Epi-lipoxin (original) (raw)
Le Epilipossine sono derivati dell'acido arachidonico, analoghi alle lipossine, che si formano con il blocco di COX-2.
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| dbo:abstract | Epi-lipoxins are trihydroxy (i.e. containing 3 hydroxyl residues) metabolites of arachidonic acid. They are 15R-epimers of their lipoxin counterparts; that is, the epi-lipoxins, 15-epi-lipoxin A4 (15-epi-LxA4) and 15-epi-lipoxin B4 (15-epi-LXB4), differ from their respective lipoxin A4 (LxA4) and lipoxin B4 (LxB4) epimers in that their 15-hydroxy residue has R rather than S chirality. Formulae for these lipoxins (Lx) are: * LxA4: 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-ETE * LxB4: 5S,14R,15S-trihydroxy-6E,8Z,10E,12E-ETE * 15-epi-LxA4: 5S,6R,15R-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid * 15-epi-LxB4: 5S,14R,15R-trihydroxy-6E,8Z,10E,12E-eicosatrienoic acid The two-epi-Lx's as well as the two lx's are nonclassic eicosanoids that, like other members of the specialized pro-resolving mediators class of autocoids, form during and act to resolve inflammatory responses. Synthesis of the lipoxins typically involves a lipoxygenase enzyme which acts to add a 15S-hydroxyl residue to the lipoxin precursor, arachidonic acid, whereas synthesis of the epi-lipoxins involves aspirin-pretreated cyclooxygenase 2 or a cytochrome P450 enzyme which adds a 15R-hydroxyl residue to arachidonic acid. In acknowledgement of the role played by aspirin-treated cyclooxygenase 2 in forming these products, the epi-lipoxins are sometimes termed ATL which stands for Aspirin-Triggered Lipoxins. The counter-regulatory role of the epi-lipoxins in serving as stop signals for diverse inflammation responses is detailed at the lipoxin site. (en) Le Epilipossine sono derivati dell'acido arachidonico, analoghi alle lipossine, che si formano con il blocco di COX-2. (it) |
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| dbo:wikiPageWikiLink | dbr:Epimer dbr:Cytochrome_P450 dbr:Inflammation dbc:Eicosanoids dbr:Arachidonic_acid dbr:Lipoxin dbr:Chirality dbr:Lipoxygenase dbr:Aspirin dbr:Hydroxyl dbr:Nonclassic_eicosanoid dbr:Autocoid dbr:Specialized_pro-resolving_mediators dbr:Cyclooxygenase_2 |
| dbp:wikiPageUsesTemplate | dbt:Eicosanoids dbt:Biochem-stub |
| dcterms:subject | dbc:Eicosanoids |
| gold:hypernym | dbr:Epimers |
| rdfs:comment | Le Epilipossine sono derivati dell'acido arachidonico, analoghi alle lipossine, che si formano con il blocco di COX-2. (it) Epi-lipoxins are trihydroxy (i.e. containing 3 hydroxyl residues) metabolites of arachidonic acid. They are 15R-epimers of their lipoxin counterparts; that is, the epi-lipoxins, 15-epi-lipoxin A4 (15-epi-LxA4) and 15-epi-lipoxin B4 (15-epi-LXB4), differ from their respective lipoxin A4 (LxA4) and lipoxin B4 (LxB4) epimers in that their 15-hydroxy residue has R rather than S chirality. Formulae for these lipoxins (Lx) are: The counter-regulatory role of the epi-lipoxins in serving as stop signals for diverse inflammation responses is detailed at the lipoxin site. (en) |
| rdfs:label | Epi-lipoxin (en) Epilipossine (it) |
| owl:sameAs | freebase:Epi-lipoxin wikidata:Epi-lipoxin wikidata:Epi-lipoxin dbpedia-it:Epi-lipoxin dbpedia-sh:Epi-lipoxin dbpedia-sr:Epi-lipoxin https://global.dbpedia.org/id/4jS1v |
| prov:wasDerivedFrom | wikipedia-en:Epi-lipoxin?oldid=1048626394&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Epi-lipoxin |
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| is foaf:primaryTopic of | wikipedia-en:Epi-lipoxin |