| dbo:abstract |
EXP-561 is an investigational drug that acts as an inhibitor of the reuptake of serotonin, dopamine, and norepinephrine. It was developed in the 1960s by Du Pont and was suggested as a potential antidepressant but failed in trials and was never marketed. (en) EXP-561，即4-苯基双环[2.2.2]辛-1-胺，是一种有机化合物，化学式为C14H19N。它可以被3-氯过氧苯甲酸氧化为1-硝基-4-苯基双环[2.2.2]辛烷。在碳酸钾的存在下，它可以和1-溴-2-甲氧基乙烷在乙腈中加热反应，得到N-(2-甲氧基乙基)-4-苯基双环[2.2.2]辛-1-胺。 1960年代，它被杜邦公司发展 并被提名为一种抗抑郁药，不过失败了，也没有上市过。 (zh) |
| dbo:casNumber |
10206-89-0 10207-08-6 |
| dbo:fdaUniiCode |
6S9H885MKF |
| dbo:pubchem |
27696 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/EXP-561.svg?width=300 |
| dbo:wikiPageID |
26927153 (xsd:integer) |
| dbo:wikiPageLength |
4173 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1107946588 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Reuptake_inhibitor dbc:Amines dbc:Experimental_drugs dbc:Stimulants dbr:Antidepressant dbc:Antidepressants dbr:Norepinephrine dbc:Serotonin–norepinephrine–dopamine_reuptake_inhibitors dbr:Dopamine dbr:Serotonin dbr:Reuptake dbr:Investigational_drug |
| dbp:atcPrefix |
none (en) |
| dbp:c |
14 (xsd:integer) |
| dbp:casNumber |
10206 (xsd:integer) 10207 (xsd:integer) 16142 (xsd:integer) |
| dbp:chemspiderid |
25769 (xsd:integer) |
| dbp:h |
19 (xsd:integer) |
| dbp:index2Label |
hydrochloride (en) |
| dbp:index3Label |
hydrochloride monohydrate (en) |
| dbp:iupacName |
4 (xsd:integer) |
| dbp:legalStatus |
Uncontrolled (en) |
| dbp:n |
1 (xsd:integer) |
| dbp:pubchem |
27696 (xsd:integer) |
| dbp:routesOfAdministration |
Oral (en) |
| dbp:smiles |
NC12CCCC3=CC=CC=C3 (en) |
| dbp:unii |
6 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Drugbox dbt:Nervous-system-drug-stub dbt:Reflist dbt:Short_description dbt:Stimulants dbt:Cascite dbt:Fdacite dbt:Antidepressants dbt:Monoamine_reuptake_inhibitors |
| dcterms:subject |
dbc:Amines dbc:Experimental_drugs dbc:Stimulants dbc:Antidepressants dbc:Serotonin–norepinephrine–dopamine_reuptake_inhibitors |
| gold:hypernym |
dbr:Drug |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAmines yago:WikicatStimulants yago:Abstraction100002137 yago:AliphaticCompound114601294 yago:Amine114739004 yago:Chemical114806838 yago:Cognition100023271 yago:Compound114818238 yago:Information105816287 yago:Material114580897 yago:Matter100020827 yago:MethaneSeries114951377 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:PsychologicalFeature100023100 yago:Relation100031921 dbo:Drug yago:Stimulation105827684 yago:Substance100019613 |
| rdfs:comment |
EXP-561 is an investigational drug that acts as an inhibitor of the reuptake of serotonin, dopamine, and norepinephrine. It was developed in the 1960s by Du Pont and was suggested as a potential antidepressant but failed in trials and was never marketed. (en) EXP-561，即4-苯基双环[2.2.2]辛-1-胺，是一种有机化合物，化学式为C14H19N。它可以被3-氯过氧苯甲酸氧化为1-硝基-4-苯基双环[2.2.2]辛烷。在碳酸钾的存在下，它可以和1-溴-2-甲氧基乙烷在乙腈中加热反应，得到N-(2-甲氧基乙基)-4-苯基双环[2.2.2]辛-1-胺。 1960年代，它被杜邦公司发展 并被提名为一种抗抑郁药，不过失败了，也没有上市过。 (zh) |
| rdfs:label |
EXP-561 (en) EXP-561 (zh) |
| owl:sameAs |
freebase:EXP-561 yago-res:EXP-561 wikidata:EXP-561 dbpedia-sh:EXP-561 dbpedia-sr:EXP-561 dbpedia-zh:EXP-561 https://global.dbpedia.org/id/4j5RD |
| prov:wasDerivedFrom |
wikipedia-en:EXP-561?oldid=1107946588&ns=0 |
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wiki-commons:Special:FilePath/EXP-561.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:EXP-561 |
| is dbo:wikiPageWikiLink of |
dbr:List_of_adrenergic_drugs dbr:List_of_dopaminergic_drugs dbr:List_of_cocaine_analogues dbr:Tametraline dbr:C14H19N dbr:Serotonin–norepinephrine–dopamine_reuptake_inhibitor |
| is foaf:primaryTopic of |
wikipedia-en:EXP-561 |
