| dbo:abstract |
Infected cell protein 34.5 (ICP-34.5, ICP34.5, or GADD34) is a protein expressed by the ɣ34.5 gene in viruses such as herpes simplex virus; it blocks a cellular stress response to viral infection. It shares the C-terminal regulatory domain (InterPro: IPR019523) with protein phosphatase 1 subunit 15A/. When a cell is infected with a virus, protein kinase R is activated by the virus' double-stranded RNA,. Protein kinase R then phosphorylates a protein called eukaryotic initiation factor-2A (eIF-2A), which inactivates eIF-2A. EIF-2A is required for translation so by shutting down eIF-2A, the cell prevents the virus from hijacking its own protein-making machinery. Viruses in turn evolved ICP34.5 to defeat the defense; it activates protein phosphatase-1A which dephosphorylates eIF-2A, allowing translation to occur again. A herpesvirus lacking the ɣ34.5 gene will not be able to replicate in normal cells because it cannot make proteins. The ICP34.5 deletion is useful for the construction of Oncolytic herpes viruses, as cancer cells do not restrict replication as strongly. (en) |
| dbo:wikiPageID |
52007407 (xsd:integer) |
| dbo:wikiPageLength |
2346 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
996335469 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Protein_phosphatase_1 dbr:Oncolytic_herpes_virus dbr:EIF2 dbr:Protein_kinase_R dbc:Viral_nonstructural_proteins dbr:Cellular_stress_response dbr:Herpes_simplex_virus dbr:Translation_(biology) dbr:PPP1R15A dbr:Viral_nonstructural_protein dbr:Phosphorylation dbr:Double-stranded_RNA dbr:PPP1R15B |
| dbp:name |
Neurovirulence factor ICP34.5 (en) |
| dbp:organism |
Human alphaherpesvirus 1 strain 17 (en) |
| dbp:symbol |
ICP34.5 (en) |
| dbp:uniprot |
P36313 (en) |
| dbp:wikiPageUsesTemplate |
dbt:Virus-stub dbt:Infobox_nonhuman_protein dbt:Reflist dbt:InterPro dbt:Viral_proteins |
| dcterms:subject |
dbc:Viral_nonstructural_proteins |
| rdfs:comment |
Infected cell protein 34.5 (ICP-34.5, ICP34.5, or GADD34) is a protein expressed by the ɣ34.5 gene in viruses such as herpes simplex virus; it blocks a cellular stress response to viral infection. It shares the C-terminal regulatory domain (InterPro: IPR019523) with protein phosphatase 1 subunit 15A/. The ICP34.5 deletion is useful for the construction of Oncolytic herpes viruses, as cancer cells do not restrict replication as strongly. (en) |
| rdfs:label |
Infected cell protein 34.5 (en) |
| owl:sameAs |
wikidata:Infected cell protein 34.5 https://global.dbpedia.org/id/2bzLt yago-res:Infected cell protein 34.5 |
| prov:wasDerivedFrom |
wikipedia-en:Infected_cell_protein_34.5?oldid=996335469&ns=0 |
| foaf:isPrimaryTopicOf |
wikipedia-en:Infected_cell_protein_34.5 |
| is dbo:wikiPageRedirects of |
dbr:ICP34.5 |
| is dbo:wikiPageWikiLink of |
dbr:Protein_phosphatase_1 dbr:Talimogene_laherparepvec dbr:ICP34.5 |
| is foaf:primaryTopic of |
wikipedia-en:Infected_cell_protein_34.5 |