Menatetrenone (original) (raw)
Menatetrenone (INN), also known as MK-4, is one of the nine forms of vitamin K2. MK-4 is produced via conversion of vitamin K1 in the body, in the testes, pancreas and arterial walls. While major questions still surround the biochemical pathway for the transformation of vitamin K1 to MK-4, studies demonstrate the conversion is not dependent on gut bacteria, occurring in germ-free rats and in parenterally-administered K1 in rats. Tissues that accumulate high amounts of MK-4 have a capacity to convert up to 90% of the available K1 into MK-4.
| Property | Value |
|---|---|
| dbo:abstract | Menatetrenone (INN), also known as MK-4, is one of the nine forms of vitamin K2. MK-4 is produced via conversion of vitamin K1 in the body, in the testes, pancreas and arterial walls. While major questions still surround the biochemical pathway for the transformation of vitamin K1 to MK-4, studies demonstrate the conversion is not dependent on gut bacteria, occurring in germ-free rats and in parenterally-administered K1 in rats. Tissues that accumulate high amounts of MK-4 have a capacity to convert up to 90% of the available K1 into MK-4. (en) La ménatétrénone (DCI), également connue sous le nom de MK-4, est un composé de vitamine K utilisé comme agent hémostatique et comme traitement d'appoint pour la douleur de l'ostéoporose. La ménatétrénone est l'une des neuf formes de vitamine K2. Le MK-4 est produit par conversion de la vitamine K1 dans le corps, dans les testicules, le pancréas et les parois artérielles. Bien que des questions majeures entourent toujours la voie biochimique pour la transformation de la vitamine K1 en MK-4, des études démontrent que la conversion ne dépend pas des bactéries intestinales, survenant chez les rats sans germes et dans le K1 administré par voie parentérale. chez le rat. En fait, les tissus qui accumulent de grandes quantités de MK-4 ont une capacité remarquable de convertir jusqu'à 90 % du K1 disponible en MK-4. (fr) |
| dbo:casNumber | 863-61-6 |
| dbo:chEBI | 78277 |
| dbo:fdaUniiCode | 27Y876D139 |
| dbo:kegg | D00100 |
| dbo:pubchem | 5282367 |
| dbo:thumbnail | wiki-commons:Special:FilePath/Menatetrenone.png?width=300 |
| dbo:wikiPageID | 9695865 (xsd:integer) |
| dbo:wikiPageLength | 6126 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID | 1117140177 (xsd:integer) |
| dbo:wikiPageWikiLink | dbr:Vitamin_K2 dbc:1,4-Naphthoquinones dbc:Diterpenes dbc:Vitamin_K dbr:International_Nonproprietary_Name |
| dbp:alt | Space-filling model of the menatetrenone molecule (en) Structural formula of menatetrenone (en) |
| dbp:atcPrefix | None (en) |
| dbp:c | 31 (xsd:integer) |
| dbp:casNumber | 863 (xsd:integer) |
| dbp:chebi | 78277 (xsd:integer) |
| dbp:chemspiderid | 4445530 (xsd:integer) |
| dbp:h | 40 (xsd:integer) |
| dbp:image | Menatetrenone molecule spacefill.png (en) |
| dbp:iupacName | 2 (xsd:integer) |
| dbp:kegg | D00100 (en) |
| dbp:o | 2 (xsd:integer) |
| dbp:pubchem | 5282367 (xsd:integer) |
| dbp:routesOfAdministration | Oral (en) |
| dbp:smiles | CC1=CC/C=C/CC/C=C/CC/C=C/CCC=CC (en) |
| dbp:stdinchi | 1 (xsd:integer) |
| dbp:stdinchikey | DKHGMERMDICWDU-GHDNBGIDSA-N (en) |
| dbp:synonyms | (3-methyl-2-[-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione) (en) |
| dbp:unii | 27 (xsd:integer) |
| dbp:verifiedfields | changed (en) |
| dbp:verifiedrevid | 451239229 (xsd:integer) |
| dbp:watchedfields | changed (en) |
| dbp:width | 260 (xsd:integer) |
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| dcterms:subject | dbc:1,4-Naphthoquinones dbc:Diterpenes dbc:Vitamin_K |
| gold:hypernym | dbr:Compound |
| rdf:type | owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatMolecularFormulas yago:WikicatNaphthoquinones yago:WikicatVitamins yago:Abstraction100002137 yago:Communication100033020 yago:Fat-solubleVitamin115089472 yago:Food100021265 yago:Formula106816935 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:Nutriment107570720 yago:PhysicalEntity100001930 dbo:ChemicalCompound dbo:Drug yago:Statement106722453 yago:Substance100020090 yago:Vitamin115089258 yago:VitaminK115092751 umbel-rc:DrugProduct |
| rdfs:comment | Menatetrenone (INN), also known as MK-4, is one of the nine forms of vitamin K2. MK-4 is produced via conversion of vitamin K1 in the body, in the testes, pancreas and arterial walls. While major questions still surround the biochemical pathway for the transformation of vitamin K1 to MK-4, studies demonstrate the conversion is not dependent on gut bacteria, occurring in germ-free rats and in parenterally-administered K1 in rats. Tissues that accumulate high amounts of MK-4 have a capacity to convert up to 90% of the available K1 into MK-4. (en) La ménatétrénone (DCI), également connue sous le nom de MK-4, est un composé de vitamine K utilisé comme agent hémostatique et comme traitement d'appoint pour la douleur de l'ostéoporose. La ménatétrénone est l'une des neuf formes de vitamine K2. (fr) |
| rdfs:label | Ménatétrénone (fr) Menatetrenone (en) |
| owl:sameAs | freebase:Menatetrenone yago-res:Menatetrenone wikidata:Menatetrenone dbpedia-fi:Menatetrenone dbpedia-fr:Menatetrenone dbpedia-sh:Menatetrenone dbpedia-sr:Menatetrenone https://global.dbpedia.org/id/qbqw |
| prov:wasDerivedFrom | wikipedia-en:Menatetrenone?oldid=1117140177&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/Menatetrenone.png wiki-commons:Special:FilePath/Menatetrenone_molecule_spacefill.png |
| foaf:isPrimaryTopicOf | wikipedia-en:Menatetrenone |
| is dbo:wikiPageRedirects of | dbr:Glakay dbr:C31H40O2 dbr:Menaquinone-4 |
| is dbo:wikiPageWikiLink of | dbr:Vitamin_K2 dbr:MK4 dbr:Glakay dbr:C31H40O2 dbr:Hypoprothrombinemia dbr:Phytomenadione dbr:Menaquinone-4 dbr:Naphthoquinone dbr:List_of_drugs:_Me–Meo |
| is foaf:primaryTopic of | wikipedia-en:Menatetrenone |
