Homeobox protein MSX-1 (original) (raw)
Homeobox protein MSX-1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and is responsive to thyroid hormone. MSX1 is also expressed in highly differentiated pituitary cells which until recently was thought to be expressed exclusively during embryogenesis. There is a highly conserved structural organization of the members of the MSX family of genes and their abundant expression at sites of inductive cell–cell interactions in the embryo suggest that they have a pivotal role during early development.
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| dbo:abstract | Homeobox protein MSX-1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and is responsive to thyroid hormone. MSX1 is also expressed in highly differentiated pituitary cells which until recently was thought to be expressed exclusively during embryogenesis. There is a highly conserved structural organization of the members of the MSX family of genes and their abundant expression at sites of inductive cell–cell interactions in the embryo suggest that they have a pivotal role during early development. (en) Msh homeobox 1, también conocida como MSX1, es una proteína codificada en humanos por el gen msx1. (es) MSX1 (англ. Msh homeobox 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 4-ї хромосоми. Довжина поліпептидного ланцюга білка становить 303 амінокислот, а молекулярна маса — 31 496. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функціями належить до репресорів, . Задіяний у таких біологічних процесах як транскрипція, регуляція транскрипції. Білок має сайт для зв'язування з ДНК. Локалізований у ядрі. (uk) |
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| dbo:wikiPageWikiLink | dbr:Protein-protein_interaction dbr:Sp1_transcription_factor dbr:Homeobox dbr:Hypodontia dbr:DLX5 dbr:Gene dbr:Cleft_lip_and_palate dbr:TATA_binding_protein dbr:DLX2 dbr:Protein dbr:Craniofacial dbc:Transcription_factors dbr:Embryogenesis dbr:Msh_homeobox_2 dbr:Wolf–Hirschhorn_syndrome dbr:Witkop_syndrome dbr:Odontogenesis dbr:CREB_binding_protein |
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| dct:subject | dbc:Transcription_factors |
| rdf:type | owl:Thing dbo:Biomolecule dbo:Gene wikidata:Q206229 wikidata:Q7187 dbo:HumanGene |
| rdfs:comment | Homeobox protein MSX-1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and is responsive to thyroid hormone. MSX1 is also expressed in highly differentiated pituitary cells which until recently was thought to be expressed exclusively during embryogenesis. There is a highly conserved structural organization of the members of the MSX family of genes and their abundant expression at sites of inductive cell–cell interactions in the embryo suggest that they have a pivotal role during early development. (en) Msh homeobox 1, también conocida como MSX1, es una proteína codificada en humanos por el gen msx1. (es) MSX1 (англ. Msh homeobox 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 4-ї хромосоми. Довжина поліпептидного ланцюга білка становить 303 амінокислот, а молекулярна маса — 31 496. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk) |
| rdfs:label | MSX1 (es) Homeobox protein MSX-1 (en) MSX1 (uk) |
| owl:differentFrom | dbr:MSX |
| owl:sameAs | wikidata:Homeobox protein MSX-1 dbpedia-cy:Homeobox protein MSX-1 dbpedia-es:Homeobox protein MSX-1 http://tt.dbpedia.org/resource/MSX1 dbpedia-uk:Homeobox protein MSX-1 https://global.dbpedia.org/id/jgzS |
| prov:wasDerivedFrom | wikipedia-en:Homeobox_protein_MSX-1?oldid=1113528241&ns=0 |
| foaf:isPrimaryTopicOf | wikipedia-en:Homeobox_protein_MSX-1 |
| is dbo:wikiPageRedirects of | dbr:MSX1_(gene) dbr:MSX1 dbr:Msx1_transcription_factor |
| is dbo:wikiPageWikiLink of | dbr:MSX1_(gene) dbr:MSX1 dbr:Msx1_transcription_factor |
| is foaf:primaryTopic of | wikipedia-en:Homeobox_protein_MSX-1 |