| dbo:abstract |
Echinomycin is a peptide antibiotic. It is a dimer of two peptides creating a cyclic structure. It contains a bicyclic aromatic chromophore that is attached to the dimerized cyclic peptide core and a thioacetal bridge. It intercalates into DNA at two specific sites, thereby blocking the binding of hypoxia inducible factor 1 alpha (HIF1alpha). (en) L'échinomycine ou lévomycine ou quinomycine A est un antibiotique polypeptidique cytotoxique contenant deux substituants quinoxaline qui se lie à l'ADN et inhibe la synthèse des ARN. Il s'intercale dans l'ADN sur deux sites spécifiques, bloquant ainsi la fixation du facteur HIF1alpha (hypoxia inducible factor 1 alpha). (fr) |
| dbo:alternativeName |
Quinomycin A; Levomycin (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Echinomycin.png?width=300 |
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23553315 (xsd:integer) |
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5815 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
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| dbo:wikiPageWikiLink |
dbr:Antibiotic dbr:Peptide dbr:DNA dbr:Intercalation_(biochemistry) dbc:Antibiotics dbr:Antibiotics dbr:Acyl_carrier_protein dbr:Nonribosomal_peptide dbc:Quinoxalines dbr:Thioesterase dbr:Disulfide dbr:Methyltransferase dbr:Nikkomycin dbr:Thioacetal dbr:S-adenosyl-L-methionine dbr:L-tryptophan dbr:Hypoxia_inducible_factor dbr:Adenylation dbr:File:QXC_biosynthesis.png dbr:File:Structure_of_Echinomycin_Biosynthesis.gif dbr:File:Thioacetal_bridge_formation.png |
| dbp:imagefile |
Echinomycin.png (en) |
| dbp:imagesize |
200 (xsd:integer) |
| dbp:othernames |
Quinomycin A; Levomycin (en) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
424800009 (xsd:integer) |
| dbp:watchedfields |
changed (en) |
| dbp:wikiPageUsesTemplate |
dbt:Antibiotic-stub dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Fdacite dbt:Stdinchicite |
| dcterms:subject |
dbc:Antibiotics dbc:Quinoxalines |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatAntibiotics yago:Agent114778436 yago:Antibacterial102716205 yago:Antibiotic102716866 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 dbo:ChemicalCompound yago:Substance100020090 umbel-rc:ChemicalSubstanceType |
| rdfs:comment |
Echinomycin is a peptide antibiotic. It is a dimer of two peptides creating a cyclic structure. It contains a bicyclic aromatic chromophore that is attached to the dimerized cyclic peptide core and a thioacetal bridge. It intercalates into DNA at two specific sites, thereby blocking the binding of hypoxia inducible factor 1 alpha (HIF1alpha). (en) L'échinomycine ou lévomycine ou quinomycine A est un antibiotique polypeptidique cytotoxique contenant deux substituants quinoxaline qui se lie à l'ADN et inhibe la synthèse des ARN. Il s'intercale dans l'ADN sur deux sites spécifiques, bloquant ainsi la fixation du facteur HIF1alpha (hypoxia inducible factor 1 alpha). (fr) |
| rdfs:label |
Echinomycin (en) Échinomycine (fr) |
| owl:sameAs |
freebase:Echinomycin yago-res:Echinomycin wikidata:Echinomycin http://azb.dbpedia.org/resource/اچینومیسین dbpedia-fa:Echinomycin dbpedia-fr:Echinomycin dbpedia-sh:Echinomycin dbpedia-sr:Echinomycin https://global.dbpedia.org/id/2XtEp |
| prov:wasDerivedFrom |
wikipedia-en:Echinomycin?oldid=1093275918&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Echinomycin.png wiki-commons:Special:FilePath/QXC_biosynthesis.png wiki-commons:Special:FilePath/Structure_of_Echinomycin_Biosynthesis.gif wiki-commons:Special:FilePath/Thioacetal_bridge_formation.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:Echinomycin |
| is dbo:wikiPageRedirects of |
dbr:C51H64N12O12S2 |
| is dbo:wikiPageWikiLink of |
dbr:Quinoxaline dbr:List_of_compounds_with_carbon_numbers_50+ dbr:C51H64N12O12S2 dbr:Ceric_ammonium_nitrate dbr:List_of_MeSH_codes_(D03) dbr:List_of_MeSH_codes_(D04) dbr:List_of_MeSH_codes_(D12.644) dbr:Streptomyces_echinatus |
| is foaf:primaryTopic of |
wikipedia-en:Echinomycin |
