Maresin (original) (raw)
Maresin 1 (MaR1 or 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid) is a macrophage-derived mediator of inflammation resolution coined from macrophage mediator in resolving inflammation. Maresin 1, and more recently defined maresins, are 12-lipoxygenase-derived metabolites of the omega-3 fatty acid, docosahexaenoic acid (DHA), that possess potent anti-inflammatory, pro-resolving, protective, and pro-healing properties similar to a variety of other members of the specialized proresolving mediators (SPM) class of polyunsaturated fatty acid (PUFA) metabolites. SPM are dihydroxy, trihydroxy, and epoxy-hydroxy metabolites of long chain PUFA made by certain dioxygenase enzymes viz., cyclooxygenases and lipoxygenases. In addition to the maresins, this class of mediators includes: the
| Property | Value |
|---|---|
| dbo:abstract | Maresin 1 (MaR1 or 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid) is a macrophage-derived mediator of inflammation resolution coined from macrophage mediator in resolving inflammation. Maresin 1, and more recently defined maresins, are 12-lipoxygenase-derived metabolites of the omega-3 fatty acid, docosahexaenoic acid (DHA), that possess potent anti-inflammatory, pro-resolving, protective, and pro-healing properties similar to a variety of other members of the specialized proresolving mediators (SPM) class of polyunsaturated fatty acid (PUFA) metabolites. SPM are dihydroxy, trihydroxy, and epoxy-hydroxy metabolites of long chain PUFA made by certain dioxygenase enzymes viz., cyclooxygenases and lipoxygenases. In addition to the maresins, this class of mediators includes: the 15-lipoxygenase (i.e. ALOX15 and/or possibly ALOX15B)-derived Lipoxin A4 and B4 metabolites of the omega 6 fatty acid, arachidonic acid; the cyclooxygenase 2-derived Resolvin E series metabolites of the omega 3 fatty acid, eicosapentaenoic acid; certain 15-lipoxygenase-derived Resolvin D series metabolites of DHA; certain other 15-lipoxygenase-derived protectin D1 and related metabolites of DHA; and the more recently defined and therefore less fully studied 15-lipoxygenase-derived Resolvin Dn-3DPA metabolites of the omega-3 fatty acid n-3 docosapentaenoic acid (n-3 DPA or clupanodonic acid), the cyclooxygenase 2-derived Resolvin T metabolites of this clupanodonic acid, and the 15-lipoxygenase-derived products of the N-acetylated fatty acid amide of the DHA metabolite, docosahexaenoyl ethanolamide (see resolvins). (en) |
| dbo:iupacName | (4Z,7R,8E,10E,12Z,14S,16Z,19Z)-7,14-Dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/Maresin_1.svg?width=300 |
| dbo:wikiPageID | 29909074 (xsd:integer) |
| dbo:wikiPageLength | 15309 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1111528138 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Protectin_D1 dbr:Monocyte dbr:Planaria dbr:Regulatory_T_cells dbr:Rheumatoid_arthritis dbr:Cyclooxygenase dbr:Innate_lymphoid_cell dbc:Lipids dbr:Omega-3_fatty_acid dbr:Phagocytosis dbr:Porphyromonas_gingivalis dbr:TRPV1 dbr:Eicosapentaenoic_acid dbr:Epoxy dbr:Arachidonic_acid dbr:Leukotriene-A4_hydrolase dbr:Leukotriene_A4 dbr:Leukotriene_B4 dbr:Lipoxin dbr:Aggregatibacter_actinomycetemcomitans dbc:Docosanoids dbr:Docosapentaenoic_acid dbr:Ion_channel dbr:Lipoxygenase dbr:Acute_respiratory_distress_syndrome dbr:Cytokines dbr:Dioxygenase dbr:ALOX15 dbr:ALOX15B dbr:Efferocytosis dbr:Docosahexaenoic_acid dbr:Apoptotic dbr:Platelets dbr:Macrophage dbr:Specialized_proresolving_mediators dbr:Neutrophil dbr:Polyunsaturated_fatty_acid dbr:Resolvin dbr:5-lipoxygenase dbr:Interleukin-13 dbr:Interleukin-5 dbr:12-lipoxygenase dbr:Cyclooxygenase_2 dbr:Localized_aggressive_periodontitis dbr:Omega_6_fatty_acid |
| dbp:imagefile | Maresin 1.svg (en) |
| dbp:imagesize | 250 (xsd:integer) |
| dbp:name | Maresin 1 (en) |
| dbp:pin | -714 (xsd:integer) |
| dbp:wikiPageUsesTemplate | dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Technical dbt:Cascite dbt:Fdacite |
| dcterms:subject | dbc:Lipids dbc:Docosanoids |
| gold:hypernym | dbr:Mediator |
| rdf:type | owl:Thing dbo:Person dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q11173 yago:WikicatLipids yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Lipid114938907 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Relation100031921 dbo:ChemicalCompound yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 |
| rdfs:comment | Maresin 1 (MaR1 or 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid) is a macrophage-derived mediator of inflammation resolution coined from macrophage mediator in resolving inflammation. Maresin 1, and more recently defined maresins, are 12-lipoxygenase-derived metabolites of the omega-3 fatty acid, docosahexaenoic acid (DHA), that possess potent anti-inflammatory, pro-resolving, protective, and pro-healing properties similar to a variety of other members of the specialized proresolving mediators (SPM) class of polyunsaturated fatty acid (PUFA) metabolites. SPM are dihydroxy, trihydroxy, and epoxy-hydroxy metabolites of long chain PUFA made by certain dioxygenase enzymes viz., cyclooxygenases and lipoxygenases. In addition to the maresins, this class of mediators includes: the (en) |
| rdfs:label | Maresin (en) |
| owl:sameAs | freebase:Maresin yago-res:Maresin wikidata:Maresin https://global.dbpedia.org/id/4rSpB |
| prov:wasDerivedFrom | wikipedia-en:Maresin?oldid=1111528138&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Maresin_1.svg |
| foaf:isPrimaryTopicOf | wikipedia-en:Maresin |
| foaf:name | Maresin 1 (en) |
| is dbo:wikiPageRedirects of | dbr:Maresins |
| is dbo:wikiPageWikiLink of | dbr:Undurti_Narasimha_Das dbr:C22H32O4 dbr:Inflammation dbr:Nutritional_immunology dbr:TRPV1 dbr:Lipoxin dbr:Docosapentaenoic_acid dbr:Dihydroxy-E,Z,E-PUFA dbr:Aspirin dbr:ALOX12 dbr:Efferocytosis dbr:Resolvin dbr:Specialized_pro-resolving_mediators dbr:TRPA1 dbr:Maresins |
| is foaf:primaryTopic of | wikipedia-en:Maresin |
