| dbo:abstract |
Trimegestone, sold under the brand names Ondeva and Totelle among others, is a progestin medication which is used in menopausal hormone therapy and in the prevention of postmenopausal osteoporosis. It was also under development for use in birth control pills to prevent pregnancy, but ultimately was not marketed for this purpose. The medication is available alone or in combination with an estrogen. It is taken by mouth. Side effects of trimegestone include headache, breast tenderness, nervousness, abdominal pain, bloating, muscle cramps, nausea, depression, and vaginal bleeding among others. Trimegestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak antiandrogenic and antimineralocorticoid activity and no other important hormonal activity. Trimegestone was first described in 1979 and was introduced for medical use in 2001. It is sometimes described as a "fourth-generation" progestin. The medication is marketed throughout Europe and Latin America. It is not available in the United States or Canada. (en) |
| dbo:alternativeName |
Ginotex, Lovelle, Minique, Ondeva, Totelle, others (en) |
| dbo:bioavailability |
100.000000 (xsd:float) |
| dbo:casNumber |
74513-62-5 |
| dbo:chEBI |
136027 |
| dbo:chEMBL |
2104765 |
| dbo:class |
dbr:Progestin dbr:Progestogen_(medication) |
| dbo:drugbank |
DB13129 |
| dbo:fdaUniiCode |
4658K0H08W |
| dbo:kegg |
D06235 |
| dbo:pubchem |
68926 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Trimegestone.svg?width=300 |
| dbo:wikiPageExternalLink |
https://adisinsight.springer.com/drugs/800006479 https://adisinsight.springer.com/drugs/800006485 |
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| dbo:wikiPageWikiLink |
dbr:Canada dbr:Potency_(pharmacology) dbr:Pregnancy dbr:Progesterone dbr:Progesterone_(medication) dbr:Progestin dbr:Progestogen_(medication) dbr:Promegestone dbr:Endometrium dbr:Metabolite dbr:Norpregnane dbr:19-norprogesterone dbr:Belgium dbr:Bloating dbr:Brazil dbr:Demegestone dbr:Denmark dbr:Androgen dbr:Androgen_receptor dbr:Antiestrogen dbr:Antiglucocorticoid dbr:Antimineralocorticoid dbr:Lithuania dbr:United_Kingdom dbr:United_States dbr:Venezuela dbr:Depression_(mood) dbr:Menopause dbc:Antimineralocorticoids dbc:Dienes dbc:Diketones dbc:Human_drug_metabolites dbc:Progestogens dbc:Secondary_alcohols dbr:Conjugated_estrogens dbr:Estrogen_(medication) dbr:Nausea dbr:Oral_administration dbr:Vaginal_bleeding dbr:Elimination_half-life dbr:Endometriosis dbr:English-speaking_countries dbr:Gestodene dbc:Norpregnanes dbr:Antiandrogen dbr:Anxiety dbr:Steroid dbr:Hot_flash dbr:Birth_control_pill dbr:Pharmacodynamics dbr:Progesterone_receptor dbr:Transdermal_patch dbr:Symptom dbr:Australia dbr:Austria dbc:Antiandrogens dbr:Active_metabolite dbr:GABAA_receptor dbr:Mineralocorticoid dbr:Ovulation dbr:Agonist dbr:Aldosterone dbr:Cyproterone_acetate dbr:Estradiol_(medication) dbr:Estrogen_receptor dbr:Ethinylestradiol dbr:Europe dbr:Finland dbr:France dbr:Norway dbr:Osteoporosis dbr:Glucocorticoid dbr:Glucocorticoid_receptor dbr:Generic_term dbr:Headache dbr:Ireland dbr:Italy dbr:Testosterone_(medication) dbr:Hydroxylation dbr:Metrorrhagia dbr:Argentina dbr:Abdominal_pain dbr:Chile dbr:Affinity_(pharmacology) dbr:Latin_America dbr:Binding_selectivity dbr:Bioavailability dbr:Biological_target dbr:Sweden dbr:Cmax_(pharmacology) dbr:Tissue_(biology) dbr:Dexamethasone dbr:South_Africa dbr:Human_serum_albumin dbr:Endometrial_transformation dbr:Menopausal_syndrome dbr:Metabolism dbr:Mexico dbr:New_Zealand dbr:Sedative dbr:Wyeth dbr:Menopausal_hormone_therapy dbr:Mineralocorticoid_receptor dbr:Side_effect dbr:Neurosteroid dbr:Steroid_hormone_receptor dbr:Plasma_protein_binding dbr:Steady-state_levels dbr:Sanofi-Aventis dbr:19-nortestosterone dbr:Synthetic_compound dbr:Hydroxyl_group dbr:Breast_tenderness dbr:17α-methyl-19-norprogesterone dbr:17α-methylprogesterone dbr:Chemical_derivative dbr:Muscle_cramp dbr:Vaginal_atrophy dbr:Antigonadotropic dbr:Hormonal_agent |
| dbp:atcPrefix |
G03 (en) |
| dbp:atcSuffix |
FA16 (en) |
| dbp:bioavailability |
100.0 |
| dbp:c |
22 (xsd:integer) |
| dbp:casNumber |
74513 (xsd:integer) |
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136027 (xsd:integer) |
| dbp:chembl |
2104765 (xsd:integer) |
| dbp:chemspiderid |
62152 (xsd:integer) |
| dbp:class |
dbr:Progestin dbr:Progestogen_(medication) |
| dbp:drugbank |
DB13129 (en) |
| dbp:eliminationHalfLife |
-72000.0 -56160.0 |
| dbp:h |
30 (xsd:integer) |
| dbp:iupacName |
-17 (xsd:integer) |
| dbp:kegg |
D06235 (en) |
| dbp:legalStatus |
Rx-only (en) |
| dbp:metabolism |
Mainly hydroxylation (en) |
| dbp:o |
3 (xsd:integer) |
| dbp:proteinBound |
98.0 |
| dbp:pubchem |
68926 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Oral_administration |
| dbp:smiles |
C[C@@H]O (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
JUNDJWOLDSCTFK-MTZCLOFQSA-N (en) |
| dbp:synonyms |
TMG; RU-27987; 21-Hydroxypromegestone; 21β-Hydroxypromegestone; 21-Hydroxy-17α,21-dimethyl-9-dehydro-19-norprogesterone; 21-Hydroxy-17α,21-dimethyl-19-norpregna-4,9-dien-3,20-dione; 17β--Lactoyl-17α-methylestra-4,9-dien-3-one; 17β--17α-methylestra-4,9-dien-3-one (en) |
| dbp:title |
dbr:Pharmacodynamics |
| dbp:titlestyle |
background:#ccccff (en) |
| dbp:tradename |
Ginotex, Lovelle, Minique, Ondeva, Totelle, others (en) |
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4658 (xsd:integer) |
| dbp:width |
225 (xsd:integer) |
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dbt:Androgen_receptor_modulators dbt:Cite_journal dbt:Drugbox dbt:Mineralocorticoid_receptor_modulators dbt:Navboxes dbt:Progesterone_receptor_modulators dbt:Reflist dbt:See_also dbt:Short_description dbt:Abbrlink dbt:Progestogens_and_antiprogestogens |
| dcterms:subject |
dbc:Antimineralocorticoids dbc:Dienes dbc:Diketones dbc:Human_drug_metabolites dbc:Progestogens dbc:Secondary_alcohols dbc:Norpregnanes dbc:Antiandrogens |
| gold:hypernym |
dbr:Derivative |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatSteroids yago:Abstraction100002137 yago:BodySubstance105263850 yago:Chemical114806838 yago:Compound114818238 yago:Hormone105407119 yago:LiquidBodySubstance105397468 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Progestin114747338 yago:Relation100031921 dbo:Drug yago:Secretion105404728 yago:Steroid115057744 yago:SteroidHormone114745635 yago:Substance100019613 yago:WikicatProgestogens |
| rdfs:comment |
Trimegestone, sold under the brand names Ondeva and Totelle among others, is a progestin medication which is used in menopausal hormone therapy and in the prevention of postmenopausal osteoporosis. It was also under development for use in birth control pills to prevent pregnancy, but ultimately was not marketed for this purpose. The medication is available alone or in combination with an estrogen. It is taken by mouth. (en) |
| rdfs:label |
Trimegestona (pt) Trimegestone (en) |
| rdfs:seeAlso |
dbr:Progestin dbr:List_of_progestogens |
| owl:sameAs |
freebase:Trimegestone yago-res:Trimegestone wikidata:Trimegestone http://azb.dbpedia.org/resource/تریمقستون dbpedia-fa:Trimegestone dbpedia-pt:Trimegestone dbpedia-sh:Trimegestone dbpedia-sr:Trimegestone dbpedia-vi:Trimegestone https://global.dbpedia.org/id/4wiBz |
| prov:wasDerivedFrom |
wikipedia-en:Trimegestone?oldid=1099019905&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Trimegestone.svg |
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wikipedia-en:Trimegestone |
| is dbo:wikiPageRedirects of |
dbr:Lovelle dbr:Lovelle_Ciclico dbr:Lovelle_Continuo dbr:Lovelle_ciclico dbr:Lovelle_continuo dbr:Ondeva dbr:Totelle dbr:Totelle_Ciclico dbr:Totelle_Ciclo dbr:Totelle_Continuo dbr:Totelle_Continuous dbr:Totelle_Cycle dbr:Totelle_Cyclic dbr:Totelle_Cyclical dbr:Totelle_Cyclo dbr:Totelle_Secuencial dbr:Totelle_Sekvens dbr:Totelle_Sequential dbr:Totelle_ciclico dbr:Totelle_ciclo dbr:Totelle_continuo dbr:Totelle_continuous dbr:Totelle_cycle dbr:Totelle_cyclic dbr:Totelle_cyclical dbr:Totelle_cyclo dbr:Totelle_secuencial dbr:Totelle_sekvens dbr:Totelle_sequential dbr:Ginotex dbr:Minique dbr:PSK-3987 dbr:PSK3987 dbr:PSK_3987 dbr:R-27,987 dbr:R-27987 dbr:R27987 dbr:RU-27,987 dbr:RU-27987 dbr:RU27987 dbr:RU_27,987 dbr:RU_27987 dbr:R_27,987 dbr:R_27987 dbr:21(S)-Hydroxy-17α,21-dimethyl-19-norpregna-4,9-dien-3,20-dione dbr:21(S)-Hydroxypromegestone dbr:21(S)-hydroxypromegestone dbr:21-Hydroxypromegestone dbr:21-hydroxypromegestone dbr:21S-Hydroxypromegestone dbr:21S-hydroxypromegestone dbr:21β-Hydroxypromegestone dbr:21β-hydroxypromegestone |
| is dbo:wikiPageWikiLink of |
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| is foaf:primaryTopic of |
wikipedia-en:Trimegestone |
