Monomorphic epitheliotropic intestinal T cell lymphoma (original) (raw)
Monomorphic epitheliotropic intestinal T cell lymphoma (MEITL) (formerly termed enteropathy-associated T cell lymphoma, type II) is an extremely rare peripheral T-cell lymphoma that involves the malignant proliferation of a type of lymphocyte, the T cell, in the gastrointestinal tract (i.e. GI tract). Over time, these T cells commonly spread throughout the mucosal lining of a portion of the GI tract (particularly the jejunum and ileum of the small intestine), lead to GI tract nodules and ulcerations, and cause symptoms such as abdominal pain, weight loss, diarrhea, obstruction, bleeding, and/or perforation.
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| dbo:abstract | Monomorphic epitheliotropic intestinal T cell lymphoma (MEITL) (formerly termed enteropathy-associated T cell lymphoma, type II) is an extremely rare peripheral T-cell lymphoma that involves the malignant proliferation of a type of lymphocyte, the T cell, in the gastrointestinal tract (i.e. GI tract). Over time, these T cells commonly spread throughout the mucosal lining of a portion of the GI tract (particularly the jejunum and ileum of the small intestine), lead to GI tract nodules and ulcerations, and cause symptoms such as abdominal pain, weight loss, diarrhea, obstruction, bleeding, and/or perforation. In 2008, the World Health Organization defined a specific type of lymphoma, enteropathy-associated T cell lymphoma (EATL), as having two different types: EATL type I, a lymphoma occurring in patients with the chronic, autoimmune GI tract disorder, celiac disease, and EATL type II, a similar bowel lymphoma that was not associated with celiac disease. However, subsequent studies found significant clinical, pathologic, and pathophysiological differences between these two types of lymphoma. Consequently, the World Health Organization (2016) redefined these lymphomas as separate entities, terming the celiac disease-associated lymphoma as enteropathy-associted T cell lymphoma (EATL) and the lymphoma not associated with celiac disease as monomorphic epitheliotropic intestinal T cell lymphoma (MEITL). MEITL is only 1/5 to 1/10 as common as EATL. The Organization (2016) also termed a third type of intestinal T cell lymphoma that could not be classified as ATL or MEITL as intestinal T cell lymphoma, not otherwise specified. MEITL is a highly aggressive GI tract lymphoma which typically has had very short survival times following its diagnosis. The disease often occurs in elderly patients who are afflicted with other ailments and consequently have little tolerance for the standard chemotherapy regimens that are used to treat other types of lymphomas. Moreover, these therapeutic regimens have shown little effectiveness in treating MEITL. To date, the best but still only marginally effective therapeutic interventions for the disease have been treatments that incorporate hematopoietic stem cell transplantation into chemotherapy plus surgical (when needed to treat local bowel issues such as obstruction or perforation) regimens. (en) |
| dbo:medicalCause | dbr:T_cells |
| dbo:symptom | dbr:GI_tract |
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| dbo:wikiPageWikiLink | dbr:MAPK/ERK_pathway dbr:Anthracycline dbr:Perforin dbr:Peripheral_T-cell_lymphoma_not_otherwise_specified dbr:Cytotoxic_T_cell dbr:CD30 dbr:Indolent_T_cell_lymphoproliferative_disorder_of_the_gastrointestinal_tract dbr:Intestinal_epithelium dbr:Intestinal_villus dbr:Intraepithelial_lymphocyte dbr:JAK-STAT_signaling_pathway dbr:GNA12 dbr:Anaplasia dbr:Anaplastic_lymphoma_kinase dbr:Gastrointestinal_perforation dbr:Gastrointestinal_tract dbr:STAT5B dbr:Endoscopic dbr:Epstein–Barr_virus-encoded_small_RNAs dbr:Gastrointestinal_bleeding dbr:Bowel_obstruction dbr:Morphology_(biology) dbr:Mucosa dbr:Myc dbr:T-cell_receptors dbr:TP53 dbr:Cluster_of_differentiation dbr:Deletion_(genetics) dbr:Hematochezia dbr:Peripheral_T-cell_lymphoma dbr:Plasma_cell dbr:BRAF_(gene) dbr:CT_scan dbc:Lymphocytes dbr:Celiac_disease dbr:Transcription_factors dbr:Fusion_gene dbr:G_alpha_subunit dbr:DNMT3A dbr:Large_intestine dbr:Anaplastic_large-cell_lymphoma dbr:Duodenum dbr:Chromatin_remodeling dbr:Chromosome dbc:Lymphocytic_disorders dbr:Differential_diagnosis dbr:Granzyme_B dbr:Hispanic dbr:Epithelial dbr:Epstein-Barr_virus dbr:Epstein-Barr_virus-associated_lymphoproliferative_diseases dbr:Stomach dbr:Transcription_factor dbr:Randomized_controlled_trial dbr:Receptor_(biochemistry) dbr:HLA-DQ2 dbr:HLA-DQ8 dbr:Haplotype dbr:Hematology dbr:Hematopoietic_stem_cell_transplantation dbr:Jejunum dbr:B_cell dbr:B_symptoms dbc:Lymphoma dbc:T_cells dbc:Gastrointestinal_tract_disorders dbr:Chemotherapy dbr:KRAS dbr:T_cells dbc:Non-Hodgkin_lymphoma dbr:Bone_marrow dbr:CD28 dbr:CD3_(immunology) dbr:CD4 dbr:CD5_(protein) dbr:CD8 dbr:CDKN2A dbr:CREB-binding_protein dbr:Enteropathy-associated_T_cell_lymphoma dbr:Ileum dbr:Oncology dbr:Oropharyngeal_airway dbr:Autoimmune dbr:RHOA dbr:CDKN2B dbr:World_Health_Organization dbr:Loss_of_heterozygosity dbr:Megakaryocyte-associated_tyrosine_kinase dbr:Minisatellite dbr:Night_sweats dbr:IDH2 dbr:Immune_system dbr:Lymphocyte dbr:TIA1 dbr:Natural_killer_cell_enteropathy dbr:SETD2 dbr:Oncogene dbr:T_cell dbr:VAV1 dbr:Restriction_fragment_length_polymorphism dbr:Tumor_marker dbr:Mesenteric_lymph_nodes dbr:Intestinal_crypt dbr:JAK3 dbr:Anaplastic_large_cell_lymphoma dbr:GI_tract dbr:Loss_of_appetite dbr:Cell_surface_molecule dbr:CD56 dbr:Extranodal_NK/T_cell_lymphoma,_nasal_type dbr:NK-cell dbr:T-cells dbr:TET2 dbr:TIA-1 |
| dbp:causes | Malignant T cells (en) |
| dbp:duration | Rapidly progressive (en) |
| dbp:field | Hematology and Oncology (en) |
| dbp:name | Monomorphic epitheliotropic intestinal T cell lymphoma (en) |
| dbp:prognosis | Poor (en) |
| dbp:symptoms | GI tract symptoms (en) |
| dbp:synonyms | Enteropathy-associated T cell lymphoma, type II (en) |
| dbp:wikiPageUsesTemplate | dbt:Infobox_medical_condition_(new) dbt:Reflist |
| dct:subject | dbc:Lymphocytes dbc:Lymphocytic_disorders dbc:Lymphoma dbc:T_cells dbc:Gastrointestinal_tract_disorders dbc:Non-Hodgkin_lymphoma |
| rdf:type | owl:Thing wikidata:Q12136 dbo:Disease |
| rdfs:comment | Monomorphic epitheliotropic intestinal T cell lymphoma (MEITL) (formerly termed enteropathy-associated T cell lymphoma, type II) is an extremely rare peripheral T-cell lymphoma that involves the malignant proliferation of a type of lymphocyte, the T cell, in the gastrointestinal tract (i.e. GI tract). Over time, these T cells commonly spread throughout the mucosal lining of a portion of the GI tract (particularly the jejunum and ileum of the small intestine), lead to GI tract nodules and ulcerations, and cause symptoms such as abdominal pain, weight loss, diarrhea, obstruction, bleeding, and/or perforation. (en) |
| rdfs:label | Monomorphic epitheliotropic intestinal T cell lymphoma (en) |
| owl:sameAs | wikidata:Monomorphic epitheliotropic intestinal T cell lymphoma https://global.dbpedia.org/id/9mBZU |
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| foaf:name | Monomorphic epitheliotropic intestinal T cell lymphoma (en) |
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| is dbo:wikiPageWikiLink of | dbr:Enteropathy-associated_T-cell_lymphoma dbr:T-cell_lymphoma dbr:Natural_killer_cell_enteropathy dbr:Meitl |
| is foaf:primaryTopic of | wikipedia-en:Monomorphic_epitheliotropic_intestinal_T_cell_lymphoma |