Fatty acid-binding protein (original) (raw)
Le proteine leganti gli acidi grassi o FABP (acronimo dall'inglese fatty acid binding proteins), sono una famiglia di proteine che hanno la capacità di legare gli acidi grassi e di favorirne il trasporto attraverso la membrana cellulare. Sono conosciuti 9 tipi di FABP, ciascuna espressa in diversi organi. La prima descrizione di un trasportatore di acidi grassi si deve ad Harmon e Abumrad.
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| dbo:abstract | The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR. The FABPs are intracellular carriers that “solubilize” the endocannabinoid anandamide (AEA), transporting AEA to the breakdown by FAAH, and compounds that bind to FABPs block AEA breakdown, raising its level. The cannabinoids (THC and CBD) are also discovered to bind human FABPs (1, 3, 5, and 7) that function as intracellular carriers, as THC and CBD inhibit the cellular uptake and catabolism of AEA by targeting FABPs. Competition for FABPs may in part or wholly explain the increased circulating levels of endocannabinoids reported after consumption of cannabinoids. Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity. (en) Les protéines de liaison aux acides gras (FABP) constituent une famille de pour les acides gras et d'autres substances lipophiles telles que les eicosanoïdes et les rétinoïdes. On pense que ces protéines facilitent le transfert des acides gras entre les membranes extra et intracellulaires. On pense également que certains membres de la famille transportent des molécules lipophiles de la membrane cellulaire externe vers certains récepteurs intracellulaires tels que les PPAR. Les FABP sont des transporteurs intracellulaires qui «solubilisent» l' anandamide (AEA), transportant l'AEA vers la décomposition par FAAH, et les composés qui se lient aux FABP bloquent le catabolisme de l'AEA, augmentant ainsi son niveau. On a également découvert que les cannabinoïdes (THC et CBD) se lient aux FABP humaines (1, 3, 5 et 7) qui fonctionnent comme , car le THC et le CBD inhibent l’ et le catabolisme de l’AEA en ciblant les FABP. La compétition pour les FABP peut expliquer en partie ou en totalité l'augmentation des taux circulants d'endocannabinoïdes rapportés après la consommation de cannabinoïdes. Il a été démontré que les niveaux de protéines liant les acides gras diminuaient avec le vieillissement dans le cerveau de souris, contribuant probablement au déclin de l'activité synaptique associé à l'âge. (fr) Le proteine leganti gli acidi grassi o FABP (acronimo dall'inglese fatty acid binding proteins), sono una famiglia di proteine che hanno la capacità di legare gli acidi grassi e di favorirne il trasporto attraverso la membrana cellulare. Sono conosciuti 9 tipi di FABP, ciascuna espressa in diversi organi. La prima descrizione di un trasportatore di acidi grassi si deve ad Harmon e Abumrad. (it) Белки, связывающие жирные кислоты (англ. fatty-acid-binding proteins, FABP; БСЖК) — семейство транспортеров жирных кислот и других липофильных веществ, таких как эйкозаноиды и ретиноиды. Как считается, эти белки способствуют переносу жирных кислот сквозь вне- и внутриклеточные мембраны. Некоторые БСЖК предположительно обеспечивают транспорт липофильных молекул от внешней клеточной мембраны к внутриклеточным рецепторам, таким как PPAR. (ru) |
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| rdfs:comment | Le proteine leganti gli acidi grassi o FABP (acronimo dall'inglese fatty acid binding proteins), sono una famiglia di proteine che hanno la capacità di legare gli acidi grassi e di favorirne il trasporto attraverso la membrana cellulare. Sono conosciuti 9 tipi di FABP, ciascuna espressa in diversi organi. La prima descrizione di un trasportatore di acidi grassi si deve ad Harmon e Abumrad. (it) Белки, связывающие жирные кислоты (англ. fatty-acid-binding proteins, FABP; БСЖК) — семейство транспортеров жирных кислот и других липофильных веществ, таких как эйкозаноиды и ретиноиды. Как считается, эти белки способствуют переносу жирных кислот сквозь вне- и внутриклеточные мембраны. Некоторые БСЖК предположительно обеспечивают транспорт липофильных молекул от внешней клеточной мембраны к внутриклеточным рецепторам, таким как PPAR. (ru) The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR. The FABPs are intracellular carriers that “solubilize” the endocannabinoid anandamide (AEA), transporting AEA to the breakdown by FAAH, and compounds that bind to FABPs block AEA breakdown, raising its level. The cannabinoids (THC and CBD) are also discovered to bind human FABPs (1, 3, 5, and 7) that function as intracellular carriers, as THC and CBD inhibit the cellular uptake an (en) Les protéines de liaison aux acides gras (FABP) constituent une famille de pour les acides gras et d'autres substances lipophiles telles que les eicosanoïdes et les rétinoïdes. On pense que ces protéines facilitent le transfert des acides gras entre les membranes extra et intracellulaires. On pense également que certains membres de la famille transportent des molécules lipophiles de la membrane cellulaire externe vers certains récepteurs intracellulaires tels que les PPAR. Les FABP sont des transporteurs intracellulaires qui «solubilisent» l' anandamide (AEA), transportant l'AEA vers la décomposition par FAAH, et les composés qui se lient aux FABP bloquent le catabolisme de l'AEA, augmentant ainsi son niveau. On a également découvert que les cannabinoïdes (THC et CBD) se lient aux FABP hu (fr) |
| rdfs:label | Protéine de liaison aux acides gras (fr) Fatty acid-binding protein (en) Proteina legante gli acidi grassi (it) Белок, связывающий жирные кислоты (ru) |
| rdfs:seeAlso | dbr:Pseudogene |
| owl:sameAs | freebase:Fatty acid-binding protein yago-res:Fatty acid-binding protein wikidata:Fatty acid-binding protein dbpedia-fr:Fatty acid-binding protein dbpedia-it:Fatty acid-binding protein dbpedia-ru:Fatty acid-binding protein https://global.dbpedia.org/id/3n4dW |
| prov:wasDerivedFrom | wikipedia-en:Fatty_acid-binding_protein?oldid=1043973108&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Protein_FABP3_PDB_1g5w.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Fatty_acid-binding_protein |
| is dbo:wikiPageDisambiguates of | dbr:Binding_protein |
| is dbo:wikiPageRedirects of | dbr:Fatty_acid–binding_protein dbr:FABP dbr:Fatty_acid_binding_protein |
| is dbo:wikiPageWikiLink of | dbr:Endocannabinoid_transporter dbr:FABP1 dbr:FABP5 dbr:Small_intestine dbr:2-Arachidonoylglycerol dbr:Adipocyte_protein_2 dbr:Adipose_tissue_macrophages dbr:Heart-type_fatty_acid_binding_protein dbr:Anandamide dbr:Fatty_acid–binding_protein dbr:Guide_to_Pharmacology dbr:Binding_protein dbr:FABP dbr:FABP2 dbr:Tardigrade_specific_proteins dbr:Fatty_acid_binding_protein |
| is foaf:primaryTopic of | wikipedia-en:Fatty_acid-binding_protein |
