HLA-B (original) (raw)
Con la dicitura HLA-B viene gergalmente indicato il gene responsabile della resistenza al virus dell'AIDS (Sindrome da Immunodeficienza Acquisita), più correttamente indicato con il nome major histocompatibility complex, class I, B. Esso rappresenta una particolare variante umana di proteine appartenenti al complesso maggiore di istocompatibilità, la quale riconosce gli antigeni virali estranei all'organismo, identificando come estraneo ciò che non appartiene all'organismo umano. HLA-B fa parte di una famiglia di geni denominati: human leukocyte antigen complex (HLA).
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| dbo:abstract | معقد التوافق النسيجي الكبير-ب (بالإنجليزية: Major histocompatibility complex, class I, B) أو مستضد الكريات البيضاء البشرية-ب ومختصره (HLA-B) هو مورثة موجودة عن الإنسان لها دور في الجهاز المناعي. يمثل مستضد الكريات البيضاء البشرية النسخة البشرية من معقد التوافق النسيجي الكبير (MHC)، وهي مجموعة من المورثات الموجودة في أنواع مختلفة. هذا المجموعة من المورثات تقسم إلى 3 أصناف هي: * * * أما عند الإنسان، فمعقد التوافق النسيجي الكبير-ب ومورثتين آخريين هما (مستضد الكريات البيضاء البشرية-أ) هي مورثات رئيسية ضمن معقد التوافق النسيجي الكبير، الصنف الأول. يوجد على معقد التوافق النسيجي الكبير-ب الكروموسوم 6. (ar) HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. HLA is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. Genes in this complex are separated into three basic groups: class I, class II, and class III. In humans, the HLA-B gene and two related genes, HLA-A and HLA-C, are the major genes in MHC class I. MHC class I genes provide instructions for making proteins that are present on the surface of almost all cells. On the cell surface, these proteins are bound to protein fragments (peptides) that have been exported from within the cell. MHC class I proteins display these peptides to the immune system. If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it responds by destroying the infected cell. The HLA-B gene has many different normal variations, allowing each person's immune system to react to a wide range of foreign invaders. Hundreds of versions (alleles) of HLA-B are known, each of which is given a particular number (such as HLA-B27). Closely related alleles are categorized together; for example, at least 28 very similar alleles are subtypes of HLA-B27. These subtypes are designated as HLA-B*2701 to HLA-B*2728. The HLA-B gene is located on the short (p) arm of chromosome 6 at cytoband 21.3, from base pair 31,353,871 to 31,357,211 (en) Con la dicitura HLA-B viene gergalmente indicato il gene responsabile della resistenza al virus dell'AIDS (Sindrome da Immunodeficienza Acquisita), più correttamente indicato con il nome major histocompatibility complex, class I, B. Esso rappresenta una particolare variante umana di proteine appartenenti al complesso maggiore di istocompatibilità, la quale riconosce gli antigeni virali estranei all'organismo, identificando come estraneo ciò che non appartiene all'organismo umano. HLA-B fa parte di una famiglia di geni denominati: human leukocyte antigen complex (HLA). (it) HLA-B (англ. HLA class I histocompatibility antigen, B-7 alpha chain) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 362 амінокислот, а молекулярна маса — 40 460. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у таких біологічних процесах, як імунітет, взаємодія хазяїн-вірус. Локалізований у мембрані. (uk) HLA-B是人類白細胞抗原（HLA）的一个基因座位于6号染色体上。 (zh) |
| dbo:wikiPageExternalLink | http://ghr.nlm.nih.gov https://web.archive.org/web/20041210030749/http:/www.anthonynolan.org.uk/HIG/lists/nomenc.html https://web.archive.org/web/20060508235645/http:/www.pubmedcentral.gov/articlerender.fcgi%3Ftool=pubmed https://web.archive.org/web/20071126140820/http:/www.pnas.org/cgi/content/full/97/6/2709 https://nsuworks.nova.edu/cnso_bio_facarticles/794 http://www.annals.org/cgi/reprint/136/12/896 http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2010.02533.x/pdf https://zenodo.org/record/1235017 http://www.pnas.org/cgi/content/full/97/6/2709 |
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| dbp:date | 2007-11-26 (xsd:date) |
| dbp:url | https://web.archive.org/web/20071126140820/http:/www.pnas.org/cgi/content/full/97/6/2709 |
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| rdfs:comment | Con la dicitura HLA-B viene gergalmente indicato il gene responsabile della resistenza al virus dell'AIDS (Sindrome da Immunodeficienza Acquisita), più correttamente indicato con il nome major histocompatibility complex, class I, B. Esso rappresenta una particolare variante umana di proteine appartenenti al complesso maggiore di istocompatibilità, la quale riconosce gli antigeni virali estranei all'organismo, identificando come estraneo ciò che non appartiene all'organismo umano. HLA-B fa parte di una famiglia di geni denominati: human leukocyte antigen complex (HLA). (it) HLA-B是人類白細胞抗原（HLA）的一个基因座位于6号染色体上。 (zh) معقد التوافق النسيجي الكبير-ب (بالإنجليزية: Major histocompatibility complex, class I, B) أو مستضد الكريات البيضاء البشرية-ب ومختصره (HLA-B) هو مورثة موجودة عن الإنسان لها دور في الجهاز المناعي. يمثل مستضد الكريات البيضاء البشرية النسخة البشرية من معقد التوافق النسيجي الكبير (MHC)، وهي مجموعة من المورثات الموجودة في أنواع مختلفة. هذا المجموعة من المورثات تقسم إلى 3 أصناف هي: * * * أما عند الإنسان، فمعقد التوافق النسيجي الكبير-ب ومورثتين آخريين هما (مستضد الكريات البيضاء البشرية-أ) هي مورثات رئيسية ضمن معقد التوافق النسيجي الكبير، الصنف الأول. (ar) HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. The HLA-B gene is located on the short (p) arm of chromosome 6 at cytoband 21.3, from base pair 31,353,871 to 31,357,211 (en) HLA-B (англ. HLA class I histocompatibility antigen, B-7 alpha chain) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 362 амінокислот, а молекулярна маса — 40 460. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | مستضد الكريات البيضاء البشرية-ب (ar) HLA-B (en) HLA-B (it) HLA-B (zh) HLA-B (uk) |
| owl:sameAs | freebase:HLA-B wikidata:HLA-B dbpedia-ar:HLA-B http://arz.dbpedia.org/resource/معقد_التوافق_النسيجى_الكبير_ب dbpedia-cy:HLA-B dbpedia-gl:HLA-B dbpedia-it:HLA-B http://www4.wiwiss.fu-berlin.de/diseasome/resource/genes/HLA-B yago-res:HLA-B dbpedia-uk:HLA-B dbpedia-zh:HLA-B https://global.dbpedia.org/id/jcEs |
| prov:wasDerivedFrom | wikipedia-en:HLA-B?oldid=1122307909&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:HLA-B |
| is dbo:wikiPageRedirects of | dbr:HLA-B_(gene) dbr:HLA-B*5701 dbr:Hla-b_antigens |
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| is dbp:gene2name of | dbr:HLA_B7-DR15-DQ6 |
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