| dbo:abstract |
In enzymology, a methylmalonate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.27) is an enzyme that catalyzes the chemical reaction 2-methyl-3-oxopropanoate + CoA + H2O + NAD+ ⇌ propanoyl-CoA + HCO3- + NADH The 4 substrates of this enzyme are 2-methyl-3-oxopropanoate, CoA, H2O, and NAD+, whereas its 3 products are propanoyl-CoA, HCO3-, and NADH. This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating). Other names in common use include MSDH, and MMSA dehydrogenase. This enzyme participates in 3 metabolic pathways: inositol metabolism, valine, leucine and isoleucine degradation, and propanoate metabolism. (en) メチルマロン酸セミアルデヒドデヒドロゲナーゼ (アシル化)（methylmalonate-semialdehyde dehydrogenase (acylating)、MSDH）は、バリン・ロイシン・イソロイシン分解、イノシトール代謝、プロピオン酸代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 2-メチル-3-オキソプロパン酸 + CoA + NAD+ プロパノイルCoA + CO2 + NADH + H+ 反応式の通り、この酵素の基質は2-メチル-3-オキソプロパン酸（メチルマロン酸セミアルデヒド）とCoAとNAD+、生成物はプロパノイルCoAとCO2とNADHとH+である。 組織名は2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)で、別名にMMSA dehydrogenaseがある。 (ja) La metilmalonato-semialdeide deidrogenasi (acilante) è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 2-metil-3-ossopropanoato + CoA + H2O + NAD+ ⇄ propanoil-CoA + HCO3- + NADH L'enzima converte anche il 3-ossopropanoato in acetil-CoA. La reazione avviene in due passaggi, con il processo di decarbossilazione che precede il legame del CoA. Come prodotto finale è rilasciato bicarbonato anziché CO2. (it) |
| dbo:ecNumber |
1.2.1.27 |
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wiki-commons:Special:FilePath/1t90.jpg?width=300 |
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https://hal.univ-lorraine.fr/hal-01681502/file/S0907444904012533.pdf |
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Methylmalonate semialdehyde dehydrogenase tetramer, Bacillus subtilis (en) |
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| rdfs:comment |
メチルマロン酸セミアルデヒドデヒドロゲナーゼ (アシル化)（methylmalonate-semialdehyde dehydrogenase (acylating)、MSDH）は、バリン・ロイシン・イソロイシン分解、イノシトール代謝、プロピオン酸代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。 2-メチル-3-オキソプロパン酸 + CoA + NAD+ プロパノイルCoA + CO2 + NADH + H+ 反応式の通り、この酵素の基質は2-メチル-3-オキソプロパン酸（メチルマロン酸セミアルデヒド）とCoAとNAD+、生成物はプロパノイルCoAとCO2とNADHとH+である。 組織名は2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)で、別名にMMSA dehydrogenaseがある。 (ja) La metilmalonato-semialdeide deidrogenasi (acilante) è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 2-metil-3-ossopropanoato + CoA + H2O + NAD+ ⇄ propanoil-CoA + HCO3- + NADH L'enzima converte anche il 3-ossopropanoato in acetil-CoA. La reazione avviene in due passaggi, con il processo di decarbossilazione che precede il legame del CoA. Come prodotto finale è rilasciato bicarbonato anziché CO2. (it) In enzymology, a methylmalonate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.27) is an enzyme that catalyzes the chemical reaction 2-methyl-3-oxopropanoate + CoA + H2O + NAD+ ⇌ propanoyl-CoA + HCO3- + NADH The 4 substrates of this enzyme are 2-methyl-3-oxopropanoate, CoA, H2O, and NAD+, whereas its 3 products are propanoyl-CoA, HCO3-, and NADH. (en) |
| rdfs:label |
Metilmalonato-semialdeide deidrogenasi (acilante) (it) メチルマロン酸セミアルデヒドデヒドロゲナーゼ (アシル化) (ja) Methylmalonate-semialdehyde dehydrogenase (acylating) (en) |
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