Junctional adhesion molecule (original) (raw)
Les JAM (pour « junctional adhesion molécule ») sont une famille de protéines transmembranaires.
| Property | Value |
|---|---|
| dbo:abstract | Junctional Adhesion Molecule (JAM) („junktionales Adhäsionsmolekül“, lat. iunction = „Verbindung“) heißen Proteine, die zu einer Untergruppe der gehören. Sie bestehen aus 2 Immunglobulin-ähnlichen Domänen, einer Transmembrandomäne und einer kurzen zytoplasmatischen Domäne. Sie sind nur bei Wirbeltieren vorhanden. JAMs werden von einer Vielzahl verschiedener Zellen exprimiert. Man findet sie vornehmlich in Epithelzellen, Endothelzellen und Zellen des Immunsystems (Leukozyten), aber auch in Zellen des zentralen und peripheren Nervensystems, männlichen Keimzellen und Sertolizellen. In Epithelzellen und Endothelzellen sind die Junctional Adhesion Molecules Bestandteil der Tight Junctions. Innerhalb des Zytoplasmas sind die JAMs mit dem Aktin-Zytoskelett verbunden. (de) A junctional adhesion molecule (JAM) is a protein that is a member of the immunoglobulin superfamily, and is expressed in a variety of different tissues, such as leukocytes, platelets, and epithelial and endothelial cells. They have been shown to regulate signal complex assembly on both their cytoplasmic and extracellular domains through interaction with scaffolding that contains a PDZ domain and adjacent cell's receptors, respectively. JAMs adhere to adjacent cells through interactions with integrins LFA-1 and Mac-1, which are contained in leukocyte β2 and α4β1, which is contained in β1. JAMs have many influences on leukocyte-endothelial cell interactions, which are primarily moderated by the integrins discussed above. They interact in their cytoplasmic domain with scaffold proteins that contain a PDZ domain, which are common protein interaction modules that target short amino acid sequences at the C-terminus of proteins, to form tight junctions in both epithelial and endothelial cells as polarity is gained in the cell. (en) Les JAM (pour « junctional adhesion molécule ») sont une famille de protéines transmembranaires. (fr) JAM（Junctional adhesion molecule）は、細胞間結合の様式の1種であるタイトジャンクション（密着結合）を構成する一群のタンパク質である。 (ja) |
| dbo:symbol | JAM |
| dbo:thumbnail | wiki-commons:Special:FilePath/PDB_1nbq_EBI.jpg?width=300 |
| dbo:wikiPageID | 62456128 (xsd:integer) |
| dbo:wikiPageLength | 15563 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1123059896 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Cataract dbr:Endocytosis dbr:Endothelium dbr:Epithelium dbr:Mouse dbr:Monomer dbr:Homeostasis dbr:Hydrogen_bond dbr:Permeability_(Earth_sciences) dbr:Cytosol dbr:Integrin_alpha_M dbr:Integrin_alpha_V dbr:Integrin_beta_1 dbr:Integrin_beta_2 dbr:Intracerebral_hemorrhage dbr:Reoviridae dbr:Small_intestine dbr:Sertoli_cell dbr:Gene_expression dbr:Vitronectin dbr:Connective_tissue dbr:Cooperativity dbr:Spermatid dbr:Leukocyte dbr:Ligand dbr:Claudin dbr:Platelet dbr:Protein_kinase_B dbc:Proteins dbr:Adherens_junction dbr:Cell_polarity dbr:Ionic_bonding dbr:Large_intestine dbr:Salt_bridge_(protein_and_supramolecular) dbr:Dalton_(unit) dbr:Angiogenesis dbr:Basement_membrane dbc:Immunoglobulin_superfamily dbr:PDZ_domain dbr:Cell_growth dbr:Cell_junction dbr:Cell_migration dbr:Dimer_(chemistry) dbr:Germ_cell dbr:Granulocyte dbr:Endothelial dbr:Epithelial dbr:Protein_domain dbr:Protein dbr:Hydrophobic_effect dbr:Blood_vessel dbr:Blood–testis_barrier dbr:Heterophile_antigen dbr:Signal_transduction dbr:Fibronectin dbr:Immunoglobulin_V-set_domain dbr:Integrin dbr:VISTA_(protein) dbr:White_blood_cell dbr:Immunoglobulin_domain dbr:Immunoglobulin_superfamily dbr:Lymphocyte dbr:Type_IV_collagen dbr:Male_reproductive_system dbr:N-terminus dbr:Tight_junction dbr:Phosphorylation dbr:VLA-4 dbr:PARD3 dbr:LFA-1 dbr:File:Cellular_tight_junction-it.svg |
| dbp:caption | Crystallographic structure of junctional adhesion molecules linked together (en) |
| dbp:membranomeFamily | V set domain (en) |
| dbp:membranomeSuperfamily | Immunoglobulin (en) |
| dbp:name | Junctional Adhesion Molecule (en) |
| dbp:symbol | JAM (en) |
| dbp:wikiPageUsesTemplate | dbt:Citation_needed dbt:Infobox_protein_family dbt:Reflist |
| dcterms:subject | dbc:Proteins dbc:Immunoglobulin_superfamily |
| rdf:type | owl:Thing dbo:Biomolecule wikidata:Q206229 wikidata:Q8054 dbo:Protein |
| rdfs:comment | Les JAM (pour « junctional adhesion molécule ») sont une famille de protéines transmembranaires. (fr) JAM（Junctional adhesion molecule）は、細胞間結合の様式の1種であるタイトジャンクション（密着結合）を構成する一群のタンパク質である。 (ja) Junctional Adhesion Molecule (JAM) („junktionales Adhäsionsmolekül“, lat. iunction = „Verbindung“) heißen Proteine, die zu einer Untergruppe der gehören. Sie bestehen aus 2 Immunglobulin-ähnlichen Domänen, einer Transmembrandomäne und einer kurzen zytoplasmatischen Domäne. Sie sind nur bei Wirbeltieren vorhanden. JAMs werden von einer Vielzahl verschiedener Zellen exprimiert. Man findet sie vornehmlich in Epithelzellen, Endothelzellen und Zellen des Immunsystems (Leukozyten), aber auch in Zellen des zentralen und peripheren Nervensystems, männlichen Keimzellen und Sertolizellen. (de) A junctional adhesion molecule (JAM) is a protein that is a member of the immunoglobulin superfamily, and is expressed in a variety of different tissues, such as leukocytes, platelets, and epithelial and endothelial cells. They have been shown to regulate signal complex assembly on both their cytoplasmic and extracellular domains through interaction with scaffolding that contains a PDZ domain and adjacent cell's receptors, respectively. JAMs adhere to adjacent cells through interactions with integrins LFA-1 and Mac-1, which are contained in leukocyte β2 and α4β1, which is contained in β1. JAMs have many influences on leukocyte-endothelial cell interactions, which are primarily moderated by the integrins discussed above. They interact in their cytoplasmic domain with scaffold proteins that (en) |
| rdfs:label | Junctional Adhesion Molecules (de) JAM (protéine) (fr) Junctional adhesion molecule (en) Junctional adhesion molecule (ja) |
| owl:sameAs | wikidata:Junctional adhesion molecule dbpedia-de:Junctional adhesion molecule dbpedia-fr:Junctional adhesion molecule dbpedia-ja:Junctional adhesion molecule https://global.dbpedia.org/id/5e1U1 |
| prov:wasDerivedFrom | wikipedia-en:Junctional_adhesion_molecule?oldid=1123059896&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Cellular_tight_junction-it.svg wiki-commons:Special:FilePath/PDB_1nbq_EBI.jpg |
| foaf:isPrimaryTopicOf | wikipedia-en:Junctional_adhesion_molecule |
| is dbo:wikiPageDisambiguates of | dbr:Jam_(disambiguation) |
| is dbo:wikiPageRedirects of | dbr:Junctional_adhesion_molecules |
| is dbo:wikiPageWikiLink of | dbr:Reoviridae dbr:Jam_(disambiguation) dbr:IgSF_CAM dbr:Cell_junction dbr:Blood–brain_barrier dbr:Immunoglobulin_V-set_domain dbr:Outline_of_immunology dbr:VSIG1 dbr:Junctional_adhesion_molecules |
| is foaf:primaryTopic of | wikipedia-en:Junctional_adhesion_molecule |
