3-Galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase (original) (raw)
In enzymology, a 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase (EC 2.4.1.65) is an enzyme that catalyzes the chemical reaction GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D- glucosaminyl-R Thus, the two substrates of this enzyme are and [[beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R]], whereas its 3 products are GDP, [[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-]], and . This enzyme participates in 3 metabolic pathways: , , and .
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| dbo:abstract | In enzymology, a 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase (EC 2.4.1.65) is an enzyme that catalyzes the chemical reaction GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D- glucosaminyl-R Thus, the two substrates of this enzyme are and [[beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R]], whereas its 3 products are GDP, [[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-]], and . This enzyme participates in 3 metabolic pathways: , , and . (en) La 3-galattosil-N-acetilglucosaminide 4-alfa-L-fucosiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: GDP-β-L-fucosio + β-D-galattosil-(1→3)-N-acetil-D-glucosamminil-R ⇄ GDP + β-D-galattosil-(1→3)-[α-L-fucosil-(1→4)]-N-acetil-β-D-glucosaminil-R Questo enzima è il prodotto del gene del gruppo sanguigno di Lewis. Normalmente agisce sul glicoconiugato, mentre R (vedi la reazione) è una glicoproteina o un glicolipide. Benché sia una 4-fucosiltransferasi, ha una persistente attività di 3-fucosiltransferasi verso il di glucosio nel lattosio libero. Questo enzima fucosila sul O-4 di una N-acetilglucosammina che trasporta un gruppo galattosile sul O-3, a differenza della (numero EC 2.4.1.152), che fucosila sul O-3 di una N-acetilglucosammina che carica un gruppo galattosile sul O-4. Enzimi che catalizzano la 4-α-fucosilazione della GlcNAc delle β-D-Gal-(1→3)-β;-GlcNAc sequenze (con una piccola attività di 3-α-fucosiltransferasi) sono presenti nelle piante, mentre la funzione in vivo è la modificazione degli N-glicani. In aggiunta, il gene fucTa del ceppo UA948 dell'Helicobacter codifica una fucosiltransferasi con l'attività di 3-α- e 4-α-fucosiltransferasi. (it) |
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| dcterms:subject | dbc:EC_2.4.1 dbc:Enzymes_of_unknown_structure |
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| rdfs:comment | In enzymology, a 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase (EC 2.4.1.65) is an enzyme that catalyzes the chemical reaction GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D- glucosaminyl-R Thus, the two substrates of this enzyme are and [[beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R]], whereas its 3 products are GDP, [[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-]], and . This enzyme participates in 3 metabolic pathways: , , and . (en) La 3-galattosil-N-acetilglucosaminide 4-alfa-L-fucosiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: GDP-β-L-fucosio + β-D-galattosil-(1→3)-N-acetil-D-glucosamminil-R ⇄ GDP + β-D-galattosil-(1→3)-[α-L-fucosil-(1→4)]-N-acetil-β-D-glucosaminil-R (it) |
| rdfs:label | 3-Galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase (en) 3-galattosil-N-acetilglucosaminide 4-alfa-L-fucosiltransferasi (it) |
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