| dbo:abstract |
In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events. The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. In addition, ICAMs may exist in soluble forms in human plasma, due to activation and proteolysis mechanisms at cell surfaces. Mammalian intercellular adhesion molecules include: * ICAM-1 * ICAM2 * ICAM3 * ICAM4 * ICAM5 (en) 在分子生物学中，细胞间黏附分子（英語：intercellular adhesion molecule，ICAM）和血管细胞黏附分子-1（VCAM-1）是的一部分，在炎症、免疫反应和细胞内信号传导事件中有重要作用。ICAM家族由五个成员组成，命名为ICAM-1至ICAM-5。已知它们在炎症和免疫应答期间与白细胞整合素CD11/CD18如LFA-1和结合。另外，由于细胞表面的激活和蛋白水解机制，ICAM可能以可溶形式存在于人血浆中。 哺乳动物的细胞间黏附分子包括： * * * * * (zh) |
| dbo:symbol |
ICAM_N |
| dbo:thumbnail |
wiki-commons:Special:FilePath/PDB_1iam_EBI.jpg?width=300 |
| dbo:wikiPageID |
1537176 (xsd:integer) |
| dbo:wikiPageLength |
1816 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
993155916 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Blood_plasma dbr:Homo_sapiens dbr:CD18 dbr:Inflammation dbc:Cell_biology dbc:Protein_families dbr:ICAM-1 dbr:Proteolysis dbr:Macrophage-1_antigen dbr:Cell_(biology) dbr:Intracellular dbr:CD11 dbr:ICAM5 dbr:Cell_signalling dbr:ICAM2 dbr:ICAM3 dbr:ICAM4 dbr:Immune_response dbr:Immunoglobulin_superfamily dbr:Molecular_biology dbr:Integrins dbr:LFA-1 dbr:Vascular_cell_adhesion_molecule-1 dbr:Leucocyte |
| dbp:caption |
structure of the two amino-terminal domains of human intercellular adhesion molecule-1, icam-1 (en) |
| dbp:interpro |
IPR013768 (en) |
| dbp:membranomeFamily |
219 (xsd:integer) |
| dbp:name |
Intercellular adhesion molecule , N-terminal domain (en) |
| dbp:pfam |
PF03921 (en) |
| dbp:pfamClan |
CL0011 (en) |
| dbp:scop |
1 (xsd:integer) |
| dbp:symbol |
ICAM_N (en) |
| dbp:wikiPageUsesTemplate |
dbt:Biochem-stub dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist dbt:Cell_adhesion_molecules |
| dct:subject |
dbc:Cell_biology dbc:Protein_families |
| gold:hypernym |
dbr:Part |
| rdf:type |
owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity dbo:Protein yago:SocialGroup107950920 yago:Unit108189659 yago:WikicatProteinFamilies |
| rdfs:comment |
在分子生物学中，细胞间黏附分子（英語：intercellular adhesion molecule，ICAM）和血管细胞黏附分子-1（VCAM-1）是的一部分，在炎症、免疫反应和细胞内信号传导事件中有重要作用。ICAM家族由五个成员组成，命名为ICAM-1至ICAM-5。已知它们在炎症和免疫应答期间与白细胞整合素CD11/CD18如LFA-1和结合。另外，由于细胞表面的激活和蛋白水解机制，ICAM可能以可溶形式存在于人血浆中。 哺乳动物的细胞间黏附分子包括： * * * * * (zh) In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events. The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. In addition, ICAMs may exist in soluble forms in human plasma, due to activation and proteolysis mechanisms at cell surfaces. (en) |
| rdfs:label |
Intercellular adhesion molecule (en) 细胞间黏附分子 (zh) |
| owl:sameAs |
freebase:Intercellular adhesion molecule yago-res:Intercellular adhesion molecule wikidata:Intercellular adhesion molecule dbpedia-gl:Intercellular adhesion molecule dbpedia-zh:Intercellular adhesion molecule https://global.dbpedia.org/id/fYja |
| prov:wasDerivedFrom |
wikipedia-en:Intercellular_adhesion_molecule?oldid=993155916&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/PDB_1iam_EBI.jpg |
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wikipedia-en:Intercellular_adhesion_molecule |
| is dbo:wikiPageRedirects of |
dbr:Intercellular_adhesion_molecules |
| is dbo:wikiPageWikiLink of |
dbr:Allergic_inflammation dbr:List_of_human_clusters_of_differentiation dbr:Pharming_(genetics) dbr:ICAM-1 dbr:Contrast-enhanced_ultrasound dbr:T_helper_cell dbr:Cell_adhesion dbr:Foam_cell dbr:ICAM5 dbr:Immunoglobulin_I-set_domain dbr:Methotrexate dbr:ICAM dbr:Gut-specific_homing dbr:ICAM2 dbr:ICAM3 dbr:ICAM4 dbr:Outline_of_immunology dbr:Uropod_(immunology) dbr:Rap1 dbr:Spermatogenesis dbr:Intercellular_adhesion_molecules |
| is foaf:primaryTopic of |
wikipedia-en:Intercellular_adhesion_molecule |
