Depressogen (original) (raw)
A depressogen is a substance that causes or can cause depression, usually as a side effect. They are the functional opposites of antidepressants. Examples of drugs commonly associated with depressogenic effects include ethanol, some anticonvulsants such as the barbiturates (e.g. phenobarbital), benzodiazepines (e.g. diazepam), vigabatrin, and topiramate, corticosteroids like dexamethasone and prednisone, cytokines like interferon-α and interleukin-2, certain antihypertensives such as amiodarone, clonidine, methyldopa, reserpine, and tetrabenazine (used as an antipsychotic/antihyperkinetic), and agents with antiandrogen, antiestrogen, and/or anti-neurosteroid activities such as GnRH agonists (e.g., leuprorelin, goserelin), anastrozole (an aromatase inhibitor), finasteride (a 5α-reductase in
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| dbo:abstract | A depressogen is a substance that causes or can cause depression, usually as a side effect. They are the functional opposites of antidepressants. Examples of drugs commonly associated with depressogenic effects include ethanol, some anticonvulsants such as the barbiturates (e.g. phenobarbital), benzodiazepines (e.g. diazepam), vigabatrin, and topiramate, corticosteroids like dexamethasone and prednisone, cytokines like interferon-α and interleukin-2, certain antihypertensives such as amiodarone, clonidine, methyldopa, reserpine, and tetrabenazine (used as an antipsychotic/antihyperkinetic), and agents with antiandrogen, antiestrogen, and/or anti-neurosteroid activities such as GnRH agonists (e.g., leuprorelin, goserelin), anastrozole (an aromatase inhibitor), finasteride (a 5α-reductase inhibitor), and clomiphene (a SERM), as well as others including flunarizine, mefloquine, and efavirenz. Another notable agent is rimonabant, a cannabinoid receptor antagonist marketed as an anti-obesity agent which was withdrawn shortly after its introduction due to the incidence of severe psychiatric side effects associated with its use including depression, anxiety, and suicidal ideation. Examples of endogenous compounds that have been implicated in stress and depression include corticotropin-releasing hormone (CRH), cytokines (e.g., interferon-α, interleukin-2), tachykinins (e.g., substance P), glucocorticoids (e.g., cortisol, cortisone), and dynorphin. (en) |
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| dbo:wikiPageWikiLink | dbr:Prednisone dbr:Mood_stabilizer dbr:Benzodiazepines dbr:Bipolar_disorder dbr:Anticonvulsant dbr:Antiestrogen dbr:Anxiogenic dbr:Reserpine dbr:Rimonabant dbr:Cytokine dbr:Vigabatrin dbc:Depressogens dbr:Depressant dbr:Depression_(mood) dbr:Dynorphin dbr:Corticosteroid dbr:Cortisol dbr:Cortisone dbr:Mefloquine dbr:Clomiphene dbr:Clonidine dbr:Efavirenz dbr:Gonadotropin-releasing_hormone_agonist dbr:Goserelin dbr:Corticotropin-releasing_hormone dbr:Antiandrogen dbr:Antidepressant dbr:Antipsychotic dbr:Antipsychotics dbr:Anxiety dbr:Aromatase_inhibitor dbr:Leuprorelin dbr:Substance_P dbr:Barbiturate dbr:Topiramate dbr:Drug dbr:Amiodarone dbr:Anastrozole dbr:Ethanol dbr:Euphoriant dbr:Finasteride dbr:Flunarizine dbr:Glucocorticoid dbr:Endogenous dbr:Tetrabenazine dbr:Hyperkinesia dbr:Stress_(psychological) dbc:Psychoactive_drugs dbr:Dexamethasone dbr:Diazepam dbr:Phenobarbital dbr:Psychiatric dbr:Methyldopa dbr:Cannabinoid_receptor_antagonist dbr:Suicidal_ideation dbr:Mania dbr:Selective_estrogen_receptor_modulator dbr:Side_effect dbr:Neurosteroid dbr:5α-reductase_inhibitor dbr:Antihypertensive dbr:Interferon-α dbr:Interleukin-2 dbr:Anti-obesity_agent dbr:Tachykinin dbr:Withdrawn_drug |
| dbp:date | March 2021 (en) |
| dbp:reason | Convert long prose list to bulleted list. (en) |
| dbp:wikiPageUsesTemplate | dbt:Cleanup dbt:Hatnote dbt:Nervous-system-drug-stub dbt:Reflist |
| dct:subject | dbc:Depressogens dbc:Psychoactive_drugs |
| rdfs:comment | A depressogen is a substance that causes or can cause depression, usually as a side effect. They are the functional opposites of antidepressants. Examples of drugs commonly associated with depressogenic effects include ethanol, some anticonvulsants such as the barbiturates (e.g. phenobarbital), benzodiazepines (e.g. diazepam), vigabatrin, and topiramate, corticosteroids like dexamethasone and prednisone, cytokines like interferon-α and interleukin-2, certain antihypertensives such as amiodarone, clonidine, methyldopa, reserpine, and tetrabenazine (used as an antipsychotic/antihyperkinetic), and agents with antiandrogen, antiestrogen, and/or anti-neurosteroid activities such as GnRH agonists (e.g., leuprorelin, goserelin), anastrozole (an aromatase inhibitor), finasteride (a 5α-reductase in (en) |
| rdfs:label | Depressogen (en) |
| owl:sameAs | wikidata:Depressogen https://global.dbpedia.org/id/4jEGF |
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| is dbo:wikiPageWikiLink of | dbr:Depressogenic dbr:Psychotomimetism dbr:Prodepressive |
| is owl:differentFrom of | dbr:Depressant |
| is foaf:primaryTopic of | wikipedia-en:Depressogen |