| dbo:abstract |
In enzymology, an enzyme-thiol transhydrogenase (glutathione-disulfide) (EC 1.8.4.7) is an enzyme that catalyzes the chemical reaction [xanthine dehydrogenase] + glutathione disulfide [xanthine oxidase] + 2 glutathione Thus, the two substrates of this enzyme are xanthine dehydrogenase and glutathione disulfide, whereas its two products are xanthine oxidase and glutathione. This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is [xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductase. Other names in common use include [xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase, enzyme-thiol transhydrogenase (oxidized-glutathione), glutathione-dependent thiol:disulfide oxidoreductase, and thiol:disulfide oxidoreductase. This enzyme participates in glutathione metabolism. (en) La enzima-tiolo transidrogenasi (glutatione-disolfuro) è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: xantina deidrogenasi + glutatione disolfuro ⇄ xantina ossidasi + 2 glutatione L'enzima converte la xantina deidrogenasi numero EC 1.17.1.4 in xantina ossidasi numero EC 1.17.3.2, in presenza di glutatione disolfuro; riduce anche i legami disolfuro della ricina. Non è inibito dal Cu2+ o da reagenti tiolici. (it) 酵素性チオールトランスヒドロゲナーゼ (グルタチオン-ジスルフィド)（enzyme-thiol transhydrogenase (glutathione-disulfide)）は、グルタチオン代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 [キサンチンデヒドロゲナーゼ] + グルタチオンジスルフィド [キサンチンオキシダーゼ] + 2 グルタチオン 反応式の通り、この酵素の基質はキサンチンデヒドロゲナーゼとグルタチオンジスルフィド、生成物はキサンチンオキシダーゼとグルタチオンである。 組織名は[xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductaseで、別名に[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase、enzyme-thiol transhydrogenase (oxidized-glutathione)、glutathione-dependent thiol:disulfide oxidoreductase、thiol:disulphide oxidoreductaseがある。 (ja) |
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| rdfs:comment |
La enzima-tiolo transidrogenasi (glutatione-disolfuro) è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: xantina deidrogenasi + glutatione disolfuro ⇄ xantina ossidasi + 2 glutatione L'enzima converte la xantina deidrogenasi numero EC 1.17.1.4 in xantina ossidasi numero EC 1.17.3.2, in presenza di glutatione disolfuro; riduce anche i legami disolfuro della ricina. Non è inibito dal Cu2+ o da reagenti tiolici. (it) 酵素性チオールトランスヒドロゲナーゼ (グルタチオン-ジスルフィド)（enzyme-thiol transhydrogenase (glutathione-disulfide)）は、グルタチオン代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 [キサンチンデヒドロゲナーゼ] + グルタチオンジスルフィド [キサンチンオキシダーゼ] + 2 グルタチオン 反応式の通り、この酵素の基質はキサンチンデヒドロゲナーゼとグルタチオンジスルフィド、生成物はキサンチンオキシダーゼとグルタチオンである。 組織名は[xanthine-dehydrogenase]:glutathione-disulfide S-oxidoreductaseで、別名に[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase、enzyme-thiol transhydrogenase (oxidized-glutathione)、glutathione-dependent thiol:disulfide oxidoreductase、thiol:disulphide oxidoreductaseがある。 (ja) In enzymology, an enzyme-thiol transhydrogenase (glutathione-disulfide) (EC 1.8.4.7) is an enzyme that catalyzes the chemical reaction [xanthine dehydrogenase] + glutathione disulfide [xanthine oxidase] + 2 glutathione Thus, the two substrates of this enzyme are xanthine dehydrogenase and glutathione disulfide, whereas its two products are xanthine oxidase and glutathione. (en) |
| rdfs:label |
Enzyme-thiol transhydrogenase (glutathione-disulfide) (en) Enzima-tiolo transidrogenasi (glutatione-disolfuro) (it) 酵素性チオールトランスヒドロゲナーゼ (グルタチオン-ジスルフィド) (ja) |
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