Tumor microenvironment (original) (raw)
Als Tumormikroumgebung, auch Tumormikromilieu (englisch tumor microenvironment) genannt, bezeichnet man in der Onkologie das unmittelbare Umfeld eines bösartigen Tumors in einem Organismus. Die Tumormikroumgebung hat einen entscheidenden Einfluss auf die Karzinogenese (Tumorentwicklung).
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| dbo:abstract | Nádorové mikroprostředí zahrnuje všechny buněčné i nebuněčné složky, které jsou součástí nádorové tkáně a zároveň i interakce mezi nádorovými buňkami a zdravými tkáněmi přímo v nádoru či jeho blízkém okolí. V naprosté většině nádorů se kromě samotných transformovaných buněk nachází i krevní a lymfatické cévy, leukocyty, fibroblasty, cytokiny a další signální molekuly či složky extracelulární matrix. Navíc je prostředí nádoru specifické i svými fyzikálně-chemickými vlastnosti jako je pH či parciální tlak kyslíku. Všechny tyto složky tvoří nádorové mikroprostředí a ovlivňují progresi nádoru. Na rozdíl od dalších termínu označujících součásti nádoru (nádorový parenchym, nádorové stroma aj.), se výrazem nádorové mikroprostředí zdůrazňuje zejména dynamika a reciprocita funkčních vztahů mezi jednotlivými složkami. (cs) Als Tumormikroumgebung, auch Tumormikromilieu (englisch tumor microenvironment) genannt, bezeichnet man in der Onkologie das unmittelbare Umfeld eines bösartigen Tumors in einem Organismus. Die Tumormikroumgebung hat einen entscheidenden Einfluss auf die Karzinogenese (Tumorentwicklung). (de) Le microenvironnement tumoral (TME, pour tumor microenvironment) est l'environnement autour des cellules tumorales qui comprend des vaisseaux sanguins des cellules immunitaires, des fibroblastes, des molécules de signalisation et la matrice extracellulaire (MEC). Les tumeurs se définissent par la somme d'un microenvironnement tumoral et de cellules tumorales. Les cellules tumorales et le microenvironnement tumoral sont étroitement liés et interagissent en permanence. Les cellules tumorales peuvent influencer le microenvironnement en libérant des signaux extracellulaires, en favorisant l'angiogenèse tumorale et en induisant une tolérance immunitaire périphérique, tandis que les cellules immunitaires du microenvironnement tumoral peuvent affecter la croissance et l'évolution des cellules cancéreuses. (fr) The tumor microenvironment (TME) is the environment around a tumor, including the surrounding blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix (ECM). The tumor and the surrounding microenvironment are closely related and interact constantly. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells. (en) Il microambiente del tumore (denominato nella letteratura scientifica internazionale tumor microenvironment o TME) è l'ambiente cellulare ed extracellulare attorno al quale esiste e si sviluppa il tumore. Nel caso di tumori solidi non è raro riferirsi al microambiente con il termine di "stroma del tumore". Esso comprende: * i vasi sanguigni circostanti (formati parzialmente dalle cellule endoteliali associate al tumore); * cellule del sistema immunitario (sia della linea mieloide che linfoide) che possono eventualmente infiltrare il tumore (es: linfociti infiltranti il tumore) condizionandone la crescita e l'evoluzione; * cellule connettivali (es. fibroblasti associati al tumore); * matrice extracellulare del tumore (ECM), che può contenere e concentrare fattori di crescita o nano-farmaci grazie all'. Il microambiente tumorale e il tumore sono intimamente correlati si influenzano reciprocamente; ad esempio: * i tumori possono influenzare il microambiente rilasciando mitogeni (promuovendo a valle l'angiogenesi) o inducendo immunoresistenza alla periferia del tumore; * il microambiente può influenzare il tumore (es. grazie alle sue cellule immunitarie che possono distruggerlo o prevenirne un'ulteriore crescita). Il microambiente del tumore contribuisce all'. (it) 肿瘤微环境（英語：Tumor microenvironment）是指肿瘤细胞存在的周围微环境，包括周围的血管、免疫细胞、成纤维细胞、骨髓源性炎性细胞、各种信号分子和细胞外基质（ECM）。 肿瘤和周围环境密切相关，不断进行交互作用，肿瘤可以通过释放细胞信号分子影响其微环境环境，促进肿瘤的血管生成和诱导免疫耐受，而微环境中的免疫细胞可影响癌细胞增长和发育。腫瘤微環境中常見的免疫細胞特性包含以下三者：(1)具細胞毒殺功能的自然殺手細胞、細胞毒性T細胞數量減少；(2)具免疫抑制功能的骨髓來源的抑制性細胞(Myeloid-derived suppressor cell, MDSC)及調節T細胞數量增加；(3)巨噬細胞及嗜中性球分別由具促發炎能力的M1及N1表型，轉變為具抑制免疫反應而能促進腫瘤生長的M2及N2表型 肿瘤微环境有助于的形成。 (zh) |
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| rdfs:comment | Als Tumormikroumgebung, auch Tumormikromilieu (englisch tumor microenvironment) genannt, bezeichnet man in der Onkologie das unmittelbare Umfeld eines bösartigen Tumors in einem Organismus. Die Tumormikroumgebung hat einen entscheidenden Einfluss auf die Karzinogenese (Tumorentwicklung). (de) The tumor microenvironment (TME) is the environment around a tumor, including the surrounding blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix (ECM). The tumor and the surrounding microenvironment are closely related and interact constantly. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells. (en) 肿瘤微环境（英語：Tumor microenvironment）是指肿瘤细胞存在的周围微环境，包括周围的血管、免疫细胞、成纤维细胞、骨髓源性炎性细胞、各种信号分子和细胞外基质（ECM）。 肿瘤和周围环境密切相关，不断进行交互作用，肿瘤可以通过释放细胞信号分子影响其微环境环境，促进肿瘤的血管生成和诱导免疫耐受，而微环境中的免疫细胞可影响癌细胞增长和发育。腫瘤微環境中常見的免疫細胞特性包含以下三者：(1)具細胞毒殺功能的自然殺手細胞、細胞毒性T細胞數量減少；(2)具免疫抑制功能的骨髓來源的抑制性細胞(Myeloid-derived suppressor cell, MDSC)及調節T細胞數量增加；(3)巨噬細胞及嗜中性球分別由具促發炎能力的M1及N1表型，轉變為具抑制免疫反應而能促進腫瘤生長的M2及N2表型 肿瘤微环境有助于的形成。 (zh) Nádorové mikroprostředí zahrnuje všechny buněčné i nebuněčné složky, které jsou součástí nádorové tkáně a zároveň i interakce mezi nádorovými buňkami a zdravými tkáněmi přímo v nádoru či jeho blízkém okolí. V naprosté většině nádorů se kromě samotných transformovaných buněk nachází i krevní a lymfatické cévy, leukocyty, fibroblasty, cytokiny a další signální molekuly či složky extracelulární matrix. Navíc je prostředí nádoru specifické i svými fyzikálně-chemickými vlastnosti jako je pH či parciální tlak kyslíku. Všechny tyto složky tvoří nádorové mikroprostředí a ovlivňují progresi nádoru. Na rozdíl od dalších termínu označujících součásti nádoru (nádorový parenchym, nádorové stroma aj.), se výrazem nádorové mikroprostředí zdůrazňuje zejména dynamika a reciprocita funkčních vztahů mezi jed (cs) Le microenvironnement tumoral (TME, pour tumor microenvironment) est l'environnement autour des cellules tumorales qui comprend des vaisseaux sanguins des cellules immunitaires, des fibroblastes, des molécules de signalisation et la matrice extracellulaire (MEC). Les tumeurs se définissent par la somme d'un microenvironnement tumoral et de cellules tumorales. (fr) Il microambiente del tumore (denominato nella letteratura scientifica internazionale tumor microenvironment o TME) è l'ambiente cellulare ed extracellulare attorno al quale esiste e si sviluppa il tumore. Nel caso di tumori solidi non è raro riferirsi al microambiente con il termine di "stroma del tumore". Esso comprende: Il microambiente tumorale e il tumore sono intimamente correlati si influenzano reciprocamente; ad esempio: Il microambiente del tumore contribuisce all'. (it) |
| rdfs:label | Nádorové mikroprostředí (cs) Tumormikroumgebung (de) Microambiente del tumore (it) Micro-environnement tumoral (fr) Tumor microenvironment (en) 肿瘤微环境 (zh) |
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