James A. Lake (original) (raw)
James A. Lake (born August 10, 1941, Kearney, Nebraska) is an American evolutionary biologist and a Distinguished Professor of Molecular, Cell, and Developmental Biology and of Human Genetics at UCLA. Lake is best known for the New Animal Phylogeny and for the first three-dimensional structure of the ribosome. He has also made significant contributions to understanding genome evolution across all kingdoms of life, including discovering informational and operational genes, elucidating the complexity hypothesis for gene transfer, rooting the tree of life, and understanding the early transition from prokaryotic to eukaryotic life.
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| dbo:abstract | James Albert Lake (* 10. August 1941 in Kearney) ist ein US-amerikanischer Evolutionsbiologe und Molekularbiologe. Lake studierte Physik an der University of Colorado in Boulder mit dem Bachelor-Abschluss 1963 und wurde 1967 an der University of Wisconsin-Madison in Physik promoviert. Seiner Dissertation war über die Struktur von Transfer-RNA. Als Post-Doktorand in Molekularbiologie war er am MIT und an der Harvard Medical School (ab 1968). Ab 1970 war er Assistant Professor am Lehrstuhl für Zellbiologie von George Palade an der Rockefeller University, ar ab 1973 Associate Professor an der New York University Medical School und wurde 1976 Professor für Molekularbiologie an der University of California, Los Angeles (UCLA). Dort ist er Distinguished Professor für Molekular-, Zell- und Entwicklungsbiologie (ab 1996) sowie Humangenetik (ab 2002). Er erforscht mit genetischen Methoden den Stammbaum des Lebens (New Animal Phylogeny), einschließlich der Prokaryoten-Vorläufer der Eukaryoten (siehe Urvorfahr), wobei er genetische Beweise für den Endosymbiose-Ursprung der Eukaryoten lieferte. 2004 entdeckte er dass das eukaryotische Genom aus der Fusion des Genoms einer Eubakterie und einer Archäbakterie entstand. Eine entsprechende Theorie (Eozyten-Hypothese) das Ursprungs der Eukaryoten in den Archäbakterien hatte er schon 1984 aufgestellt. 2009 fand er auch bei Prokaryoten Hinweise auf Endosymbiose in der frühen Stammbaumentwicklung (Gram-negative Bakterien mit doppelter Membran aus Symbiose von frühen Actinobakterien und Clostridium). 2011 erhielt er die Darwin-Wallace-Medaille. Er ist Fellow der Linnean Society of London, der American Academy of Microbiology, der American Association for the Advancement of Science. 1983 wurde er Fellow des Churchill College der Universität Cambridge, 2012 wurde er in die American Academy of Arts and Sciences gewählt. (de) James A. Lake (born August 10, 1941, Kearney, Nebraska) is an American evolutionary biologist and a Distinguished Professor of Molecular, Cell, and Developmental Biology and of Human Genetics at UCLA. Lake is best known for the New Animal Phylogeny and for the first three-dimensional structure of the ribosome. He has also made significant contributions to understanding genome evolution across all kingdoms of life, including discovering informational and operational genes, elucidating the complexity hypothesis for gene transfer, rooting the tree of life, and understanding the early transition from prokaryotic to eukaryotic life. (en) James A. Lake (n. 10 de agosto de 1941, Nebraska-EE.UU.) es un biólogo evolutivo y profesor distinguido de Biología molecular, celular, del desarrollo y Genética humana de la UCLA (imagen). Lake es más conocido por la nueva filogenia animal y por el estudio pionero de la estructura tridimensional del ribosoma. También ha realizado importantes contribuciones a la comprensión de la evolución del genoma en todos los reinos de la vida, incluyendo el descubrimiento de genes informativos y operativos, dilucidando además la complejidad de la transferencia de genes, el enraizamiento del árbol de la vida y la comprensión de la transición temprana desde la vida procariota a la eucariota (eucariogénesis), así como la reconstrucción de la filogenia animal. En 2011 recibió la Medalla Darwin-Wallace de la Sociedad Linneana de Londres en mérito a los avances de su laboratorio en Biología Evolutiva. (es) James Albert Lake, né le 10 août 1941 à Kearney (Nebraska), est un biologiste de l'évolution américain. (fr) |
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| rdfs:comment | James A. Lake (born August 10, 1941, Kearney, Nebraska) is an American evolutionary biologist and a Distinguished Professor of Molecular, Cell, and Developmental Biology and of Human Genetics at UCLA. Lake is best known for the New Animal Phylogeny and for the first three-dimensional structure of the ribosome. He has also made significant contributions to understanding genome evolution across all kingdoms of life, including discovering informational and operational genes, elucidating the complexity hypothesis for gene transfer, rooting the tree of life, and understanding the early transition from prokaryotic to eukaryotic life. (en) James Albert Lake, né le 10 août 1941 à Kearney (Nebraska), est un biologiste de l'évolution américain. (fr) James Albert Lake (* 10. August 1941 in Kearney) ist ein US-amerikanischer Evolutionsbiologe und Molekularbiologe. Lake studierte Physik an der University of Colorado in Boulder mit dem Bachelor-Abschluss 1963 und wurde 1967 an der University of Wisconsin-Madison in Physik promoviert. Seiner Dissertation war über die Struktur von Transfer-RNA. Als Post-Doktorand in Molekularbiologie war er am MIT und an der Harvard Medical School (ab 1968). Ab 1970 war er Assistant Professor am Lehrstuhl für Zellbiologie von George Palade an der Rockefeller University, ar ab 1973 Associate Professor an der New York University Medical School und wurde 1976 Professor für Molekularbiologie an der University of California, Los Angeles (UCLA). Dort ist er Distinguished Professor für Molekular-, Zell- und Entwic (de) James A. Lake (n. 10 de agosto de 1941, Nebraska-EE.UU.) es un biólogo evolutivo y profesor distinguido de Biología molecular, celular, del desarrollo y Genética humana de la UCLA (imagen). Lake es más conocido por la nueva filogenia animal y por el estudio pionero de la estructura tridimensional del ribosoma. También ha realizado importantes contribuciones a la comprensión de la evolución del genoma en todos los reinos de la vida, incluyendo el descubrimiento de genes informativos y operativos, dilucidando además la complejidad de la transferencia de genes, el enraizamiento del árbol de la vida y la comprensión de la transición temprana desde la vida procariota a la eucariota (eucariogénesis), así como la reconstrucción de la filogenia animal. (es) |
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