| dbo:abstract |
HLA-B46 هو نمط مصلي من مستضد الكريات البيضاء البشرية-ب. (ar) HLA-B46 (B46) is an HLA-B serotype. The serotype identifies the gene products of HLA-B*4601 allele.B*4601 resulted from a rare, interlocus, gene conversion between B62, probably B*1501, and a HLA-C allele. B*4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele. When found B*4601 segregates with only 2 HLA-Cw alleles, A limited number of HLA-A and HLA-DRB1 alleles suggesting that the allele recently expanded from a limited sized group within SE Asia. Extremely low frequencies outside of Eastern Asia are indicators of a recent expansion of B46 from a recently small population. The frequency distribution suggests the ancestral B46 population was in SE China, or, potentially Burma (Myanmar or Laos, untested). B46 in Asia correlates with wet-rice farming. The exceptions are notable, it has been found in the Nivkhi on north-eastern Sakalin Island, the Ainu, and the Nivkhi-related (genetically) Tlinglet population of Alaska at trace levels. (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/B46_Frequencies.png?width=300 |
| dbo:wikiPageExternalLink |
https://web.archive.org/web/20070821210135/http:/www.gene.ucl.ac.uk/nomenclature/data/get_data.php%3Fhgnc_id=4932 http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi%3FB*4601 https://www.ncbi.nlm.nih.gov/Omim/getmap.cgi%3Fchromosome=6p21.31 |
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| dbo:wikiPageWikiLink |
dbr:Qinghai dbr:Buyei dbr:Hokkaidō dbr:Hong_Kong dbr:Hui_people dbr:Ulaanbaatar dbr:Polymerase_chain_reaction dbc:HLA-B_alleles dbr:Gene_conversion dbr:Gene_product dbr:Naxi_people dbr:Mongolia dbr:Linqu_County dbr:Yunnan dbr:Paddy_field dbr:HLA-A dbr:HLA-B dbr:HLA-B15 dbr:HLA-B18 dbr:HLA-B48 dbr:HLA-B55 dbr:HLA-B62 dbr:HLA-B73 dbr:HLA-C dbr:Locus_(genetics) dbr:Aichi dbr:Ainu_people dbr:European_Bioinformatics_Institute dbr:Guangxi dbr:Guangzhou dbr:Hakka_people dbr:Japan dbr:Java dbr:Thai_people dbr:China dbr:Maonan_people dbr:Southern_Min dbr:Human_Genome_Organisation dbr:Human_leukocyte_antigen dbr:HLA-DRB1 dbr:Miao_people dbr:Shandong dbr:Wuhan dbr:Serotype dbr:Chromosome_6_(human) dbr:Khalkh dbr:File:B46_Frequencies.PNG |
| dbp:wikiPageUsesTemplate |
dbt:Clear dbt:Reflist dbt:Technical dbt:Use_dmy_dates dbt:HLA-B_serotypes |
| dct:subject |
dbc:HLA-B_alleles |
| gold:hypernym |
dbr:Serotype |
| rdf:type |
dbo:Species yago:Abstraction100002137 yago:Allele105437785 yago:Arrangement107938773 yago:Gene105436752 yago:Group100031264 yago:Ordering108456993 yago:WikicatHLA-BAlleles yago:Sequence108459252 yago:Series108457976 |
| rdfs:comment |
HLA-B46 هو نمط مصلي من مستضد الكريات البيضاء البشرية-ب. (ar) HLA-B46 (B46) is an HLA-B serotype. The serotype identifies the gene products of HLA-B*4601 allele.B*4601 resulted from a rare, interlocus, gene conversion between B62, probably B*1501, and a HLA-C allele. B*4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele. When found B*4601 segregates with only 2 HLA-Cw alleles, A limited number of HLA-A and HLA-DRB1 alleles suggesting that the allele recently expanded from a limited sized group within SE Asia. Extremely low frequencies outside of Eastern Asia are indicators of a recent expansion of B46 from a recently small population. The frequency distribution suggests the ancestral B46 population was in SE China, or, potentially Burma (Myanmar or Laos, (en) |
| rdfs:label |
HLA-B46 (ar) HLA-B46 (en) |
| owl:sameAs |
freebase:HLA-B46 yago-res:HLA-B46 wikidata:HLA-B46 dbpedia-ar:HLA-B46 https://global.dbpedia.org/id/4kMRo |
| prov:wasDerivedFrom |
wikipedia-en:HLA-B46?oldid=1123481885&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/B46_Frequencies.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:HLA-B46 |
| is dbo:wikiPageWikiLink of |
dbr:B46 dbr:HLA-B dbr:HLA-B15 dbr:HLA-B18 dbr:HLA-B55 dbr:HLA-B73 dbr:HLA-A*02 |
| is foaf:primaryTopic of |
wikipedia-en:HLA-B46 |
