Diproqualone (original) (raw)
Diproqualone is a quinazolinone class GABAergic and is an analogue of methaqualone developed in the late 1950s by a team at Nogentaise de Produits Chimique. It was marketed primarily in France and some other European countries. It has sedative, anxiolytic, antihistamine and analgesic properties, resulting from its agonist activity at the β subtype of the GABAa receptor, antagonist activity at all histamine receptors, inhibition of thecyclooxygenase-1 enzyme, and possibly its agonist activity at both the sigma-1 receptor and sigma-2 receptor (the function of these receptors and their clinical relevance has not yet been determined). Diproqualone is used primarily for the treatment of inflammatory pain associated with osteoarthritis and rheumatoid arthritis, and more rarely for treating insom
| Property | Value |
|---|---|
| dbo:abstract | Diproqualone is a quinazolinone class GABAergic and is an analogue of methaqualone developed in the late 1950s by a team at Nogentaise de Produits Chimique. It was marketed primarily in France and some other European countries. It has sedative, anxiolytic, antihistamine and analgesic properties, resulting from its agonist activity at the β subtype of the GABAa receptor, antagonist activity at all histamine receptors, inhibition of thecyclooxygenase-1 enzyme, and possibly its agonist activity at both the sigma-1 receptor and sigma-2 receptor (the function of these receptors and their clinical relevance has not yet been determined). Diproqualone is used primarily for the treatment of inflammatory pain associated with osteoarthritis and rheumatoid arthritis, and more rarely for treating insomnia, anxiety and neuralgia. Diproqualone is the only analogue of methaqualone that is still in widespread clinical use, due to its useful anti-inflammatory and analgesic effects in addition to the sedative and anxiolytic actions common to other drugs of this class. There are still some concerns about the potential of diproqualone for abuse and overdose, and so it is not sold as a pure drug but only as the camphosulfonate salt in combination mixtures with other medicines such as ethenzamide. (en) |
| dbo:casNumber | 36518-02-2 |
| dbo:fdaUniiCode | QY7HLH8V4L |
| dbo:pubchem | 64112 |
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| dbo:wikiPageWikiLink | dbr:Quinazolinone dbc:Analgesics dbc:Diols dbc:GABAA_receptor_positive_allosteric_modulators dbc:Lactams dbc:Sedatives dbr:Mebroqualone dbr:Mecloqualone dbr:Cloroqualone dbr:Gabaergic dbr:Gamma-Aminobutyric_acid dbr:Antihistamine dbr:Anxiolytic dbr:GABAA_receptor dbr:Afloqualone dbr:Analgesic dbr:Etaqualone dbr:Ethenzamide dbr:Histamine_receptor dbc:Quinazolinones dbr:Methaqualone dbr:Methylmethaqualone dbr:Sedative dbr:Sigma-2_receptor dbr:Sigma-1_receptor dbr:PTGS1 |
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| dbp:casNumber | 36518 (xsd:integer) |
| dbp:chemspiderid | 57691 (xsd:integer) |
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| dbp:iupacName | 3 (xsd:integer) |
| dbp:molecularWeight | 234.251000 (xsd:double) |
| dbp:n | 2 (xsd:integer) |
| dbp:o | 3 (xsd:integer) |
| dbp:pubchem | 64112 (xsd:integer) |
| dbp:smiles | O=C1C2=CC=CC=C2N=CN1CCO (en) |
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| dbp:stdinchikey | NTGLQWGMESPVBV-UHFFFAOYSA-N (en) |
| dbp:unii | QY7HLH8V4L (en) |
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| dbp:watchedfields | changed (en) |
| dbp:width | 200 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:GABAAR_PAMs dbt:Sedatives dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Fdacite dbt:Stdinchicite dbt:Sedative-stub |
| dcterms:subject | dbc:Analgesics dbc:Diols dbc:GABAA_receptor_positive_allosteric_modulators dbc:Lactams dbc:Sedatives dbc:Quinazolinones |
| gold:hypernym | dbr:GABAergic |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAnalgesics yago:WikicatSedatives yago:Agent114778436 yago:Analgesic102707683 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 dbo:Drug yago:Sedative104166553 yago:Substance100020090 umbel-rc:DrugProduct |
| rdfs:comment | Diproqualone is a quinazolinone class GABAergic and is an analogue of methaqualone developed in the late 1950s by a team at Nogentaise de Produits Chimique. It was marketed primarily in France and some other European countries. It has sedative, anxiolytic, antihistamine and analgesic properties, resulting from its agonist activity at the β subtype of the GABAa receptor, antagonist activity at all histamine receptors, inhibition of thecyclooxygenase-1 enzyme, and possibly its agonist activity at both the sigma-1 receptor and sigma-2 receptor (the function of these receptors and their clinical relevance has not yet been determined). Diproqualone is used primarily for the treatment of inflammatory pain associated with osteoarthritis and rheumatoid arthritis, and more rarely for treating insom (en) |
| rdfs:label | Diproqualone (en) |
| owl:sameAs | freebase:Diproqualone yago-res:Diproqualone wikidata:Diproqualone dbpedia-fi:Diproqualone dbpedia-sh:Diproqualone dbpedia-sr:Diproqualone dbpedia-vi:Diproqualone https://global.dbpedia.org/id/4imPt |
| prov:wasDerivedFrom | wikipedia-en:Diproqualone?oldid=1091772450&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Diproqualone.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Diproqualone |
| is dbo:wikiPageWikiLink of | dbr:Quinazolinone dbr:C12H14N2O3 dbr:Depressant dbr:Mebroqualone dbr:Mecloqualone dbr:Cloroqualone dbr:Glycidol dbr:GABAA_receptor dbr:Afloqualone dbr:Etaqualone dbr:Hypnotic dbr:Sedative dbr:List_of_drugs:_Df–Di |
| is foaf:primaryTopic of | wikipedia-en:Diproqualone |
