| dbo:abstract |
Fedotozine (INN; JO 1196 for the (-) tartrate salt) is an opioid drug of the arylacetamide series which acts as a peripherally specific selective κ1-opioid receptor agonist with preference for the κ1A subtype. It was under investigation for the treatment of gastrointestinal conditions like irritable bowel syndrome and functional dyspepsia and made it to phase III clinical trials, but ultimately development was discontinued and it was never marketed. (en) |
| dbo:casNumber |
123618-00-8 133267-27-3 (tartrate) |
| dbo:chEMBL |
2106275 |
| dbo:fdaUniiCode |
F45VW2087W |
| dbo:pubchem |
6918160 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Fedotozine_structure.svg?width=300 |
| dbo:wikiPageID |
35582885 (xsd:integer) |
| dbo:wikiPageLength |
3094 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1051001607 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbc:Abandoned_drugs dbc:Acetamides dbc:Analgesics dbc:Opioids dbr:Medical_condition dbr:Oral_administration dbr:Phase_III_clinical_trials dbc:Kappa-opioid_receptor_agonists dbr:Clinical_trial dbr:Gastrointestinal dbc:Peripherally_selective_drugs dbr:Trimebutine dbr:Drug dbr:Irritable_bowel_syndrome dbr:Agonist dbr:International_Nonproprietary_Name dbr:Tartrate dbr:Asimadoline dbr:Binding_selectivity dbr:Opioid dbr:Κ-opioid_receptor dbr:Peripheral dbr:Functional_dyspepsia dbr:Arylacetamide |
| dbp:atcPrefix |
None (en) |
| dbp:c |
22 (xsd:integer) |
| dbp:casNumber |
123618 (xsd:integer) |
| dbp:casSupplemental |
133267 (xsd:integer) |
| dbp:chembl |
2106275 (xsd:integer) |
| dbp:chemspiderid |
5293373 (xsd:integer) |
| dbp:h |
31 (xsd:integer) |
| dbp:iupacName |
-N,N-dimethyl-2-phenyl-1-[oxy]-2-butanamine (en) |
| dbp:legalStatus |
Non-regulated (en) |
| dbp:n |
1 (xsd:integer) |
| dbp:o |
4 (xsd:integer) |
| dbp:pubchem |
6918160 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Oral_administration |
| dbp:smiles |
OC (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
MVKIWCDXKCUDEH-QFIPXVFZSA-N (en) |
| dbp:unii |
F45VW2087W (en) |
| dbp:wikiPageUsesTemplate |
dbt:Drugbox dbt:Opioidergics dbt:Reflist dbt:Fdacite dbt:Drugs_for_functional_gastrointestinal_disorders |
| dct:subject |
dbc:Abandoned_drugs dbc:Acetamides dbc:Analgesics dbc:Opioids dbc:Kappa-opioid_receptor_agonists dbc:Peripherally_selective_drugs |
| gold:hypernym |
dbr:Drug |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Acetamide114711197 yago:Amide114724264 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Statement106722453 yago:Substance100019613 yago:WikicatAcetamides |
| rdfs:comment |
Fedotozine (INN; JO 1196 for the (-) tartrate salt) is an opioid drug of the arylacetamide series which acts as a peripherally specific selective κ1-opioid receptor agonist with preference for the κ1A subtype. It was under investigation for the treatment of gastrointestinal conditions like irritable bowel syndrome and functional dyspepsia and made it to phase III clinical trials, but ultimately development was discontinued and it was never marketed. (en) |
| rdfs:label |
Fedotozine (en) |
| owl:sameAs |
freebase:Fedotozine yago-res:Fedotozine wikidata:Fedotozine dbpedia-sh:Fedotozine dbpedia-sr:Fedotozine https://global.dbpedia.org/id/4jpdu |
| prov:wasDerivedFrom |
wikipedia-en:Fedotozine?oldid=1051001607&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Fedotozine_structure.svg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Fedotozine |
| is dbo:wikiPageRedirects of |
dbr:C22H31NO4 |
| is dbo:wikiPageWikiLink of |
dbr:List_of_opioids dbr:C22H31NO4 dbr:Trimebutine dbr:Asimadoline dbr:Κ-opioid_receptor dbr:List_of_drugs:_Fe |
| is foaf:primaryTopic of |
wikipedia-en:Fedotozine |
