| dbo:abstract |
MicX sRNA (formerly known as A10) is a small non-coding RNA found in Vibrio cholerae. It was given the name MicX as it has a similar function to MicA, MicC and MicF in E. coli. MicX sRNA negatively regulates an outer membrane protein (coded for by VC0972) and also a component of an ABC transporter (gene VC0620). These interactions were predicted and then confirmed using a DNA microarray. MicX was identified through a bioinformatics screen of V. cholerae having been previously predicted. Levels of transcription of this sRNA were compared under several conditions: it was found to be expressed on all tested mediums; richer mediums slightly reduced transcription; repression of certain sigma factors (δS and δE) did not change transcription but it was dramatically reduced in the absence of Hfq protein. This observation is in accordance with other sRNA expression patterns. The MicX RNA gene overlaps with VCA0943 - a gene coding for a maltose transporter permease - but the ribonuclease RNAase E processes the MicX transcript to create an active and stable form containing only the VCA0943 3′ UTR. (en) |
| dbo:thumbnail |
wiki-commons:Special:FilePath/MicX_SScons.png?width=300 |
| dbo:wikiPageExternalLink |
https://zenodo.org/record/1235035 https://www.ncbi.nlm.nih.gov/gene/2614225 https://www.ncbi.nlm.nih.gov/gene/2615408 |
| dbo:wikiPageID |
28116311 (xsd:integer) |
| dbo:wikiPageLength |
5360 (xsd:nonNegativeInteger) |
| dbo:wikiPageRevisionID |
1043455668 (xsd:integer) |
| dbo:wikiPageWikiLink |
dbr:Membrane_protein dbr:Ribonuclease dbr:DNA_microarray dbr:Vibrio_cholerae dbr:Maltose dbc:Non-coding_RNA dbr:Transcription_(genetics) dbr:ABC_transporter dbr:E._coli dbr:Regulation_of_gene_expression dbr:Bioinformatics dbr:Hfq_protein dbr:Growth_medium dbr:Sigma_factor dbr:Non-coding_RNA dbr:Repressor dbr:Secondary_structure dbr:RNA_gene dbr:3′_UTR |
| dbp:caption |
Secondary structure of MicX sRNA. (en) |
| dbp:id |
RF01808 (en) |
| dbp:name |
MicX Vibrio cholerae sRNA (en) |
| dbp:rfam |
RF01808 (en) |
| dbp:rnaType |
sRNA (en) |
| dbp:symbol |
MicX (en) |
| dbp:taxDomain |
Vibrio cholerae (en) |
| dbp:wikiPageUsesTemplate |
dbt:Cite_journal dbt:Refbegin dbt:Refend dbt:Reflist dbt:Infobox_rfam dbt:Rfam |
| dcterms:subject |
dbc:Non-coding_RNA |
| gold:hypernym |
dbr:RNA |
| rdf:type |
dbo:Protein |
| rdfs:comment |
MicX sRNA (formerly known as A10) is a small non-coding RNA found in Vibrio cholerae. It was given the name MicX as it has a similar function to MicA, MicC and MicF in E. coli. MicX sRNA negatively regulates an outer membrane protein (coded for by VC0972) and also a component of an ABC transporter (gene VC0620). These interactions were predicted and then confirmed using a DNA microarray. (en) |
| rdfs:label |
MicX sRNA (en) |
| owl:sameAs |
freebase:MicX sRNA wikidata:MicX sRNA https://global.dbpedia.org/id/4rikT |
| prov:wasDerivedFrom |
wikipedia-en:MicX_sRNA?oldid=1043455668&ns=0 |
| foaf:depiction |
wiki-commons:Special:FilePath/MicX_SScons.png |
| foaf:isPrimaryTopicOf |
wikipedia-en:MicX_sRNA |
| is dbo:wikiPageRedirects of |
dbr:MicX |
| is dbo:wikiPageWikiLink of |
dbr:Hfq_protein dbr:Vibrio dbr:MicX |
| is foaf:primaryTopic of |
wikipedia-en:MicX_sRNA |
