Hepatitis C virus internal ribosome entry site (original) (raw)
The Hepatitis C virus internal ribosome entry site, or HCV IRES, is an RNA structure within the 5'UTR of the HCV genome that mediates cap-independent translation initiation. Protein translation of most eukaryotic mRNAs occurs by a cap-dependent mechanism and requires association of Met-tRNAiMet, several eukaryotic initiation factors, and GTP with the 40S ribosomal subunit, recruitment to the 5' cap, and scanning along the 5' UTR to reach to start codon. In contrast, translation of hepatitis C virus (HCV) mRNA is initiated by a different mechanism from the usual 5' cap-binding model. This alternate mechanism relies on the direct binding of the 40S ribosomal subunit by the internal ribosome entry site (IRES) in the 5' UTR of HCV RNA. The HCV IRES adopts a complex structure, and may differ si
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| dbo:abstract | The Hepatitis C virus internal ribosome entry site, or HCV IRES, is an RNA structure within the 5'UTR of the HCV genome that mediates cap-independent translation initiation. Protein translation of most eukaryotic mRNAs occurs by a cap-dependent mechanism and requires association of Met-tRNAiMet, several eukaryotic initiation factors, and GTP with the 40S ribosomal subunit, recruitment to the 5' cap, and scanning along the 5' UTR to reach to start codon. In contrast, translation of hepatitis C virus (HCV) mRNA is initiated by a different mechanism from the usual 5' cap-binding model. This alternate mechanism relies on the direct binding of the 40S ribosomal subunit by the internal ribosome entry site (IRES) in the 5' UTR of HCV RNA. The HCV IRES adopts a complex structure, and may differ significantly from IRES elements identified in picornaviruses. A small number of eukaryotic mRNA have been shown to be translated by internal ribosome entry. (en) |
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| dbp:altsymbols | HCV_IRES (en) |
| dbp:caption | Predicted secondary structure and sequence conservation of IRES_HCV (en) |
| dbp:id | RF00061 (en) |
| dbp:name | Hepatitis C virus internal ribosome entry site (en) |
| dbp:rfam | RF00061 (en) |
| dbp:rnaType | dbr:Internal_ribosome_entry_site dbr:Cis-regulatory_element |
| dbp:symbol | IRES_HCV (en) |
| dbp:taxDomain | Viruses (en) |
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| dct:subject | dbc:Internal_ribosome_entry_site dbc:Hepatitis_C_virus dbc:Cis-regulatory_RNA_elements |
| gold:hypernym | dbr:Structure |
| rdf:type | yago:WikicatCis-regulatoryRNAElements yago:Abstraction100002137 yago:Cognition100023271 yago:Component105868954 yago:Concept105835747 yago:Content105809192 yago:Idea105833840 yago:Part105867413 yago:PsychologicalFeature100023100 dbo:Building |
| rdfs:comment | The Hepatitis C virus internal ribosome entry site, or HCV IRES, is an RNA structure within the 5'UTR of the HCV genome that mediates cap-independent translation initiation. Protein translation of most eukaryotic mRNAs occurs by a cap-dependent mechanism and requires association of Met-tRNAiMet, several eukaryotic initiation factors, and GTP with the 40S ribosomal subunit, recruitment to the 5' cap, and scanning along the 5' UTR to reach to start codon. In contrast, translation of hepatitis C virus (HCV) mRNA is initiated by a different mechanism from the usual 5' cap-binding model. This alternate mechanism relies on the direct binding of the 40S ribosomal subunit by the internal ribosome entry site (IRES) in the 5' UTR of HCV RNA. The HCV IRES adopts a complex structure, and may differ si (en) |
| rdfs:label | Hepatitis C virus internal ribosome entry site (en) |
| owl:sameAs | freebase:Hepatitis C virus internal ribosome entry site yago-res:Hepatitis C virus internal ribosome entry site wikidata:Hepatitis C virus internal ribosome entry site https://global.dbpedia.org/id/4mQce |
| prov:wasDerivedFrom | wikipedia-en:Hepatitis_C_virus_internal_ribosome_entry_site?oldid=1117284218&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/RF00061.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Hepatitis_C_virus_internal_ribosome_entry_site |
| is dbo:wikiPageRedirects of | dbr:HCV_IRES |
| is dbo:wikiPageWikiLink of | dbr:Internal_ribosome_entry_site dbr:Hepatitis_C_virus dbr:HCV_IRES dbr:Eukaryotic_small_ribosomal_subunit_(40S) |
| is foaf:primaryTopic of | wikipedia-en:Hepatitis_C_virus_internal_ribosome_entry_site |
