| dbo:abstract |
La ibogamina es un alcaloide que se encuentra en Tabernanthe iboga. La investigación básica relacionada con cómo la adicción afecta el cerebro ha utilizado esta sustancia química. La ibogamina redujo la autoadministración de cocaína y la morfina en ratas, siendo más consistente que otros alcaloides iboga, incluso la ibogaína. (es) Ibogamine is an anti-convulsant, anti-addictive, CNS stimulant alkaloid found in Tabernanthe iboga and Crepe Jasmine (Tabernaemontana divaricata). Basic research related to how addiction affects the brain has used this chemical. Ibogamine persistently reduced the self-administration of cocaine and morphine in rats. The same study found that ibogamine (40 mg/kg) and coronaridine (40 mg/kg) did not produce "any tremor effects in rats that differ significantly from saline control". While the related alkaloids ibogaine (20–40 mg/kg), harmaline (10–40 mg/kg) and (10–40 mg/kg) were "obviously tremorgenic". (en) イボガミン(Ibogamine)は、イボガ(Tabernanthe iboga)に含まれるアルカロイドである。 薬物依存症がどのように脳に影響を与えるかの基礎研究は、この物質を用いて行われた。 イボガミンは、イボガイン等の他のイボガアルカロイドと比べ、ラットにおいてコカインやモルヒネの自己投与をより一貫して減少させた。 (ja) |
| dbo:casNumber |
481-87-8 |
| dbo:chEBI |
5853 |
| dbo:pubchem |
100217 |
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wiki-commons:Special:FilePath/Ibogamine.svg?width=300 |
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dbr:Alkaloid dbr:Voacangine dbr:Tabernaemontana_divaricata dbc:NMDA_receptor_antagonists dbr:Coronaridine dbc:Alkaloids_found_in_Iboga dbc:Tryptamine_alkaloids dbr:Anti-addictive dbr:Substance_dependence dbr:Tremor dbc:Oneirogens dbr:Basic_research dbr:Tabernanthe_iboga dbr:Harmaline dbr:Ibogaine dbr:Ibogaline dbr:Nicotinic_acetylcholine_receptor dbr:Κ-opioid_receptor dbr:NMDA_receptor dbr:Tabernanthine dbr:Anti-convulsant dbr:Desethylcoronaridine |
| dbp:alt |
Ball-and-stick model of the ibogamine molecule (en) Skeletal formula of ibogamine (en) |
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none (en) |
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Ibogamine_molecule_ball.png (en) |
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CC[C@H]1C[C@@H]2C[C@@H]3[C@H]1NCCC4=C3NC5=CC=CC=C45 (en) |
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LRLCVRYKAFDXKU-YGOSVGOTSA-N (en) |
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| dcterms:subject |
dbc:NMDA_receptor_antagonists dbc:Alkaloids_found_in_Iboga dbc:Tryptamine_alkaloids dbc:Oneirogens |
| gold:hypernym |
dbr:Alkaloid |
| rdf:type |
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| rdfs:comment |
La ibogamina es un alcaloide que se encuentra en Tabernanthe iboga. La investigación básica relacionada con cómo la adicción afecta el cerebro ha utilizado esta sustancia química. La ibogamina redujo la autoadministración de cocaína y la morfina en ratas, siendo más consistente que otros alcaloides iboga, incluso la ibogaína. (es) イボガミン(Ibogamine)は、イボガ(Tabernanthe iboga)に含まれるアルカロイドである。 薬物依存症がどのように脳に影響を与えるかの基礎研究は、この物質を用いて行われた。 イボガミンは、イボガイン等の他のイボガアルカロイドと比べ、ラットにおいてコカインやモルヒネの自己投与をより一貫して減少させた。 (ja) Ibogamine is an anti-convulsant, anti-addictive, CNS stimulant alkaloid found in Tabernanthe iboga and Crepe Jasmine (Tabernaemontana divaricata). Basic research related to how addiction affects the brain has used this chemical. (en) |
| rdfs:label |
Ibogamina (es) Ibogamine (en) イボガミン (ja) |
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wikipedia-en:Ibogamine?oldid=1112567238&ns=0 |
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wiki-commons:Special:FilePath/Ibogamine.svg wiki-commons:Special:FilePath/Ibogamine_molecule_ball.png |
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dbr:Oneirogen dbr:Alkaloid dbr:Indole_alkaloid dbr:List_of_psychoactive_plants,_fungi,_and_animals dbr:Tabernaemontana_divaricata dbr:19,20-Dihydroervahanine_A dbr:Conophylline dbr:Coronaridine dbr:Iboga_alkaloid dbr:Dregamine dbr:Bark_isolate dbr:Noribogaine dbr:Tabernanthe_iboga dbr:Harmaline dbr:Tabernaemontanine dbr:C19H24N2 dbr:Ibogaine dbr:Ibogaline dbr:Indatraline dbr:Tabernanthine |
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wikipedia-en:Ibogamine |
