HEAT repeat (original) (raw)
A HEAT repeat is a protein tandem repeat structural motif composed of two alpha helices linked by a short loop. HEAT repeats can form alpha solenoids, a type of solenoid protein domain found in a number of cytoplasmic proteins. The name "HEAT" is an acronym for four proteins in which this repeat structure is found: Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1. HEAT repeats form extended superhelical structures which are often involved in intracellular transport; they are structurally related to armadillo repeats. The nuclear transport protein importin beta contains 19 HEAT repeats.
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| dbo:abstract | A HEAT repeat is a protein tandem repeat structural motif composed of two alpha helices linked by a short loop. HEAT repeats can form alpha solenoids, a type of solenoid protein domain found in a number of cytoplasmic proteins. The name "HEAT" is an acronym for four proteins in which this repeat structure is found: Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1. HEAT repeats form extended superhelical structures which are often involved in intracellular transport; they are structurally related to armadillo repeats. The nuclear transport protein importin beta contains 19 HEAT repeats. (en) Une répétition HEAT est un motif structurel constitué de répétitions en tandem au sein de certaines protéines, formée de deux hélices α liées par une petite boucle. Les répétitions HEAT peuvent former des solénoïdes α, structures courantes dans les protéines cytoplasmiques. Le nom « HEAT » provient de quatre protéines possédant ce type motif : l'huntingtine (H), le (en) (E), la protéine phosphatase 2A (A) et la kinase Tor1 (T). Les répétitions HEAT forment des structures en superhélice qui interviennent souvent dans le transport intercellulaire. Elles sont structurellement apparentées aux répétitions armadillo. L'importine β, par exemple, contient 19 répétitions HEAT. (fr) HEATリピート（ひーとりぴーと：HEAT repeats）は、多くのタンパク質に見られるリピート配列（構造）のひとつ。ひとつのユニットは、30-40アミノ酸残基からなり、2本の両親媒性ヘリックスが折り畳まれた構造をつくる。このユニットが数十回繰り返されると、弾力性に富むソレノイド状構造を形成する。 (ja) |
| dbo:symbol | HEAT |
| dbo:thumbnail | wiki-commons:Special:FilePath/Alpha_solenoid_pp2a_2...th_single_repeat_center.png?width=300 |
| dbo:wikiPageID | 19472048 (xsd:integer) |
| dbo:wikiPageLength | 25014 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1122847475 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Aminoacyl_tRNA_synthetase dbr:Proteasome dbr:Protein_phosphatase_2 dbr:Structural_motif dbr:Armadillo_repeats dbr:Cytoplasm dbr:KPNB1 dbr:Protein_tandem_repeats dbr:Condensin dbr:Alpha_helices dbr:Transcriptional_regulation dbr:Alpha_solenoid dbr:Fanconi_anemia dbr:Helix-turn-helix dbr:Huntingtin dbr:Cohesin dbr:C-terminus dbr:Microtubule dbr:Solenoid_protein_domain dbr:Ubiquitin dbr:Importin dbr:N-terminus dbr:Translational_regulation dbr:Protein_phosphatase_2A dbr:W:Ataxia_telangiectasia_and_Rad3_related dbr:W:Ataxia_telangiectasia_mutated dbr:W:DNA-PKcs dbr:W:FANCF dbr:W:target_of_rapamycin |
| dbp:caption | An example of an alpha solenoid structure composed of 15 HEAT repeats. The protein phosphatase 2A regulatory subunit is shown with the N-terminus in blue at bottom and the C-terminus in red at top. A single helix-turn-helix motif is shown in the center with the outer helix in pink, the inner helix in green, and the turn in white. From . (en) |
| dbp:interpro | IPR000357 (en) |
| dbp:name | HEAT repeat (en) |
| dbp:pdb | , , , , , , , , , , , (en) |
| dbp:pfam | PF02985 (en) |
| dbp:prosite | PDOC50077 (en) |
| dbp:scop | 1 (xsd:integer) |
| dbp:symbol | HEAT (en) |
| dbp:wikiPageUsesTemplate | dbt:ELM dbt:Reflist dbt:Short_description dbt:PDB2 dbt:Protein_tandem_repeats dbt:PDB dbt:Pfam_box |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 dbo:Protein |
| rdfs:comment | A HEAT repeat is a protein tandem repeat structural motif composed of two alpha helices linked by a short loop. HEAT repeats can form alpha solenoids, a type of solenoid protein domain found in a number of cytoplasmic proteins. The name "HEAT" is an acronym for four proteins in which this repeat structure is found: Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1. HEAT repeats form extended superhelical structures which are often involved in intracellular transport; they are structurally related to armadillo repeats. The nuclear transport protein importin beta contains 19 HEAT repeats. (en) Une répétition HEAT est un motif structurel constitué de répétitions en tandem au sein de certaines protéines, formée de deux hélices α liées par une petite boucle. Les répétitions HEAT peuvent former des solénoïdes α, structures courantes dans les protéines cytoplasmiques. Le nom « HEAT » provient de quatre protéines possédant ce type motif : l'huntingtine (H), le (en) (E), la protéine phosphatase 2A (A) et la kinase Tor1 (T). Les répétitions HEAT forment des structures en superhélice qui interviennent souvent dans le transport intercellulaire. Elles sont structurellement apparentées aux répétitions armadillo. L'importine β, par exemple, contient 19 répétitions HEAT. (fr) HEATリピート（ひーとりぴーと：HEAT repeats）は、多くのタンパク質に見られるリピート配列（構造）のひとつ。ひとつのユニットは、30-40アミノ酸残基からなり、2本の両親媒性ヘリックスが折り畳まれた構造をつくる。このユニットが数十回繰り返されると、弾力性に富むソレノイド状構造を形成する。 (ja) |
| rdfs:label | HEAT repeat (en) Répétition HEAT (fr) HEATリピート (ja) |
| owl:sameAs | wikidata:HEAT repeat dbpedia-fr:HEAT repeat dbpedia-ja:HEAT repeat dbpedia-sh:HEAT repeat dbpedia-sr:HEAT repeat https://global.dbpedia.org/id/2KTSq |
| prov:wasDerivedFrom | wikipedia-en:HEAT_repeat?oldid=1122847475&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Alpha_solenoid_pp2a_2iae_with_single_repeat_center.png |
| foaf:isPrimaryTopicOf | wikipedia-en:HEAT_repeat |
| is dbo:wikiPageDisambiguates of | dbr:Heat_(disambiguation) |
| is dbo:wikiPageRedirects of | dbr:Heat_repeat_domain dbr:HEAT_repeat_domain dbr:HEAT_motif |
| is dbo:wikiPageWikiLink of | dbr:Condensin dbr:Phragmoplast dbr:Heat_repeat_domain dbr:Alpha_solenoid dbr:IPO5 dbr:HEAT_repeat_domain dbr:HEAT_motif dbr:Heat_(disambiguation) dbr:SF3B1 dbr:NIPBL dbr:TELO2 dbr:SARM1 |
| is foaf:primaryTopic of | wikipedia-en:HEAT_repeat |
