| dbo:abstract |
Afloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku. It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis. (en) アフロクアロン(Afloqualone)は、キナゾリノン系のGABA作動薬で、1970年代に田辺製薬が開発したのアナログである。β型のGABAA受容体のアゴニストとしての働きに由来する鎮静と筋弛緩剤作用がある。一部臨床用にも用いられているが、感光性のために、皮膚炎等の皮膚疾患が副作用として現れることがある。 (ja) |
| dbo:casNumber |
56287-74-2 |
| dbo:chEMBL |
2105918 |
| dbo:fdaUniiCode |
CO4U2C8ORZ |
| dbo:kegg |
D01638 |
| dbo:pubchem |
2040 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Afloqualone.svg?width=300 |
| dbo:wikiPageID |
13289995 (xsd:integer) |
| dbo:wikiPageLength |
3848 (xsd:nonNegativeInteger) |
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| dbo:wikiPageWikiLink |
dbr:Quinazolinone dbr:Dermatitis dbc:GABAA_receptor_positive_allosteric_modulators dbc:Muscle_relaxants dbc:Organofluorides dbc:Sedatives dbr:Mebroqualone dbr:Mecloqualone dbr:Cloroqualone dbr:Muscle_relaxant dbr:Drug dbr:GABAA_receptor dbr:GABAergic dbr:Etaqualone dbr:Nitromethaqualone dbc:Quinazolinones dbr:Diproqualone dbr:Methaqualone dbr:Methylmethaqualone dbr:Sedative dbr:Photosensitization |
| dbp:atcPrefix |
none (en) |
| dbp:c |
16 (xsd:integer) |
| dbp:casNumber |
56287 (xsd:integer) |
| dbp:chembl |
2105918 (xsd:integer) |
| dbp:chemspiderid |
1960 (xsd:integer) |
| dbp:f |
1 (xsd:integer) |
| dbp:h |
14 (xsd:integer) |
| dbp:iupacName |
6 (xsd:integer) |
| dbp:kegg |
D01638 (en) |
| dbp:legalUs |
Unscheduled (en) |
| dbp:molecularWeight |
283.300000 (xsd:double) |
| dbp:n |
3 (xsd:integer) |
| dbp:o |
1 (xsd:integer) |
| dbp:pubchem |
2040 (xsd:integer) |
| dbp:smiles |
O=C1C2=CC=CC=C2N=CN1C3=CC=CC=C3C (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
VDOSWXIDETXFET-UHFFFAOYSA-N (en) |
| dbp:unii |
CO4U2C8ORZ (en) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
477243444 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:width |
200 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Drugbox dbt:GABAAR_PAMs dbt:Musculoskeletal-drug-stub dbt:Reflist dbt:Sedatives dbt:Short_description dbt:Technical dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Drugs.com dbt:Sedative-stub |
| dcterms:subject |
dbc:GABAA_receptor_positive_allosteric_modulators dbc:Muscle_relaxants dbc:Organofluorides dbc:Sedatives dbc:Quinazolinones |
| gold:hypernym |
dbr:Drug |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatMuscleRelaxants yago:WikicatSedatives yago:Agent114778436 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Matter100020827 yago:Medicine103740161 yago:MuscleRelaxant103800001 yago:PhysicalEntity100001930 yago:Relaxant104072811 dbo:Drug yago:Sedative104166553 yago:Substance100020090 umbel-rc:DrugProduct |
| rdfs:comment |
Afloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku. It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis. (en) アフロクアロン(Afloqualone)は、キナゾリノン系のGABA作動薬で、1970年代に田辺製薬が開発したのアナログである。β型のGABAA受容体のアゴニストとしての働きに由来する鎮静と筋弛緩剤作用がある。一部臨床用にも用いられているが、感光性のために、皮膚炎等の皮膚疾患が副作用として現れることがある。 (ja) |
| rdfs:label |
Afloqualone (en) アフロカロン (ja) |
| owl:sameAs |
freebase:Afloqualone yago-res:Afloqualone wikidata:Afloqualone dbpedia-fi:Afloqualone dbpedia-ja:Afloqualone dbpedia-sh:Afloqualone dbpedia-sr:Afloqualone dbpedia-vi:Afloqualone https://global.dbpedia.org/id/4M6F5 |
| prov:wasDerivedFrom |
wikipedia-en:Afloqualone?oldid=1084703512&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Afloqualone.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Afloqualone |
| is dbo:wikiPageDisambiguates of |
dbr:AFQ |
| is dbo:wikiPageRedirects of |
dbr:C16H14FN3O |
| is dbo:wikiPageWikiLink of |
dbr:List_of_designer_drugs dbr:Depressant dbr:Mebroqualone dbr:Mecloqualone dbr:Cloroqualone dbr:C16H14FN3O dbr:Etaqualone dbr:AFQ dbr:Hypnotic dbr:Diproqualone dbr:Sedative dbr:List_of_drugs:_Ad–Ak |
| is foaf:primaryTopic of |
wikipedia-en:Afloqualone |
