| dbo:abstract |
The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. (en) 真核起始因子4A（英語：eukaryotic translation Initiation Factor 4A，简称为eIF4A）是一种ATP依赖性RNA结合蛋白，一种RNA依赖性ATP酶，和一种RNA解旋酶，它在真核翻译起始进程中发挥重要作用。它被认为可以解开mRNA的5'端非翻译区的二级和三级结构，以使核糖体的附着更容易，同时允许核糖体进行起始密码子扫描。 eIF4A在人体中有三个亚型：eIF4A-1、eIF4A-2和eIF4A-3。 (zh) |
| dbo:arm |
p q |
| dbo:band |
28 13 25.3 |
| dbo:chromosome |
3 17 |
| dbo:ecNumber |
3.6.1.1 |
| dbo:entrezgene |
1973 1974 9775 |
| dbo:hgncid |
3284 3282 18683 |
| dbo:omim |
601102 (xsd:integer) 602641 (xsd:integer) 608546 (xsd:integer) |
| dbo:refseq |
NM_001416 NM_001967 NM_014740 |
| dbo:symbol |
DDX48 EIF4A EIF4A1 EIF4A2 EIF4A3 EIF4F |
| dbo:uniprot |
P38919 P60842 Q14240 |
| dbo:wikiPageID |
20246302 (xsd:integer) |
| dbo:wikiPageLength |
15887 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1107425063 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Rocaglamide dbr:Messenger_RNA dbc:Human_proteins dbr:Gene_expression dbr:Protein_synthesis dbr:Mature_messenger_RNA dbr:Helicase dbr:Amino_acid dbr:DEAD_box dbr:Eukaryote dbr:Protein dbr:RNA dbr:Guanosine_triphosphate dbr:Hippuristanol dbr:EIF3 dbr:EIF4A1 dbr:EIF4A2 dbr:EIF4A3 dbr:EIF4B dbr:EIF4E dbr:EIF4H dbr:Ternary_complex dbr:Model_organism dbr:Regulatory_sequence dbr:Start_codon dbr:Methionine dbr:Cereal_germ dbr:Sea_urchin dbr:Eukaryotic_initiation_factor dbr:Eukaryotic_initiation_factor_4F dbr:Ribosome dbr:Molecular_biology dbr:Phosphorylation dbr:TRNA dbr:Secondary_structure dbr:40S dbr:EIF4F dbr:Splicing_(genetics) |
| dbp:altsymbols |
DDX48 (en) EIF4A (en) EIF4F (en) |
| dbp:arm |
p (en) q (en) |
| dbp:band |
13 (xsd:integer) 25.300000 (xsd:double) 28 (xsd:integer) |
| dbp:chromosome |
3 (xsd:integer) 17 (xsd:integer) |
| dbp:ecnumber |
3.600000 (xsd:double) |
| dbp:entrezgene |
1973 (xsd:integer) 1974 (xsd:integer) 9775 (xsd:integer) |
| dbp:hgncid |
3282 (xsd:integer) 3284 (xsd:integer) 18683 (xsd:integer) |
| dbp:name |
dbr:EIF4A1 dbr:EIF4A2 dbr:EIF4A3 |
| dbp:omim |
601102 (xsd:integer) 602641 (xsd:integer) 608546 (xsd:integer) |
| dbp:refseq |
NM_001416 (en) NM_001967 (en) NM_014740 (en) |
| dbp:symbol |
dbr:EIF4A1 dbr:EIF4A2 dbr:EIF4A3 |
| dbp:uniprot |
P38919 (en) P60842 (en) Q14240 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Reflist dbt:Short_description dbt:Infobox_protein dbt:Lowercase |
| dcterms:subject |
dbc:Human_proteins |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Arrangement107938773 yago:Gene105436752 yago:Group100031264 yago:Ordering108456993 dbo:Protein yago:Sequence108459252 yago:Series108457976 yago:WikicatEukaryoteGenes umbel-rc:ProteinMolecule |
| rdfs:comment |
The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. (en) 真核起始因子4A（英語：eukaryotic translation Initiation Factor 4A，简称为eIF4A）是一种ATP依赖性RNA结合蛋白，一种RNA依赖性ATP酶，和一种RNA解旋酶，它在真核翻译起始进程中发挥重要作用。它被认为可以解开mRNA的5'端非翻译区的二级和三级结构，以使核糖体的附着更容易，同时允许核糖体进行起始密码子扫描。 eIF4A在人体中有三个亚型：eIF4A-1、eIF4A-2和eIF4A-3。 (zh) |
| rdfs:label |
EIF4A (en) EIF4A (zh) |
| owl:sameAs |
freebase:EIF4A yago-res:EIF4A wikidata:EIF4A dbpedia-zh:EIF4A https://global.dbpedia.org/id/4iYYf |
| prov:wasDerivedFrom |
wikipedia-en:EIF4A?oldid=1107425063&ns=0 |
| foaf:isPrimaryTopicOf |
wikipedia-en:EIF4A |
| foaf:name |
eukaryotic translation initiation factor 4A, isoform 1 (en) eukaryotic translation initiation factor 4A, isoform 2 (en) eukaryotic translation initiation factor 4A, isoform 3 (en) |
| is dbo:wikiPageRedirects of |
dbr:Eif4a |
| is dbo:wikiPageWikiLink of |
dbr:Rocaglamide dbr:MTORC1 dbr:Cyclopentenone_prostaglandins dbr:EIF4G dbr:Initiation_factor dbr:Chemoproteomics dbr:Silvestrol dbr:Adenovirus_early_region_1A dbr:43S_preinitiation_complex dbr:Hepatitis_C_virus_internal_ribosome_entry_site dbr:Hippuristanol dbr:EIF4A1 dbr:EIF4B dbr:EIF4E dbr:Chinmoy_Sankar_Dey dbr:BC200_lncRNA dbr:Cap_binding_complex dbr:Stress_granule dbr:Eukaryotic_initiation_factor dbr:Eukaryotic_initiation_factor_4F dbr:Eukaryotic_translation dbr:Eif4a |
| is foaf:primaryTopic of |
wikipedia-en:EIF4A |