| dbo:abstract |
Dosulepin (INN) ist ein Arzneistoff aus der Gruppe der trizyklischen Antidepressiva. Er wird als Gemisch des cis- und des trans-Isomers meist als Hydrochlorid eingesetzt. (de) Dosulepin, also known as dothiepin and sold under the brand name Prothiaden among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression. Dosulepin was once the most frequently prescribed antidepressant in the United Kingdom, but it is no longer widely used due to its relatively high toxicity in overdose without therapeutic advantages over other TCAs. It acts as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also has other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects. (en) La dosulepina è un composto appartenente alla famiglia degli antidepressivi triciclici, un inibitore non selettivo della ricapatazione neuronale della noradrenalina e della serotonina, dotato di proprietà farmacologiche simili a quelle della demexiptilina e dell'amitriptilina. (it) Dosulepina, dotiepina (łac. Dosulepinum) – trójpierścieniowy lek przeciwdepresyjny, pochodna dibenzotiepiny o słabszym od amitryptyliny działaniu przeciwdepresyjnym, a silniejszym uspokajającym i przeciwlękowym. Nieselektywnie hamuje wychwyt zwrotny noradrenaliny i serotoniny, wykazuje umiarkowane działanie cholinolityczne. Zatrucia mają zwykle ciężki przebieg i są szczególnie niebezpieczne dla życia. Lek szeroko stosowany w niektórych krajach europejskich (m.in. w Wielkiej Brytanii); w polskim lecznictwie obecnie niestosowany. (pl) Dosulepina, também conhecida como dotiepina, é um antidepressivo tricíclico (ADT) utilizado no tratamento da depressão. A dosulepina já foi o antidepressivo mais prescrito no Reino Unido, mas não é mais usado amplamente devido à sua toxicidade relativamente alta em termos de risco de overdose sem vantagens terapêuticas relevantes quando comparada a outros antidepressivos tricíclicos. Ela atua como um inibidor de recaptação de serotonina e noradrenalina (ISRSN) e, além disso, interage com outros neurotransmissores, produzindo efeitos anti-histamínicos, antiadrenérgicos, antisserotonérgicos, anticolinérgicos e também atua como bloqueador os canais de sódio. (pt) |
| dbo:alternativeName |
Prothiaden, others (en) |
| dbo:bioavailability |
30.000000 (xsd:float) |
| dbo:casNumber |
897-15-4 113-53-1 |
| dbo:chEBI |
36803 |
| dbo:chEMBL |
108947 |
| dbo:fdaUniiCode |
3H0042311V W13O82Z7HL |
| dbo:kegg |
D07872 |
| dbo:pubchem |
5284550 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Dosulepin2DACS2.svg?width=300 |
| dbo:wikiPageExternalLink |
https://kidbdev.med.unc.edu/databases/pdsp.php%3FknowID=0&kiKey=&receptorDD=&receptor=&speciesDD=&species=&sourcesDD=&source=&hotLigandDD=&hotLigand=&testLigandDD=&testFreeRadio=testFreeRadio&testLigand=dothiepin&referenceDD=&reference=&KiGreater=&KiLess=&kiAllRadio=all&doQuery=Submit+Query |
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| dbp:atcPrefix |
N06 (en) |
| dbp:atcSuffix |
AA16 (en) |
| dbp:bioavailability |
30.0 |
| dbp:c |
19 (xsd:integer) |
| dbp:casNumber |
897 (xsd:integer) 113-53-1 (en) |
| dbp:chebi |
36803 (xsd:integer) |
| dbp:chembl |
108947 (xsd:integer) |
| dbp:chemspiderid |
4447605 (xsd:integer) |
| dbp:eliminationHalfLife |
-120600.0 -164520.0 -86040.0 -91800.0 |
| dbp:excretion |
Feces: 15% (en) Urine: 56% (en) |
| dbp:h |
21 (xsd:integer) |
| dbp:image |
Dosulepin-from-HCl-1987-xtal-CCDC-1160822.png (en) |
| dbp:index2Label |
HCl (en) |
| dbp:iupacName |
-3 (xsd:integer) |
| dbp:kegg |
D07872 (en) |
| dbp:legalAu |
S4 (en) |
| dbp:metabolism |
Hepatic (en) |
| dbp:metabolites |
Northiaden, dothiepin sulfoxide, northiaden sulfoxide, glucuronide conjugates (en) |
| dbp:n |
1 (xsd:integer) |
| dbp:pregnancyAu |
C (en) |
| dbp:proteinBound |
84.0 |
| dbp:pubchem |
5284550 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Oral_administration |
| dbp:s |
1 (xsd:integer) |
| dbp:smiles |
CNCC/C=C/1\C2=CC=CC=C2CSC3=CC=CC=C31 (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
PHTUQLWOUWZIMZ-GZTJUZNOSA-N (en) |
| dbp:synonyms |
IZ-914, KS-1596 (en) |
| dbp:title |
dbr:Pharmacodynamics |
| dbp:titlestyle |
background:#ccccff (en) |
| dbp:tradename |
Prothiaden, others (en) |
| dbp:unii |
3 (xsd:integer) W13O82Z7HL (en) |
| dbp:usan |
dothiepin (en) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
448788673 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:width |
200 (xsd:integer) 225 (xsd:integer) |
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| dcterms:subject |
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| gold:hypernym |
dbr:Antidepressant |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAmines yago:WikicatAromaticCompounds yago:WikicatSulfurHeterocycles yago:Abstraction100002137 yago:AliphaticCompound114601294 yago:Alkene114713120 yago:Amine114739004 yago:AromaticCompound114610088 yago:Chemical114806838 yago:Compound114818238 yago:HeterocyclicCompound115025397 yago:Hydrocarbon114911057 yago:Material114580897 yago:Matter100020827 yago:MethaneSeries114951377 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Substance100019613 yago:WikicatAlkenes umbel-rc:DrugProduct |
| rdfs:comment |
Dosulepin (INN) ist ein Arzneistoff aus der Gruppe der trizyklischen Antidepressiva. Er wird als Gemisch des cis- und des trans-Isomers meist als Hydrochlorid eingesetzt. (de) Dosulepin, also known as dothiepin and sold under the brand name Prothiaden among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression. Dosulepin was once the most frequently prescribed antidepressant in the United Kingdom, but it is no longer widely used due to its relatively high toxicity in overdose without therapeutic advantages over other TCAs. It acts as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also has other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects. (en) La dosulepina è un composto appartenente alla famiglia degli antidepressivi triciclici, un inibitore non selettivo della ricapatazione neuronale della noradrenalina e della serotonina, dotato di proprietà farmacologiche simili a quelle della demexiptilina e dell'amitriptilina. (it) Dosulepina, dotiepina (łac. Dosulepinum) – trójpierścieniowy lek przeciwdepresyjny, pochodna dibenzotiepiny o słabszym od amitryptyliny działaniu przeciwdepresyjnym, a silniejszym uspokajającym i przeciwlękowym. Nieselektywnie hamuje wychwyt zwrotny noradrenaliny i serotoniny, wykazuje umiarkowane działanie cholinolityczne. Zatrucia mają zwykle ciężki przebieg i są szczególnie niebezpieczne dla życia. Lek szeroko stosowany w niektórych krajach europejskich (m.in. w Wielkiej Brytanii); w polskim lecznictwie obecnie niestosowany. (pl) Dosulepina, também conhecida como dotiepina, é um antidepressivo tricíclico (ADT) utilizado no tratamento da depressão. A dosulepina já foi o antidepressivo mais prescrito no Reino Unido, mas não é mais usado amplamente devido à sua toxicidade relativamente alta em termos de risco de overdose sem vantagens terapêuticas relevantes quando comparada a outros antidepressivos tricíclicos. Ela atua como um inibidor de recaptação de serotonina e noradrenalina (ISRSN) e, além disso, interage com outros neurotransmissores, produzindo efeitos anti-histamínicos, antiadrenérgicos, antisserotonérgicos, anticolinérgicos e também atua como bloqueador os canais de sódio. (pt) |
| rdfs:label |
Dosulepin (de) Dosulepin (en) Dosulepina (it) Dosulepina (pl) Dosulepina (pt) |
| rdfs:seeAlso |
dbr:Pharmacology_of_antidepressants |
| owl:differentFrom |
dbr:Doxepin |
| owl:sameAs |
freebase:Dosulepin yago-res:Dosulepin wikidata:Dosulepin wikidata:Dosulepin http://azb.dbpedia.org/resource/دوسولپین dbpedia-de:Dosulepin dbpedia-fa:Dosulepin dbpedia-it:Dosulepin dbpedia-pl:Dosulepin dbpedia-pt:Dosulepin dbpedia-sh:Dosulepin dbpedia-sr:Dosulepin https://global.dbpedia.org/id/2XypW |
| prov:wasDerivedFrom |
wikipedia-en:Dosulepin?oldid=1058897371&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Dosulepin-from-HCl-1987-xtal-CCDC-1160822.png wiki-commons:Special:FilePath/Dosulepin2DACS2.svg |
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wikipedia-en:Dosulepin |
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