Indole 2,3-dioxygenase (original) (raw)
La indolo 2,3-diossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: indolo + O2 ⇄ 2-formilamminobenzaldeide L'enzima della pianta Jasminum grandiflorum è una flavoproteina contenente rame, e forma antranilato come prodotto finale. Anche uno degli enzimi di Tecoma stans è una flavoproteina contenente rame ed usa tre moli di ossigeno per mole di indolo, per formare (3,4-benzoisossiazolo). Un secondo enzima di , che non è una flavoproteina, usa quattro moli di ossigeno e forma antranilato come prodotto finale.
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| dbo:abstract | In enzymology, an indole 2,3-dioxygenase (EC 1.13.11.17) is an enzyme that catalyzes the chemical reaction indole + O2 2-formylaminobenzaldehyde Thus, the two substrates of this enzyme are indole and O2, whereas its product is . This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is indole:oxygen 2,3-oxidoreductase (decyclizing). Other names in common use include indole oxidase, indoleamine 2,3-dioxygenase (ambiguous), indole:O2 oxidoreductase, indole-oxygen 2,3-oxidoreductase (decyclizing), and IDO (ambiguous). This enzyme participates in tryptophan metabolism. It has 3 cofactors: copper, Flavin, and Flavoprotein. Indole dioxygenase is not specific to indole but rather operates on a broad range of indole derivatives, including the amino acids tryptophan and 5-hydroxytryptophan (5-HTP), and many indole-analog plant phytochemicals. IDO is a peripheral enzyme, in contrast to tryptophan oxidase, an enzyme of similar amino acid sequence, which is active only in the liver. IDO is induced (produced on demand) by activation of inflammatory processes involving cytokine expression by white blood cells. (en) La indolo 2,3-diossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: indolo + O2 ⇄ 2-formilamminobenzaldeide L'enzima della pianta Jasminum grandiflorum è una flavoproteina contenente rame, e forma antranilato come prodotto finale. Anche uno degli enzimi di Tecoma stans è una flavoproteina contenente rame ed usa tre moli di ossigeno per mole di indolo, per formare (3,4-benzoisossiazolo). Un secondo enzima di , che non è una flavoproteina, usa quattro moli di ossigeno e forma antranilato come prodotto finale. (it) インドール-2,3-ジオキシゲナーゼ（indole 2,3-dioxygenase）は、トリプトファン代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 インドール + O2 2-ホルミルアミノベンズアルデヒド 反応式の通り、この酵素の基質はインドールとO2、生成物はである。補因子として銅、フラビン、フラボタンパク質を用いる。 組織名はindole:oxygen 2,3-oxidoreductase (decyclizing)で、別名にindole oxidase、indoleamine 2,3-dioxygenase (ambiguous)、indole:O2 oxidoreductase、indole-oxygen 2,3-oxidoreductase (decyclizing)、IDO (ambiguous)がある。 (ja) |
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| dbp:name | indole 2,3-dioxygenase (en) |
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| rdfs:comment | La indolo 2,3-diossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: indolo + O2 ⇄ 2-formilamminobenzaldeide L'enzima della pianta Jasminum grandiflorum è una flavoproteina contenente rame, e forma antranilato come prodotto finale. Anche uno degli enzimi di Tecoma stans è una flavoproteina contenente rame ed usa tre moli di ossigeno per mole di indolo, per formare (3,4-benzoisossiazolo). Un secondo enzima di , che non è una flavoproteina, usa quattro moli di ossigeno e forma antranilato come prodotto finale. (it) インドール-2,3-ジオキシゲナーゼ（indole 2,3-dioxygenase）は、トリプトファン代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 インドール + O2 2-ホルミルアミノベンズアルデヒド 反応式の通り、この酵素の基質はインドールとO2、生成物はである。補因子として銅、フラビン、フラボタンパク質を用いる。 組織名はindole:oxygen 2,3-oxidoreductase (decyclizing)で、別名にindole oxidase、indoleamine 2,3-dioxygenase (ambiguous)、indole:O2 oxidoreductase、indole-oxygen 2,3-oxidoreductase (decyclizing)、IDO (ambiguous)がある。 (ja) In enzymology, an indole 2,3-dioxygenase (EC 1.13.11.17) is an enzyme that catalyzes the chemical reaction indole + O2 2-formylaminobenzaldehyde Thus, the two substrates of this enzyme are indole and O2, whereas its product is . (en) |
| rdfs:label | Indole 2,3-dioxygenase (en) Indolo 2,3-diossigenasi (it) インドール-2,3-ジオキシゲナーゼ (ja) |
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| foaf:name | indole 2,3-dioxygenase (en) |
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