Procollagen-proline dioxygenase (original) (raw)
Die Prolyl-4-Hydroxylase (4-PH) (auch: Procollagenprolin-Dioxygenase, EC 1.14.11.2) ist ein Enzymkomplex in Eukaryoten (Eucaryota), der in Gewebetieren oder Wirbeltieren die Hydroxylierung von Prolylresten in Proteinen katalysiert. Dabei handelt es sich um eine posttranslationale Modifikation. Sie ist essentiell für die Biosynthese des Kollagens.
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| dbo:abstract | Die Prolyl-4-Hydroxylase (4-PH) (auch: Procollagenprolin-Dioxygenase, EC 1.14.11.2) ist ein Enzymkomplex in Eukaryoten (Eucaryota), der in Gewebetieren oder Wirbeltieren die Hydroxylierung von Prolylresten in Proteinen katalysiert. Dabei handelt es sich um eine posttranslationale Modifikation. Sie ist essentiell für die Biosynthese des Kollagens. (de) La procollagène-proline dioxygénase, souvent appelée prolyle hydroxylase, est une oxydoréductase qui catalyse la réaction : L-proline du procollagène + α-oxoglutarate + O2 trans-4-hydroxy-L-proline du procollagène + succinate + CO2. Cette enzyme est une dioxygénase dépendant de l'α-oxoglutarate, qui catalysent l'incorporation d'oxygène dans des composés organiques à l'aide d'un mécanisme impliquant l'α-oxoglutarate, des cations de fer Fe2+ et du L-ascorbate ; cette enzyme-ci catalyse la formation d'hydroxyproline, qui est le résidu d'acide aminé résultant d'une modification post-traductionnelle le plus abondant du protéome humain. (fr) Procollagen-proline dioxygenase, commonly known as prolyl hydroxylase, is a member of the class of enzymes known as alpha-ketoglutarate-dependent hydroxylases. These enzymes catalyze the incorporation of oxygen into organic substrates through a mechanism that requires alpha-Ketoglutaric acid, Fe2+, and ascorbate. This particular enzyme catalyzes the formation of (2S, 4R)-4-hydroxyproline, a compound that represents the most prevalent post-translational modification in the human proteome. (en) La procollagene-prolina diossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: procollagene L-prolina + 2-ossoglutarato + O2 ⇄ procollagene trans-4-idrossi-L-prolina + succinato + CO2 L'enzima richiede Fe2+ e ascorbato. (it) プロコラーゲン-プロリンジオキシゲナーゼ（procollagen-proline 4-dioxygenase）は、次の化学反応を触媒する酸化還元酵素である。別名プロリルヒドロキシラーゼ、プロリン水酸化酵素とも。 プロコラーゲン-L-プロリン + 2-オキソグルタル酸 + O2 プロコラーゲン-trans-4-ヒドロキシ-L-プロリン + コハク酸 + CO2 反応式の通り、この酵素の基質はプロコラーゲン-L-プロリンと2-オキソグルタル酸とO2、生成物はプロコラーゲン-trans-4-ヒドロキシ-L-プロリンとコハク酸とCO2である。補因子として鉄とアスコルビン酸を用いる。 組織名はprocollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating)で、別名にprotocollagen hydroxylase、proline hydroxylase、proline,2-oxoglutarate 4-dioxygenase、collagen proline hydroxylase、hydroxylase, collagen proline、peptidyl proline hydroxylase、proline protocollagen hydroxylase、proline, 2-oxoglutarate dioxygenase、prolyl hydroxylase、prolylprotocollagen dioxygenase、prolylprotocollagen hydroxylase、protocollagen proline 4-hydroxylase、protocollagen proline dioxygenase、protocollagen proline hydroxylase、protocollagen prolyl hydroxylase、prolyl 4-hydroxylase、prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase,4-hydroxylatingprocollagen-proline 4-dioxygenaseがある。 (ja) |
| dbo:ecNumber | 1.14.11.2 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Alpha_subunits_of_prolyl_hydroxylase.png?width=300 |
| dbo:wikiPageExternalLink | http://www.expasy.org/prosite/PDOC51471 |
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| dbo:wikiPageWikiLink | dbr:Carbon_dioxide dbr:Prion dbr:Proline dbr:Elastin dbr:Elimination_reaction dbr:Nucleophilic_addition dbr:Blood_vessels dbr:Hydroxyproline dbr:Petechia dbr:C1Q_complex dbr:Decarboxylation dbr:Protein_disulfide-isomerase dbr:Proteome dbc:EC_1.14.11 dbc:Enzymes_of_known_structure dbc:Iron_enzymes dbr:Conotoxin dbr:Melting_point dbr:Enzyme dbr:Anemia dbr:Alpha-ketoglutaric_acid dbr:Ascorbic_acid dbr:Stroke dbr:Succinic_acid dbr:Post-translational_modification dbr:Active_site dbr:Tyrosine dbr:HIF_prolyl-hydroxylase_inhibitor dbr:Alpha-Ketoglutaric_acid dbr:Alpha-ketoglutarate-dependent_hydroxylases dbr:Oxygen dbr:PROSITE dbr:KDEL_(amino_acid_sequence) dbr:Purpura dbc:Ascorbate_enzymes dbr:Histidine dbr:Iron dbr:Ischemia dbr:Hydrolysis dbr:Argonaute dbr:Aspartic_acid dbc:Human_2OG_oxygenases dbr:Cofactor_(biochemistry) dbr:Collagen dbr:High-valent_iron dbr:HIF_prolyl-hydroxylase dbr:Hypoxia-inducible_factors dbr:Radical_(chemistry) dbr:Scurvy dbr:Tetrameric_protein dbr:File:Project_image_2.png |
| dbp:caption | Alpha subunits of procollagen-proline dioxygenase. Image shows substrate binding region and the binding groove of tyrosine residues (en) |
| dbp:casNumber | 9028-06-02 (xsd:date) |
| dbp:ecNumber | 1.140000 (xsd:double) |
| dbp:goCode | 4656 (xsd:integer) |
| dbp:iubmbEcNumber | 1 (xsd:integer) |
| dbp:name | Procollagen-proline dioxygenase (en) |
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| dcterms:subject | dbc:EC_1.14.11 dbc:Enzymes_of_known_structure dbc:Iron_enzymes dbc:Ascorbate_enzymes dbc:Human_2OG_oxygenases |
| gold:hypernym | dbr:Member |
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| rdfs:comment | Die Prolyl-4-Hydroxylase (4-PH) (auch: Procollagenprolin-Dioxygenase, EC 1.14.11.2) ist ein Enzymkomplex in Eukaryoten (Eucaryota), der in Gewebetieren oder Wirbeltieren die Hydroxylierung von Prolylresten in Proteinen katalysiert. Dabei handelt es sich um eine posttranslationale Modifikation. Sie ist essentiell für die Biosynthese des Kollagens. (de) Procollagen-proline dioxygenase, commonly known as prolyl hydroxylase, is a member of the class of enzymes known as alpha-ketoglutarate-dependent hydroxylases. These enzymes catalyze the incorporation of oxygen into organic substrates through a mechanism that requires alpha-Ketoglutaric acid, Fe2+, and ascorbate. This particular enzyme catalyzes the formation of (2S, 4R)-4-hydroxyproline, a compound that represents the most prevalent post-translational modification in the human proteome. (en) La procollagene-prolina diossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: procollagene L-prolina + 2-ossoglutarato + O2 ⇄ procollagene trans-4-idrossi-L-prolina + succinato + CO2 L'enzima richiede Fe2+ e ascorbato. (it) La procollagène-proline dioxygénase, souvent appelée prolyle hydroxylase, est une oxydoréductase qui catalyse la réaction : L-proline du procollagène + α-oxoglutarate + O2 trans-4-hydroxy-L-proline du procollagène + succinate + CO2. (fr) プロコラーゲン-プロリンジオキシゲナーゼ（procollagen-proline 4-dioxygenase）は、次の化学反応を触媒する酸化還元酵素である。別名プロリルヒドロキシラーゼ、プロリン水酸化酵素とも。 プロコラーゲン-L-プロリン + 2-オキソグルタル酸 + O2 プロコラーゲン-trans-4-ヒドロキシ-L-プロリン + コハク酸 + CO2 反応式の通り、この酵素の基質はプロコラーゲン-L-プロリンと2-オキソグルタル酸とO2、生成物はプロコラーゲン-trans-4-ヒドロキシ-L-プロリンとコハク酸とCO2である。補因子として鉄とアスコルビン酸を用いる。 (ja) |
| rdfs:label | Prolyl-4-Hydroxylase (de) Procollagene-prolina diossigenasi (it) Procollagène-proline dioxygénase (fr) プロコラーゲン-プロリンジオキシゲナーゼ (ja) Procollagen-proline dioxygenase (en) |
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| foaf:name | Procollagen-proline dioxygenase (en) |
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