| dbo:abstract |
ERAD dráha (ERAD – „endoplasmic reticulum associated degradation“, tedy „degradace spojená s endoplazmatickým retikulem“) je mechanismus, který umožňuje odstranění nefunkčních (poškozených) bílkovin či proteinových komplexů z endoplazmatického retikula (ER). ERAD zabraňuje ukládání takových nefunkčních proteinů v ER a zamezuje, aby tyto proteiny pokračovaly . (cs) Endoplasmic-reticulum-associated protein degradation (ERAD) designates a cellular pathway which targets misfolded proteins of the endoplasmic reticulum for ubiquitination and subsequent degradation by a protein-degrading complex, called the proteasome. (en) 소포체 관련 단백질 분해(小胞體關聯蛋白質分解, 영어: endoplasmic-reticulum-associated protein degradation, ERAD)는 유비퀴틴화 및 프로테아좀이라고 불리는 단백질 분해 복합체에 의한 후속적인 분해를 위해 소포체의 잘못 접혀진 단백질을 표적으로 하는 세포 경로를 지칭한다. (ko) La degradazione delle proteine associata al reticolo endoplasmatico o ERAD (Endoplasmic-reticulum-associated protein degradation) indica un processo cellulare che ha sede nel reticolo endoplasmatico. Tramite l'ERAD si etichettano proteine mal ripiegate (tramite il processo di ubiquitinazione) e le si degradano successivamente per mezzo di un complesso che degrada le proteine, denominato proteasoma. (it) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/ProteinQS_en.svg?width=300 |
| dbo:wikiPageExternalLink |
http://www.landesbioscience.com/journals/auto/abstract.php%3Fid=5190 http://jcs.biologists.org/cgi/reprint/119/21/4373 |
| dbo:wikiPageID |
7241138 (xsd:integer) |
| dbo:wikiPageLength |
13407 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1092909456 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Proteasome dbr:Endoplasmic_reticulum dbr:Membrane_protein dbr:Ubiquitin-activating_enzyme dbr:Cystic_fibrosis dbr:Uridine_diphosphate dbr:Vesicle_(biology_and_chemistry) dbr:Thioester dbr:UGGT dbr:Gene dbr:Glucose dbr:Mutations dbr:Mammalian dbr:Calnexin dbr:Calreticulin dbr:Polypeptide_chain dbr:Protein_subunit dbr:Substrate_(biochemistry) dbc:Cellular_processes dbr:Cell_(biology) dbr:HIV dbr:Lectin dbr:Vpu dbr:Adenosine_triphosphate dbr:Cysteine dbc:Protein_folding dbr:Parkin_(ligase) dbr:Parkinson's_disease dbr:Glucosyltransferase dbr:Glycan dbr:Glycoprotein dbr:Golgi_apparatus dbr:Enzymatic dbr:Protein_folding dbr:Ubiquitin-conjugating_enzyme dbr:Soluble dbr:JUNQ_and_IPOD dbr:Mannose dbr:C-terminus dbr:CD4 dbr:Hydrophobic dbr:Cytosolic dbr:Chaperone_(protein) dbr:Lumen_(anatomy) dbr:Valosin-containing_protein dbr:Oxidative_folding dbr:Lectins dbr:Transmembrane dbr:Ubiquitination dbr:Phosphorylated dbr:Polyubiquitination dbr:File:ProteinQS_en.svg |
| dbp:wikiPageUsesTemplate |
dbt:Citation_needed dbt:Cite_journal dbt:More_footnotes dbt:Refbegin dbt:Refend dbt:Reflist |
| dct:subject |
dbc:Cellular_processes dbc:Protein_folding |
| rdf:type |
yago:WikicatCellularProcesses yago:Abstraction100002137 yago:Act100030358 yago:Activity100407535 yago:Event100029378 yago:Procedure101023820 yago:PsychologicalFeature100023100 yago:YagoPermanentlyLocatedEntity |
| rdfs:comment |
ERAD dráha (ERAD – „endoplasmic reticulum associated degradation“, tedy „degradace spojená s endoplazmatickým retikulem“) je mechanismus, který umožňuje odstranění nefunkčních (poškozených) bílkovin či proteinových komplexů z endoplazmatického retikula (ER). ERAD zabraňuje ukládání takových nefunkčních proteinů v ER a zamezuje, aby tyto proteiny pokračovaly . (cs) Endoplasmic-reticulum-associated protein degradation (ERAD) designates a cellular pathway which targets misfolded proteins of the endoplasmic reticulum for ubiquitination and subsequent degradation by a protein-degrading complex, called the proteasome. (en) 소포체 관련 단백질 분해(小胞體關聯蛋白質分解, 영어: endoplasmic-reticulum-associated protein degradation, ERAD)는 유비퀴틴화 및 프로테아좀이라고 불리는 단백질 분해 복합체에 의한 후속적인 분해를 위해 소포체의 잘못 접혀진 단백질을 표적으로 하는 세포 경로를 지칭한다. (ko) La degradazione delle proteine associata al reticolo endoplasmatico o ERAD (Endoplasmic-reticulum-associated protein degradation) indica un processo cellulare che ha sede nel reticolo endoplasmatico. Tramite l'ERAD si etichettano proteine mal ripiegate (tramite il processo di ubiquitinazione) e le si degradano successivamente per mezzo di un complesso che degrada le proteine, denominato proteasoma. (it) |
| rdfs:label |
ERAD dráha (cs) Endoplasmic-reticulum-associated protein degradation (en) Degradazione delle proteine associata al reticolo endoplasmatico (it) 소포체 관련 단백질 분해 (ko) |
| owl:sameAs |
freebase:Endoplasmic-reticulum-associated protein degradation yago-res:Endoplasmic-reticulum-associated protein degradation wikidata:Endoplasmic-reticulum-associated protein degradation dbpedia-cs:Endoplasmic-reticulum-associated protein degradation dbpedia-it:Endoplasmic-reticulum-associated protein degradation dbpedia-ko:Endoplasmic-reticulum-associated protein degradation https://global.dbpedia.org/id/zQCm |
| skos:closeMatch |
http://www.springernature.com/scigraph/things/subjects/er-associated-degradation |
| prov:wasDerivedFrom |
wikipedia-en:Endoplasmic-reticulum-associated_protein_degradation?oldid=1092909456&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/ProteinQS_en.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Endoplasmic-reticulum-associated_protein_degradation |
| is dbo:wikiPageDisambiguates of |
dbr:Erad |
| is dbo:wikiPageRedirects of |
dbr:Endoplasmic_Reticulum_Associated_Protein_Degradation dbr:Endoplasmic_reticulum-associated_degradation dbr:ERAD |
| is dbo:wikiPageWikiLink of |
dbr:Proteasome dbr:Translocon dbr:Apicoplast dbr:Cystic_fibrosis_transmembrane_conductance_regulator dbr:Ubiquitin_ligase dbr:SEC63 dbr:Derlin-1 dbr:Gap_junction_modulation dbr:Erad dbr:Mitochondrial_unfolded_protein_response dbr:HERPUD1 dbr:Endoplasmic_Reticulum_Associated_Protein_Degradation dbr:Endoplasmic_reticulum-associated_degradation dbr:Sterol-sensing_domain dbr:Ubiquitin dbr:Secretion dbr:Proteostasis dbr:Rhomboid_protease dbr:ERAD |
| is foaf:primaryTopic of |
wikipedia-en:Endoplasmic-reticulum-associated_protein_degradation |
