Lometraline (original) (raw)
Lometraline (INN; developmental code name CP-14,368) is a drug and an aminotetralin derivative. A structural modification of tricyclic neuroleptics, lometraline was originally patented by Pfizer as an antipsychotic, tranquilizer, and antiparkinsonian agent. However, it was instead later studied as a potential antidepressant and/or anxiolytic agent, though clinical studies revealed no psychoactivity at the doses used and further investigation was suspended. Further experimental modifications of the chemical structure of lometraline resulted in the discovery of tametraline, a potent inhibitor of the reuptake of dopamine and norepinephrine, which in turn led to the discovery of the now widely popular antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI).
| Property | Value |
|---|---|
| dbo:abstract | Lometraline (INN; developmental code name CP-14,368) is a drug and an aminotetralin derivative. A structural modification of tricyclic neuroleptics, lometraline was originally patented by Pfizer as an antipsychotic, tranquilizer, and antiparkinsonian agent. However, it was instead later studied as a potential antidepressant and/or anxiolytic agent, though clinical studies revealed no psychoactivity at the doses used and further investigation was suspended. Further experimental modifications of the chemical structure of lometraline resulted in the discovery of tametraline, a potent inhibitor of the reuptake of dopamine and norepinephrine, which in turn led to the discovery of the now widely popular antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI). (en) |
| dbo:casNumber | 34552-78-8 (hydrochloride) 39951-65-0 |
| dbo:chEMBL | 2111119 |
| dbo:fdaUniiCode | V78B234QEY |
| dbo:kegg | D02669 |
| dbo:pubchem | 34789 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Lometraline.svg?width=300 |
| dbo:wikiPageID | 35642404 (xsd:integer) |
| dbo:wikiPageLength | 4256 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1082622336 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Potency_(pharmacology) dbr:Pfizer dbc:1-Aminotetralins dbr:Reuptake_inhibitor dbc:Chloroarenes dbc:Dimethylamino_compounds dbr:Chemical_structure dbr:Antidepressant dbr:Antipsychotic dbr:Anxiolytic dbr:Management_of_Parkinson's_disease dbr:Drug dbr:Norepinephrine dbr:International_Nonproprietary_Name dbr:Tametraline dbr:Hydrochloride dbc:Psychoactive_drugs dbr:Tranquilizer dbr:Dopamine dbr:Neuroleptic dbr:Selective_serotonin_reuptake_inhibitor dbr:Sertraline dbr:Reuptake dbr:Psychoactivity dbr:Tricyclic_compound dbr:Aminotetralin dbr:Chemical_derivative dbr:Structural_modification |
| dbp:atcPrefix | None (en) |
| dbp:c | 13 (xsd:integer) |
| dbp:casNumber | 39951 (xsd:integer) |
| dbp:casSupplemental | 34552 (xsd:integer) |
| dbp:chembl | 2111119 (xsd:integer) |
| dbp:chemspiderid | 32014 (xsd:integer) |
| dbp:cl | 1 (xsd:integer) |
| dbp:h | 18 (xsd:integer) |
| dbp:iupacName | 8 (xsd:integer) |
| dbp:kegg | D02669 (en) |
| dbp:n | 1 (xsd:integer) |
| dbp:o | 1 (xsd:integer) |
| dbp:pubchem | 34789 (xsd:integer) |
| dbp:smiles | Clc1cccc2c1CCCC2 (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | MTWNWMGGMZUIMZ-UHFFFAOYSA-N (en) |
| dbp:synonyms | N,N-dimethyl-8-chloro-5-methoxy-1-aminotetralin (en) |
| dbp:unii | V78B234QEY (en) |
| dbp:width | 150 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Drugbox dbt:Reflist dbt:Short_description |
| dcterms:subject | dbc:1-Aminotetralins dbc:Chloroarenes dbc:Dimethylamino_compounds dbc:Psychoactive_drugs |
| gold:hypernym | dbr:Drug |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatAmines yago:Abstraction100002137 yago:AliphaticCompound114601294 yago:Amine114739004 yago:Chemical114806838 yago:Compound114818238 yago:Material114580897 yago:Matter100020827 yago:MethaneSeries114951377 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:Drug yago:Substance100019613 |
| rdfs:comment | Lometraline (INN; developmental code name CP-14,368) is a drug and an aminotetralin derivative. A structural modification of tricyclic neuroleptics, lometraline was originally patented by Pfizer as an antipsychotic, tranquilizer, and antiparkinsonian agent. However, it was instead later studied as a potential antidepressant and/or anxiolytic agent, though clinical studies revealed no psychoactivity at the doses used and further investigation was suspended. Further experimental modifications of the chemical structure of lometraline resulted in the discovery of tametraline, a potent inhibitor of the reuptake of dopamine and norepinephrine, which in turn led to the discovery of the now widely popular antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI). (en) |
| rdfs:label | Lometraline (en) |
| owl:sameAs | freebase:Lometraline yago-res:Lometraline wikidata:Lometraline dbpedia-sh:Lometraline dbpedia-sr:Lometraline https://global.dbpedia.org/id/YUVP |
| prov:wasDerivedFrom | wikipedia-en:Lometraline?oldid=1082622336&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Lometraline.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Lometraline |
| is dbo:wikiPageWikiLink of | dbr:Desmethylsertraline dbr:2-Aminotetralin dbr:Dasotraline dbr:PPPA_(drug) dbr:Tametraline dbr:Chlorprothixene dbr:C13H18ClNO dbr:Sertraline dbr:List_of_drugs:_Lo |
| is foaf:primaryTopic of | wikipedia-en:Lometraline |
