Examples of in vitro transdifferentiation by lineage-instructive approach (original) (raw)
A list of examples of transdifferentiation: * Mouse fibroblasts, chondroblasts, and pigmented retinal epithelial cells → myoblasts (MyoD) * Fibroblasts → melanocytes (MITF) * Glial cells → neurons (Pax6) * Erythorid-megakaryocytic cells → monocytic cells (SPI1/PU.1) * B-cell progenitors → functional macrophages (C/EBPα) * Rat hepatic cell line → insulin-producing cells (Pdx1 and Ngn3) * Fibroblasts → macrophage-like cells (PU.1 and C/EBPα or C/EBPβ) * Postnatal cardiac and dermal fibroblasts → cardiomyocytes (Gata4, myocyte enhancer factor 2C, and Tbx5) * Fibroblasts → heptaocyte-like cells (Gata4, Hnf1alpha, and Foxa3) or (Hnf4alpha and Foxa1, Foxa2 or Foxa3) * Fibroblasts → neurons (Ascl1, Pou3f2/Brn2, and Myt1l) * Human fibroblasts → neurons (Ascl1, Brn2, Mytl1, and NeuroD) o
| Property | Value |
|---|---|
| dbo:abstract | A list of examples of transdifferentiation: * Mouse fibroblasts, chondroblasts, and pigmented retinal epithelial cells → myoblasts (MyoD) * Fibroblasts → melanocytes (MITF) * Glial cells → neurons (Pax6) * Erythorid-megakaryocytic cells → monocytic cells (SPI1/PU.1) * B-cell progenitors → functional macrophages (C/EBPα) * Rat hepatic cell line → insulin-producing cells (Pdx1 and Ngn3) * Fibroblasts → macrophage-like cells (PU.1 and C/EBPα or C/EBPβ) * Postnatal cardiac and dermal fibroblasts → cardiomyocytes (Gata4, myocyte enhancer factor 2C, and Tbx5) * Fibroblasts → heptaocyte-like cells (Gata4, Hnf1alpha, and Foxa3) or (Hnf4alpha and Foxa1, Foxa2 or Foxa3) * Fibroblasts → neurons (Ascl1, Pou3f2/Brn2, and Myt1l) * Human fibroblasts → neurons (Ascl1, Brn2, Mytl1, and NeuroD) or (miR-9/9-124, Neurod2, Ascl1, and Myt1l) * Human fibroblasts → functional neurons (miR-124, Myt1l and Brn2) * Fibroblasts → dopaminergic neurons (Ascl1, Brn2, Myt1l, Lmx1a, and FoxA2) or (Ascl1, Nurr1, and Lmx1a) * Astrocytes → dopaminergic neurons (Ascl1, Lmx1b, Nurr1) (en) |
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| dbo:wikiPageWikiLink | dbr:Epithelium dbr:Neurogenins dbr:Induced_stem_cells dbr:Pdx1 dbr:Mir-124_microRNA_precursor_family dbr:Chondroblast dbr:GATA4 dbr:ASCL1 dbc:Induced_stem_cells dbc:Histology dbr:Fibroblast dbr:FOXA1 dbr:FOXA2 dbr:FOXA3 dbr:Ccaat-enhancer-binding_proteins dbr:SPI1 dbr:TBX5_(gene) dbr:Transdifferentiation dbr:MyoD dbr:PAX6 dbr:Myoblast dbr:MITF |
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| rdfs:comment | A list of examples of transdifferentiation: * Mouse fibroblasts, chondroblasts, and pigmented retinal epithelial cells → myoblasts (MyoD) * Fibroblasts → melanocytes (MITF) * Glial cells → neurons (Pax6) * Erythorid-megakaryocytic cells → monocytic cells (SPI1/PU.1) * B-cell progenitors → functional macrophages (C/EBPα) * Rat hepatic cell line → insulin-producing cells (Pdx1 and Ngn3) * Fibroblasts → macrophage-like cells (PU.1 and C/EBPα or C/EBPβ) * Postnatal cardiac and dermal fibroblasts → cardiomyocytes (Gata4, myocyte enhancer factor 2C, and Tbx5) * Fibroblasts → heptaocyte-like cells (Gata4, Hnf1alpha, and Foxa3) or (Hnf4alpha and Foxa1, Foxa2 or Foxa3) * Fibroblasts → neurons (Ascl1, Pou3f2/Brn2, and Myt1l) * Human fibroblasts → neurons (Ascl1, Brn2, Mytl1, and NeuroD) o (en) |
| rdfs:label | Examples of in vitro transdifferentiation by lineage-instructive approach (en) |
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