| dbo:abstract |
Not to be confused with Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors Hypoxia-inducible factor prolyl hydroxylase Inhibitors (HIF-PHIs) also known as hypoxia-inducible factor stabilizers (HIF stabilizers) are members of a mostly experimental class of drugs that act by inhibiting hypoxia-inducible factor-proline dioxygenase (HIF prolyl-hydroxylase) which is responsible to break down the hypoxia-inducible factor (HIF) under conditions of normal oxygen concentrations. As of 2008 they had been investigated in in cell models for the treatment of anemia, chronic kidney disease (CKD), ischemia including ischemia of the heart tissue, cancer, and others.Research conducted in mice suggests that they may increase hippocampal memory by increasing erythropoietin expression. As of 2021 research focuses mainly on anemia associated with CKD, and to some extent on ischemia. One drug of this class (roxadustat) is marketed in China and Japan for the treatment of anaemia in CKD patients. (en) HIF-PH阻害剤（HIF-PHそがいざい、低酸素誘導因子プロリン水酸化酵素阻害剤、hypoxia-inducible factor prolyl-hydroxylase inhibitor）は、低酸素誘導因子安定化剤（HIF安定化剤）としても知られ、低酸素誘導因子（HIF）の分解に関与するという酵素を阻害することによって作用する、新しい種類の薬剤である。 2008年現在、貧血や慢性腎臓病、がん 、心筋組織への影響などが研究されている。 マウスで行われた研究では、エリスロポエチンの発現を増加させることにより、海馬の記憶を増加させる可能性があることを示唆している。 (ja) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Roxadustat.svg?width=300 |
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22859273 (xsd:integer) |
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5544 (xsd:nonNegativeInteger) |
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1068588248 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Enarodustat dbr:Enzyme_inhibitor dbr:Hypoxia-inducible_factor dbr:Desidustat dbr:In_vitro dbr:Anemia dbr:Daprodustat dbr:Erythropoietin dbr:Chronic_kidney_disease dbr:Hippocampus dbc:Enzyme_inhibitors dbr:Ischemia dbr:Hypoxia-inducible_factor-proline_dioxygenase dbr:HIF_prolyl-hydroxylase dbr:Hypoxia-inducible_factors dbr:Factor_Inhibiting_HIF_Asparaginyl_Hydroxylase_Inhibitors dbr:Roxadustat dbr:Molidustat dbr:Vadadustat |
| dbp:atcPrefix |
B03X (en) |
| dbp:biologicalTarget |
dbr:HIF_prolyl-hydroxylase |
| dbp:caption |
Roxadustat, the first marketed HIF prolyl-hydroxylase inhibitor (en) |
| dbp:mechanismOfAction |
dbr:Enzyme_inhibitor |
| dbp:wikiPageUsesTemplate |
dbt:Infobox_drug_class dbt:As_of dbt:Reflist dbt:Unreliable_source? dbt:Blood-drug-stub |
| dct:subject |
dbc:Enzyme_inhibitors |
| gold:hypernym |
dbr:Members |
| rdf:type |
yago:Agent114778436 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:PhysicalEntity100001930 yago:Substance100020090 yago:WikicatDrugs |
| rdfs:comment |
HIF-PH阻害剤（HIF-PHそがいざい、低酸素誘導因子プロリン水酸化酵素阻害剤、hypoxia-inducible factor prolyl-hydroxylase inhibitor）は、低酸素誘導因子安定化剤（HIF安定化剤）としても知られ、低酸素誘導因子（HIF）の分解に関与するという酵素を阻害することによって作用する、新しい種類の薬剤である。 2008年現在、貧血や慢性腎臓病、がん 、心筋組織への影響などが研究されている。 マウスで行われた研究では、エリスロポエチンの発現を増加させることにより、海馬の記憶を増加させる可能性があることを示唆している。 (ja) Not to be confused with Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors Hypoxia-inducible factor prolyl hydroxylase Inhibitors (HIF-PHIs) also known as hypoxia-inducible factor stabilizers (HIF stabilizers) are members of a mostly experimental class of drugs that act by inhibiting hypoxia-inducible factor-proline dioxygenase (HIF prolyl-hydroxylase) which is responsible to break down the hypoxia-inducible factor (HIF) under conditions of normal oxygen concentrations. (en) |
| rdfs:label |
HIF prolyl-hydroxylase inhibitor (en) HIF-PH阻害剤 (ja) |
| owl:sameAs |
freebase:HIF prolyl-hydroxylase inhibitor yago-res:HIF prolyl-hydroxylase inhibitor wikidata:HIF prolyl-hydroxylase inhibitor dbpedia-ja:HIF prolyl-hydroxylase inhibitor https://global.dbpedia.org/id/4kGAr |
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wikipedia-en:HIF_prolyl-hydroxylase_inhibitor?oldid=1068588248&ns=0 |
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wiki-commons:Special:FilePath/Roxadustat.svg |
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wikipedia-en:HIF_prolyl-hydroxylase_inhibitor |
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dbr:HIF-PHI dbr:HIF_stabilizer dbr:Hypoxia-inducible_factor_prolyl_hydroxylase_Inhibitor dbr:Hypoxia-inducible_factor_stabilizer |
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dbr:Carlos_Oyarzun dbr:Enarodustat dbr:List_of_doping_cases_in_athletics dbr:List_of_doping_cases_in_cycling dbr:Procollagen-proline_dioxygenase dbr:Hypoxia-inducible_factor dbr:Bertrand_Moulinet dbr:Desidustat dbr:Daprodustat dbr:Fabio_Taborre dbr:Java–Partizan_Pro_Cycling_Team dbr:Hypoxia-inducible_factor-proline_dioxygenase dbr:HIF-PHI dbr:HIF_stabilizer dbr:Hypoxia-inducible_factor_prolyl_hydroxylase_Inhibitor dbr:Hypoxia-inducible_factor_stabilizer dbr:Factor_Inhibiting_HIF_Asparaginyl_Hydroxylase_Inhibitors dbr:Roxadustat dbr:Molidustat dbr:Vadadustat |
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wikipedia-en:HIF_prolyl-hydroxylase_inhibitor |
