Desipramine (original) (raw)
ديسيبرامين (بالإنجليزية: Desipramine) هو دواء مضاد للاكتئاب ثلاثي الحلقات، يعمل مثبطًا انتقائيًا لاسترداد النورإبينفرين.
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| dbo:abstract | ديسيبرامين (بالإنجليزية: Desipramine) هو دواء مضاد للاكتئاب ثلاثي الحلقات، يعمل مثبطًا انتقائيًا لاسترداد النورإبينفرين. (ar) Desipramin ist ein Arzneistoff, der zur Wirkstoffklasse der trizyklischen Antidepressiva zählt. Es wirkt stark antriebssteigernd (thymeretisch) und nach einiger Zeit stimmungsaufhellend (thymoleptisch) und ist zur Behandlung depressiver Erkrankungen angezeigt.Desipramin wurde 1965 unter der Marke Pertofran auf den deutschen Markt gebracht. Heute sind Desipramin-haltige Fertigarzneimittel in den meisten Ländern außer Vertrieb. (de) Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects. The drug is not considered a first-line treatment for depression since the introduction of selective serotonin reuptake inhibitor (SSRI) antidepressants, which have fewer side effects and are safer in overdose. (en) La désipramine, ou déméthylimipramine, est un antidépresseur tricyclique (TCA). Elle inhibe la réabsorption de la noradrénaline et, dans une moindre mesure, de la sérotonine. Elle est utilisée en médication contre la dépression, mais n'est pas considérée comme un traitement de première ligne depuis l'introduction des antidépresseurs ISRS (inhibiteurs sélectifs de la recapture de la sérotonine). La désipramine est un métabolite actif issu de la dégradation de l'imipramine. Avec d'autres antidépresseurs tricycliques, elle peut être utilisée pour traiter des douleurs neuropathiques. Son mode d'action semble impliquer l'inhibition de la réabsorption de la noradrénaline afin d'activer les voies descendantes dans la moelle épinière pour bloquer les signaux douloureux qui remontent au cerveau. La désipramine est l'un des médicaments les plus spécifiques et les plus puissants de ce point de vue. Elle peut également être utilisée comme traitement des symptômes du trouble du déficit de l'attention, la production insuffisante de noradrénaline étant souvent — mais ce point fait toujours l'objet d'âpres débats — associée à ces troubles. (fr) La desipramina, venduta sotto il nome del marchio Norpramin e Pertofrane ed altri, è un antidepressivo triciclico (TCA) e viene nel trattamento della depressione. (it) Dezypramina, dezipramina – organiczny związek chemiczny, lek psychotropowy z grupy TLPD, metabolit ustrojowy imipraminy. Działa jako silny inhibitor wychwytu zwrotnego noradrenaliny przy znikomym wpływie na wychwyt serotoniny. Działa głównie „odhamowująco”, może wyzwalać lęk i niepokój, na innych pacjentów działa raczej tłumiąco. Efekt terapeutyczny pojawia się w pierwszym tygodniu leczenia. (pl) Desipramina é um Antidepressivo tricíclico. Desipramina é o principal Metabólito da Imipramina. Inibe a Recaptação de Noradrenalina seletivamente em dose baixa. Parece ser encontrada somente em Farmácias de Manipulação. Desipramina é um dos antidepressivos tricíclico mais cardiotóxico que existe, por isso caiu em desuso. O seu uso é mais praticado como Analgésico, Adjuvante para Dor Crônica ou Neuropatia Periférica. Muitas vezes serve também para tratar alguns casos de TDAH (Transtorno do Déficit de Atenção com Hiperatividade), apenas como última opção, quando o paciente não puder usar estimulantes - por alguma razão específica. (pt) Desipramin, C18H22N2, antidepressivt medel, patenterat 1962 av . Varunamn i Sverige för preparatet har varit Pertrofrin. Medlet är numera avregistrerat i Sverige. Desipramin är en metabolit till den antidepressiva medicinen imipramin (Tofranil), vilket innebär att imipramin i kroppen ombildas till bland annat desipramin. Desipramin verkar främst genom att minska återuppsuget av signalsubstansen noradrenalin och har enbart en svagare effekt på signalsubstansen serotonin. (sv) Дезипрамин (Desipramine, действующее вещество: N-(3-метиламинопропил)-иминодибензил) — лекарственное средство из группы антидепрессантов. Химически является деметилированным аналогом имипрамина. В организме образуется как естественный его метаболит. Обладает антидепрессивными свойствами. По механизму действия, показаниям к применению и терапевтическому эффекту близок к имипрамину.Побочные явления и противопоказания такие же, как для имипрамина и амитриптилина. Может (хотя и в меньшей степени, чем имипрамин) обострять продуктивную психотическую симптоматику. В России изъят из оборота лекарственных средств. (ru) |
| dbo:alternativeName | Norpramin, Pertofrane, others (en) |
| dbo:bioavailability | 60.000000 (xsd:float) |
| dbo:casNumber | 50-47-5 58-28-6 (hydrochloride) 62265-06-9 (dibudinate) |
| dbo:chEBI | 47781 |
| dbo:chEMBL | 72 |
| dbo:drugbank | DB01151 |
| dbo:fdaUniiCode | TG537D343B |
| dbo:kegg | D07791 |
| dbo:medlinePlus | a682387 |
| dbo:pubchem | 2995 |
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| dbp:alt | Ball-and-stick model of the desipramine molecule (en) Skeletal formula of desipramine (en) |
| dbp:atcPrefix | N06 (en) |
| dbp:atcSuffix | AA01 (en) |
| dbp:bioavailability | 60 (xsd:integer) |
| dbp:c | 18 (xsd:integer) |
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| dbp:casSupplemental | 58 (xsd:integer) 62265 (xsd:integer) |
| dbp:chebi | 47781 (xsd:integer) |
| dbp:chembl | 72 (xsd:integer) |
| dbp:chemspiderid | 2888 (xsd:integer) |
| dbp:drugbank | DB01151 (en) |
| dbp:eliminationHalfLife | -108000.0 |
| dbp:excretion | dbr:Feces dbr:Urine |
| dbp:h | 22 (xsd:integer) |
| dbp:image | Desipramine-3D-balls.png (en) |
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| dbp:legalUs | Rx-only (en) |
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| dbp:metabolism | Liver (en) |
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| dbp:pregnancyUs | N (en) |
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| dbp:routesOfAdministration | dbr:Intramuscular_injection dbr:Oral_administration |
| dbp:smiles | c1cc3cCCc2cN3CCCNC (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | HCYAFALTSJYZDH-UHFFFAOYSA-N (en) |
| dbp:synonyms | Desmethylimipramine; Norimipramine; EX-4355; G-35020; JB-8181; NSC-114901 (en) |
| dbp:title | dbr:Pharmacodynamics |
| dbp:titlestyle | background:#ccccff (en) |
| dbp:tradename | Norpramin, Pertofrane, others (en) |
| dbp:unii | TG537D343B (en) |
| dbp:verifiedrevid | 477166380 (xsd:integer) |
| dbp:width | 200 (xsd:integer) 225 (xsd:integer) |
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| gold:hypernym | dbr:Antidepressant |
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| rdfs:comment | ديسيبرامين (بالإنجليزية: Desipramine) هو دواء مضاد للاكتئاب ثلاثي الحلقات، يعمل مثبطًا انتقائيًا لاسترداد النورإبينفرين. (ar) Desipramin ist ein Arzneistoff, der zur Wirkstoffklasse der trizyklischen Antidepressiva zählt. Es wirkt stark antriebssteigernd (thymeretisch) und nach einiger Zeit stimmungsaufhellend (thymoleptisch) und ist zur Behandlung depressiver Erkrankungen angezeigt.Desipramin wurde 1965 unter der Marke Pertofran auf den deutschen Markt gebracht. Heute sind Desipramin-haltige Fertigarzneimittel in den meisten Ländern außer Vertrieb. (de) Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects. The drug is not considered a first-line treatment for depression since the introduction of selective serotonin reuptake inhibitor (SSRI) antidepressants, which have fewer side effects and are safer in overdose. (en) La desipramina, venduta sotto il nome del marchio Norpramin e Pertofrane ed altri, è un antidepressivo triciclico (TCA) e viene nel trattamento della depressione. (it) Dezypramina, dezipramina – organiczny związek chemiczny, lek psychotropowy z grupy TLPD, metabolit ustrojowy imipraminy. Działa jako silny inhibitor wychwytu zwrotnego noradrenaliny przy znikomym wpływie na wychwyt serotoniny. Działa głównie „odhamowująco”, może wyzwalać lęk i niepokój, na innych pacjentów działa raczej tłumiąco. Efekt terapeutyczny pojawia się w pierwszym tygodniu leczenia. (pl) Desipramina é um Antidepressivo tricíclico. Desipramina é o principal Metabólito da Imipramina. Inibe a Recaptação de Noradrenalina seletivamente em dose baixa. Parece ser encontrada somente em Farmácias de Manipulação. Desipramina é um dos antidepressivos tricíclico mais cardiotóxico que existe, por isso caiu em desuso. O seu uso é mais praticado como Analgésico, Adjuvante para Dor Crônica ou Neuropatia Periférica. Muitas vezes serve também para tratar alguns casos de TDAH (Transtorno do Déficit de Atenção com Hiperatividade), apenas como última opção, quando o paciente não puder usar estimulantes - por alguma razão específica. (pt) Desipramin, C18H22N2, antidepressivt medel, patenterat 1962 av . Varunamn i Sverige för preparatet har varit Pertrofrin. Medlet är numera avregistrerat i Sverige. Desipramin är en metabolit till den antidepressiva medicinen imipramin (Tofranil), vilket innebär att imipramin i kroppen ombildas till bland annat desipramin. Desipramin verkar främst genom att minska återuppsuget av signalsubstansen noradrenalin och har enbart en svagare effekt på signalsubstansen serotonin. (sv) La désipramine, ou déméthylimipramine, est un antidépresseur tricyclique (TCA). Elle inhibe la réabsorption de la noradrénaline et, dans une moindre mesure, de la sérotonine. Elle est utilisée en médication contre la dépression, mais n'est pas considérée comme un traitement de première ligne depuis l'introduction des antidépresseurs ISRS (inhibiteurs sélectifs de la recapture de la sérotonine). (fr) Дезипрамин (Desipramine, действующее вещество: N-(3-метиламинопропил)-иминодибензил) — лекарственное средство из группы антидепрессантов. Химически является деметилированным аналогом имипрамина. В организме образуется как естественный его метаболит. Обладает антидепрессивными свойствами. По механизму действия, показаниям к применению и терапевтическому эффекту близок к имипрамину.Побочные явления и противопоказания такие же, как для имипрамина и амитриптилина. Может (хотя и в меньшей степени, чем имипрамин) обострять продуктивную психотическую симптоматику. (ru) |
| rdfs:label | ديسيبرامين (ar) Desipramine (en) Desipramin (de) Désipramine (fr) Desipramina (it) Dezypramina (pl) Desipramina (pt) Дезипрамин (ru) Desipramin (sv) |
| rdfs:seeAlso | dbr:Pharmacology_of_antidepressants |
| owl:differentFrom | dbr:Depramine |
| owl:sameAs | freebase:Desipramine http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB01151 http://www4.wiwiss.fu-berlin.de/sider/resource/drugs/2995 wikidata:Desipramine dbpedia-ar:Desipramine http://azb.dbpedia.org/resource/دزپپرامین dbpedia-cy:Desipramine dbpedia-de:Desipramine dbpedia-fa:Desipramine dbpedia-fi:Desipramine dbpedia-fr:Desipramine dbpedia-it:Desipramine dbpedia-pl:Desipramine dbpedia-pt:Desipramine dbpedia-ro:Desipramine dbpedia-ru:Desipramine dbpedia-sh:Desipramine dbpedia-sr:Desipramine dbpedia-sv:Desipramine https://global.dbpedia.org/id/3vB2p |
| prov:wasDerivedFrom | wikipedia-en:Desipramine?oldid=1093990643&ns=0 |
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| is owl:differentFrom of | dbr:Depramine |
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