| dbo:abstract |
Metaraminol (Handelsnamen Aramine und Araminon) ist ein Arzneistoff aus der Gruppe der Sympathomimetika zur Behandlung von zu niedrigem Blutdruck (Hypotonie). Metaraminol ist nicht für die Behandlung einer Dauererektion (Priapismus), zugelassen, es existieren jedoch Fallberichte von erfolgreicher Anwendung.Der Wirkstoff wird zudem zur Provokation eines vermuteten Familiären Mittelmeerfiebers (FMF) angewendet. Dabei wird dem Patienten eine einmalige 10-mg-Dosis verabreicht; erfolgt während der nächsten 48 Stunden ein Anfall, ist dies ein Hinweis für das Vorliegen von FMF. (de) Metaraminol, previously sold under the brand name Aramine among others and also known as metaradrine, is a stereoisomer of meta-hydroxynorephedrine (3,β-dihydroxyamphetamine), is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. It is an α1-adrenergic receptor agonist with some β effect. It is currently sold in its generic form by Slayback Pharma. (en) Metaraminol ou metaradrina (nomes comerciais: Aramin, Aramine, entre outros) é uma amina simpaticomimética utilizada na prevenção e tratamento da hipotensão arterial, particularmente em casos de complicações relacionadas à anestesia. Atua principalmente como agonista do receptor adrenérgico alfa 1A, exercendo menor ação agonista sobre o receptor adrenérgico beta. (pt) |
| dbo:alternativeName |
Aramine, Metaramin, Pressonex (en) |
| dbo:casNumber |
33402-03-8 (bitartrate) 54-49-9 |
| dbo:chEBI |
6794 |
| dbo:chEMBL |
1201319 |
| dbo:drugbank |
DB00610 |
| dbo:fdaUniiCode |
818U2PZ2EH |
| dbo:kegg |
D08192 |
| dbo:pubchem |
5906 |
| dbo:thumbnail |
wiki-commons:Special:FilePath/Metaraminol_Structural_Formulae.png?width=300 |
| dbo:wikiPageExternalLink |
https://druginfo.nlm.nih.gov/drugportal/name/metaraminol https://druginfo.nlm.nih.gov/drugportal/name/metaraminol%20bitartrate |
| dbo:wikiPageID |
7019609 (xsd:integer) |
| dbo:wikiPageLength |
8478 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1118261724 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Priapism dbr:Meta-Hydroxynorephedrine dbr:Bitartrate dbr:Beta-adrenergic_agonist dbr:Intravenous_therapy dbc:Phenols dbr:Anesthesia dbr:Liver dbr:Stereoisomer dbc:Phenylethanolamines dbr:Adrenergic_receptor dbr:Agonist dbc:Alpha-1_adrenergic_receptor_agonists dbr:Alpha-adrenergic_agonist dbr:Noradrenaline dbc:Substituted_amphetamines dbr:Hypotension dbc:Beta-adrenergic_agonists dbc:Cardiac_stimulants dbr:Reflex_bradycardia dbr:Endotracheal_intubation dbr:Intravenously dbr:Vasopressor dbr:Sympathomimetic_amine dbr:Alpha_adrenergic dbr:File:Metaraminol_prefilledsyringe.jpg |
| dbp:atcPrefix |
1.0 |
| dbp:atcSuffix |
CA09 (en) |
| dbp:bioavailability |
n/a (en) |
| dbp:c |
9 (xsd:integer) |
| dbp:casNumber |
54 (xsd:integer) |
| dbp:casSupplemental |
33402 (xsd:integer) |
| dbp:chebi |
6794 (xsd:integer) |
| dbp:chembl |
1201319 (xsd:integer) |
| dbp:chemspiderid |
5695 (xsd:integer) |
| dbp:dailymedid |
Metaraminol (en) |
| dbp:drugbank |
DB00610 (en) |
| dbp:h |
13 (xsd:integer) |
| dbp:iupacName |
-3 (xsd:integer) |
| dbp:iupharLigand |
7229 (xsd:integer) |
| dbp:kegg |
D08192 (en) |
| dbp:legalAu |
S4 (en) |
| dbp:legalUk |
POM (en) |
| dbp:legalUs |
Rx-only (en) |
| dbp:metabolism |
dbr:Liver |
| dbp:n |
1 (xsd:integer) |
| dbp:o |
2 (xsd:integer) |
| dbp:pregnancyAu |
C (en) |
| dbp:proteinBound |
~45% (en) |
| dbp:pubchem |
5906 (xsd:integer) |
| dbp:routesOfAdministration |
dbr:Intravenous_therapy dbr:Endotracheal_intubation |
| dbp:smiles |
O[C@H][C@@H]C (en) |
| dbp:stdinchi |
1 (xsd:integer) |
| dbp:stdinchikey |
WXFIGDLSSYIKKV-RCOVLWMOSA-N (en) |
| dbp:tradename |
Aramine, Metaramin, Pressonex (en) |
| dbp:unii |
818 (xsd:integer) |
| dbp:verifiedfields |
changed (en) |
| dbp:verifiedrevid |
462249333 (xsd:integer) |
| dbp:wikiPageUsesTemplate |
dbt:Adrenergic_receptor_modulators dbt:Cite_web dbt:Infobox_drug dbt:Phenethylamines dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:Use_dmy_dates dbt:Cascite dbt:Chemspidercite dbt:Drugbankcite dbt:Ebicite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Drugs.com dbt:Cardiovascular-drug-stub dbt:Cardiac_stimulants |
| dcterms:subject |
dbc:Phenols dbc:Phenylethanolamines dbc:Alpha-1_adrenergic_receptor_agonists dbc:Substituted_amphetamines dbc:Beta-adrenergic_agonists dbc:Cardiac_stimulants |
| gold:hypernym |
dbr:Amine |
| rdf:type |
owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 yago:WikicatCardiacStimulants yago:Abstraction100002137 yago:Chemical114806838 yago:Cognition100023271 yago:Compound114818238 yago:Information105816287 yago:Material114580897 yago:Matter100020827 yago:OrganicCompound114727670 yago:Part113809207 yago:Phenol114989545 yago:PhysicalEntity100001930 yago:PsychologicalFeature100023100 yago:Relation100031921 dbo:ChemicalCompound dbo:Drug yago:Stimulation105827684 yago:Substance100019613 yago:WikicatPhenols umbel-rc:DrugProduct |
| rdfs:comment |
Metaraminol (Handelsnamen Aramine und Araminon) ist ein Arzneistoff aus der Gruppe der Sympathomimetika zur Behandlung von zu niedrigem Blutdruck (Hypotonie). Metaraminol ist nicht für die Behandlung einer Dauererektion (Priapismus), zugelassen, es existieren jedoch Fallberichte von erfolgreicher Anwendung.Der Wirkstoff wird zudem zur Provokation eines vermuteten Familiären Mittelmeerfiebers (FMF) angewendet. Dabei wird dem Patienten eine einmalige 10-mg-Dosis verabreicht; erfolgt während der nächsten 48 Stunden ein Anfall, ist dies ein Hinweis für das Vorliegen von FMF. (de) Metaraminol, previously sold under the brand name Aramine among others and also known as metaradrine, is a stereoisomer of meta-hydroxynorephedrine (3,β-dihydroxyamphetamine), is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. It is an α1-adrenergic receptor agonist with some β effect. It is currently sold in its generic form by Slayback Pharma. (en) Metaraminol ou metaradrina (nomes comerciais: Aramin, Aramine, entre outros) é uma amina simpaticomimética utilizada na prevenção e tratamento da hipotensão arterial, particularmente em casos de complicações relacionadas à anestesia. Atua principalmente como agonista do receptor adrenérgico alfa 1A, exercendo menor ação agonista sobre o receptor adrenérgico beta. (pt) |
| rdfs:label |
Metaraminol (de) Metaraminol (en) Metaraminol (pt) |
| owl:sameAs |
freebase:Metaraminol yago-res:Metaraminol http://www4.wiwiss.fu-berlin.de/drugbank/resource/drugs/DB00610 wikidata:Metaraminol http://azb.dbpedia.org/resource/متارامینول dbpedia-cy:Metaraminol dbpedia-de:Metaraminol dbpedia-fa:Metaraminol dbpedia-pt:Metaraminol dbpedia-sh:Metaraminol dbpedia-sr:Metaraminol dbpedia-vi:Metaraminol https://global.dbpedia.org/id/3o1gn |
| prov:wasDerivedFrom |
wikipedia-en:Metaraminol?oldid=1118261724&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/Metaraminol_Structural_Formulae.png wiki-commons:Special:FilePath/Metaraminol_prefilledsyringe.jpg |
| foaf:isPrimaryTopicOf |
wikipedia-en:Metaraminol |
| is dbo:wikiPageRedirects of |
dbr:ATC_code_C01CA09 dbr:ATCvet_code_QC01CA09 dbr:Icoral_B dbr:Aramine dbr:Metaraminol_bitartrate dbr:Metaradrine dbr:Metaraminol_tartrate dbr:Pressonex dbr:Pressorol |
| is dbo:wikiPageWikiLink of |
dbr:List_of_adrenergic_drugs dbr:Meta-Hydroxynorephedrine dbr:Antihypotensive_agent dbr:List_of_MeSH_codes_(D02) dbr:C9H13NO2 dbr:Ephedrine dbr:Gepefrine dbr:Adrenergic_receptor dbr:Alpha-1A_adrenergic_receptor dbr:Alpha-1_adrenergic_receptor dbr:Alpha-adrenergic_agonist dbr:Familial_Mediterranean_fever dbr:Norfenefrine dbr:Rapid_sequence_induction dbr:ATC_code_C01CA09 dbr:ATCvet_code_QC01CA09 dbr:ATC_code_C01 dbr:Icoral_B dbr:Diazepam dbr:Aramine dbr:Aramist dbr:Metaraminol_bitartrate dbr:Dihydroxyamphetamine dbr:List_of_drugs:_Met dbr:Metaradrine dbr:Metaraminol_tartrate dbr:Pressonex dbr:Pressorol |
| is foaf:primaryTopic of |
wikipedia-en:Metaraminol |
