Kynurenine 3-monooxygenase (original) (raw)
Kynurenin-3-Monooxygenase (KMO) ist ein Enzym, das die Hydroxylierung von Kynurenin zu 3-Hydroxykynurenin katalysiert. Diese Reaktion ist ein Teilschritt im Katabolismus der Aminosäure Tryptophan und der Synthese von NAD und neurologisch aktiver Stoffe. KMO kommt in Tieren und manchen Pilzen und Bakterien vor. Beim Menschen ist sie in größeren Mengen in Leber, Plazenta und im Immunsystem lokalisiert, wobei sie in der Membran der Mitochondrien verankert ist und in das Zytosol ragt.
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| dbo:abstract | En enzimologia, quinurenina 3-monooxigenasa (EC 1.14.13.9) és un enzim que catalitza la reacció química següent: L-quinurenina + NADPH + H+ + O₂ 3-hidroxi-L-quinurenina + NADP+ + H₂O Els quatre substrats d'aquest enzim són la , el NADPH, l' i l'O₂, mentre que els seus tres productes són el , NADP+ i l'H₂O. Aquest enzim pertany a la família de les oxidoreductases, específicament a aquelles que actuen amb dos donadors, amb l'O₂ com a oxidant i incorporador o reductor d'oxigen. L'oxigen incorporat ha de ser derivat del O₂ amb NADH o NADPH com un donador, i la incorporació d'un àtom d'oxigen en un altre donador. El nom estandarditzat d'aquesta classe d'enzim és L-quinurenina, NADPH: oxigen oxidoreductasa (3-hidroxilant). També s'usen diversos noms comuns com quinurenina 3-hidroxilasa, quinureninahidroxilasa i L-quinurenina-3-hidroxilasa. Aquest enzim actua en el metabolisme triptòfan. Empra un cofactor FAD. (ca) Kynurenin-3-Monooxygenase (KMO) ist ein Enzym, das die Hydroxylierung von Kynurenin zu 3-Hydroxykynurenin katalysiert. Diese Reaktion ist ein Teilschritt im Katabolismus der Aminosäure Tryptophan und der Synthese von NAD und neurologisch aktiver Stoffe. KMO kommt in Tieren und manchen Pilzen und Bakterien vor. Beim Menschen ist sie in größeren Mengen in Leber, Plazenta und im Immunsystem lokalisiert, wobei sie in der Membran der Mitochondrien verankert ist und in das Zytosol ragt. (de) In enzymology, a kynurenine 3-monooxygenase (EC 1.14.13.9) is an enzyme that catalyzes the chemical reaction L-kynurenine + NADPH + H+ + O2 ⇌ 3-hydroxy-L-kynurenine + NADP+ + H2O Kynurenine 3-monooxygenase is the expression product of the KMO (gene). The systematic name of this enzyme class is L-kynurenine, NADPH:oxygen oxidoreductase (3-hydroxylating). Other names in common use include kynurenine 3-hydroxylase, kynurenine hydroxylase, and L-kynurenine-3-hydroxylase. It participates in tryptophan metabolism through the kynurenine catabolic pathway. This enzyme belongs to the family of oxidoreductases, to be specific, those acting on paired donors, with O2 as the oxidant. Kynurenine 3-monooxygenase catalyzes the insertion of molecular oxygen into the aromatic ring of kynurenine to produce 3-hydroxy-L-kynurenine. It employs one cofactor, FAD. Kynurenine 3-monooxygenase serves as an important branch point in the kynurenine pathway and, as a result, is an attractive drug target for immunological, neurodegenerative, and neuroinflammatory diseases. Currently, most research on the kynurenine 3-monooxygenase enzyme has been focused primarily on rat models and in yeast, both of which have been demonstrated to have high sequence homology with the human kynurenine 3-monooxygenase protein. Studies have shown the beneficial effects of enzyme inhibition in these eukaryotic kynurenine 3-monooxygenase active sites, thus making this enzyme an attractive target for human drug design. (en) La chinurenina 3-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: L-chinurenina + NADPH + H+ + O2 ⇄ 3-idrossi-L-chinurenina + NADP+ + H2O L'enzima è una flavoproteina (FAD). (it) キヌレニン-3-モノオキシゲナーゼ（英: kynurenine 3-monooxygenase, KMO）は、トリプトファンの主要代謝経路のひとつであるキヌレニン経路で働く酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 L-キヌレニン + NADPH + H+ + O2 3-ヒドロキシ-L-キヌレニン + NADP+ + H2O この酵素の基質はL-キヌレニン、NADPH、H+とO2で、生成物は、NADP+とH2Oである。補酵素としてFADを用いる。 (ja) 3-Monooksygenaza kinureninowa – enzym z grupy oksydoreduktaz. Włącza on atom tlenu do cząsteczki L-kinureniny, używając także NADPH.Produktem jest . Reakcja ta należy do katabolizmu tryptofanu, jednego z aminokwasów egzogennych. Inna nazwa tego enzymu to hydroksylaza kinureninowa. (pl) |
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| dbp:caption | Structure of the kynurenine 3-monooxygenase dimer, generated from 4J34. One monomer is depicted in cartoon format and the second monomer is displayed in ribbon format . The flexible linker regions are colored red. Flavin adenine dinucleotide is shown as spheres color-coded according to atom type. (en) |
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| dbp:name | kynurenine 3-monooxygenase (en) |
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| rdfs:comment | Kynurenin-3-Monooxygenase (KMO) ist ein Enzym, das die Hydroxylierung von Kynurenin zu 3-Hydroxykynurenin katalysiert. Diese Reaktion ist ein Teilschritt im Katabolismus der Aminosäure Tryptophan und der Synthese von NAD und neurologisch aktiver Stoffe. KMO kommt in Tieren und manchen Pilzen und Bakterien vor. Beim Menschen ist sie in größeren Mengen in Leber, Plazenta und im Immunsystem lokalisiert, wobei sie in der Membran der Mitochondrien verankert ist und in das Zytosol ragt. (de) La chinurenina 3-monoossigenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: L-chinurenina + NADPH + H+ + O2 ⇄ 3-idrossi-L-chinurenina + NADP+ + H2O L'enzima è una flavoproteina (FAD). (it) キヌレニン-3-モノオキシゲナーゼ（英: kynurenine 3-monooxygenase, KMO）は、トリプトファンの主要代謝経路のひとつであるキヌレニン経路で働く酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 L-キヌレニン + NADPH + H+ + O2 3-ヒドロキシ-L-キヌレニン + NADP+ + H2O この酵素の基質はL-キヌレニン、NADPH、H+とO2で、生成物は、NADP+とH2Oである。補酵素としてFADを用いる。 (ja) 3-Monooksygenaza kinureninowa – enzym z grupy oksydoreduktaz. Włącza on atom tlenu do cząsteczki L-kinureniny, używając także NADPH.Produktem jest . Reakcja ta należy do katabolizmu tryptofanu, jednego z aminokwasów egzogennych. Inna nazwa tego enzymu to hydroksylaza kinureninowa. (pl) En enzimologia, quinurenina 3-monooxigenasa (EC 1.14.13.9) és un enzim que catalitza la reacció química següent: L-quinurenina + NADPH + H+ + O₂ 3-hidroxi-L-quinurenina + NADP+ + H₂O Els quatre substrats d'aquest enzim són la , el NADPH, l' i l'O₂, mentre que els seus tres productes són el , NADP+ i l'H₂O. (ca) In enzymology, a kynurenine 3-monooxygenase (EC 1.14.13.9) is an enzyme that catalyzes the chemical reaction L-kynurenine + NADPH + H+ + O2 ⇌ 3-hydroxy-L-kynurenine + NADP+ + H2O Kynurenine 3-monooxygenase is the expression product of the KMO (gene). The systematic name of this enzyme class is L-kynurenine, NADPH:oxygen oxidoreductase (3-hydroxylating). Other names in common use include kynurenine 3-hydroxylase, kynurenine hydroxylase, and L-kynurenine-3-hydroxylase. It participates in tryptophan metabolism through the kynurenine catabolic pathway. This enzyme belongs to the family of oxidoreductases, to be specific, those acting on paired donors, with O2 as the oxidant. Kynurenine 3-monooxygenase catalyzes the insertion of molecular oxygen into the aromatic ring of kynurenine to produce 3 (en) |
| rdfs:label | Quinurenina 3-monooxigenasa (ca) Kynurenin-3-Monooxygenase (de) Chinurenina 3-monoossigenasi (it) Kynurenine 3-monooxygenase (en) キヌレニン-3-モノオキシゲナーゼ (ja) 3-Monooksygenaza kinureninowa (pl) |
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