication) dbr:Hydroxylation dbr:Affinity_(pharmacology) dbr:Bioassay dbr:Bioavailability dbr:Biological_half-life dbr:Biological_target dbr:Endometrial_transformation dbr:Metabolic_clearance_rate dbr:Infertility dbr:Metabolism dbr:Hydroxyl dbr:Urine dbr:Volume_of_distribution dbr:Excretion dbr:Moxestrol dbr:Synthetic_compound dbr:Clauberg_test dbr:Hydroxyl_group dbr:17α-methyl-19-norprogesterone dbr:17α-methylprogesterone dbr:Chemical_derivative dbr:Luteal_insufficiency |
| dbp:alt |
Ball-and-stick model of the demegestone molecule (en) Skeletal formula of demegestone (en) |
| dbp:atcPrefix |
G03 (en) |
| dbp:atcSuffix |
DB05 (en) |
| dbp:bioavailability |
Good (en) |
| dbp:c |
21 (xsd:integer) |
| dbp:casNumber |
10116 (xsd:integer) |
| dbp:chebi |
135339 (xsd:integer) |
| dbp:chembl |
2104231 (xsd:integer) |
| dbp:chemspiderid |
84009 (xsd:integer) |
| dbp:class |
dbr:Progestin dbr:Progestogen_(medication) |
| dbp:excretion |
dbr:Urine |
| dbp:h |
28 (xsd:integer) |
| dbp:image |
Demegestone 3D ball.png (en) |
| dbp:iupacName |
-17 (xsd:integer) |
| dbp:kegg |
D07223 (en) |
| dbp:metabolism |
Hydroxylation, others (en) |
| dbp:metabolites |
• Others (en) • 21-Hydroxydemegestone (en) |
| dbp:o |
2 (xsd:integer) |
| dbp:pubchem |
93057 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Oral_administration |
| dbp:smiles |
CC[C@]1C (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
JWAHBTQSSMYISL-MHTWAQMVSA-N (en) |
| dbp:synonyms |
Dimegestone; R-2453; RU-2453; 17α-Methyl-δ9-19-norprogesterone; 17α-Methyl-19-norpregna-4,9-diene-3,20-dione (en) |
| dbp:title |
dbr:Pharmacodynamics |
| dbp:titlestyle |
background:#ccccff (en) |
| dbp:tradename |
Lutionex (en) |
| dbp:unii |
9223372036854775807 (xsd:decimal) |
| dbp:width |
215 (xsd:integer) 225 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Abbr dbt:Androgen_receptor_modulators dbt:Drugbox dbt:Glucocorticoid_receptor_modulators dbt:Navboxes dbt:Progesterone_receptor_modulators dbt:Reflist dbt:See_also dbt:Abbrlink dbt:Fdacite dbt:Progestogens_and_antiprogestogens |
| dct:subject |
dbc:Abandoned_drugs dbc:Conjugated_dienes dbc:Diketones dbc:Enones dbc:Progestogens dbc:Norpregnanes dbc:Antiandrogens |
| gold:hypernym |
dbr:Derivative |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatSteroids yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Steroid115057744 yago:Substance100019613 |
| rdfs:comment |
Demegestone, sold under the brand name Lutionex, is a progestin medication which was previously used to treat luteal insufficiency but is now no longer marketed. It is taken by mouth. Demegestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has no androgenic activity. Demegestone was first described in 1966 and was introduced for medical use in France in 1974. It has only been marketed in France, and has since been discontinued in this country. (en) Il demegestone è un progestinico di sintesi, derivato dal 17-metilprogesterone. Presenta azioni simili a quelle del progesterone. Dopo somministrazione orale si osserva un picco di concentrazione plasmatica entro 2-3 ore. Il farmaco subisce trasformazione metabolica nel fegato, principalmente per idrossilazione in posizione 1, 2, 11 e 21; i suoi metaboliti sono stati isolati nella bile. La dose abituale è di 0,5–2 mg al giorno dal 16º al 25º giorno del ciclo mestruale. (it) |
| rdfs:label |
Demegestone (en) Demegestone (it) |
| rdfs:seeAlso |
dbr:Progestin dbr:List_of_progestogens |
| owl:sameAs |
freebase:Demegestone wikidata:Demegestone http://azb.dbpedia.org/resource/دمجستون dbpedia-fa:Demegestone dbpedia-it:Demegestone dbpedia-sh:Demegestone dbpedia-sr:Demegestone dbpedia-vi:Demegestone https://global.dbpedia.org/id/4it8C yago-res:Demegestone |
| prov:wasDerivedFrom |
wikipedia-en:Demegestone?oldid=1103044509&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Demegestone.svg wiki-commons:Special:FilePath/Demegestone_3D_ball.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Demegestone |
| is dbo:wikiPageRedirects of |
dbr:ATC_code_G03DB05 dbr:ATCvet_code_QG03DB05 dbr:Lutionex dbr:R-2353 dbr:R-2453 dbr:R2353 dbr:R2453 dbr:RU-2353 dbr:RU-2453 dbr:RU2353 dbr:RU2453 dbr:RU_2353 dbr:RU_2453 dbr:R_2353 dbr:R_2453 dbr:Dimegestone |
| is dbo:wikiPageWikiLink of |
dbr:Progestogen_(medication) dbr:Promegestone dbr:C21H28O2 dbr:List_of_progestogens dbr:List_of_progestogens_available_in_the_United_States dbr:19-Norpregnane dbr:19-Norprogesterone dbr:17α-Methylprogesterone dbr:17α-Methyl-19-norprogesterone dbr:Gestonorone_caproate dbr:Trimegestone dbr:ATC_code_G03DB05 dbr:ATCvet_code_QG03DB05 dbr:ATC_code_G03 dbr:Segesterone_acetate dbr:Gestadienol_acetate dbr:Lutionex dbr:List_of_drugs:_De dbr:R-2353 dbr:R-2453 dbr:R2353 dbr:R2453 dbr:RU-2353 dbr:RU-2453 dbr:RU2353 dbr:RU2453 dbr:RU_2353 dbr:RU_2453 dbr:R_2353 dbr:R_2453 dbr:Dimegestone |
| is foaf:primaryTopic of |
wikipedia-en:Demegestone |
