Naloxol (original) (raw)
Naloxol is an opioid antagonist closely related to naloxone. It exists in two isomeric forms, α-naloxol and β-naloxol. α-naloxol is a human metabolite of naloxone. Synthetically, α-naloxol can be prepared from naloxone by reduction of the ketone group, and β-naloxol can be prepared from α-naloxol by a Mitsunobu reaction. Naloxol can be said to be the oxymorphol analogue of naloxone.
| Property | Value |
|---|---|
| dbo:abstract | Naloxol is an opioid antagonist closely related to naloxone. It exists in two isomeric forms, α-naloxol and β-naloxol. α-naloxol is a human metabolite of naloxone. Synthetically, α-naloxol can be prepared from naloxone by reduction of the ketone group, and β-naloxol can be prepared from α-naloxol by a Mitsunobu reaction. Naloxol can be said to be the oxymorphol analogue of naloxone. (en) ナロキソール（英語:Naloxegol）はナロキソンに類似した、オピオイドに対するアンタゴニスト（）である。α-ナロキソールとβ-ナロキソールの2つの異性体がある。α-ナロキソールはヒトがナロキソンを代謝したときに生成する物質である。α-ナロキソールはケトンを還元して合成し、β-ナロキソールはα-ナロキソールを光延反応によって変換する。 (ja) |
| dbo:iupacName | α-naloxol: (4R,4aS,7S,7aR,12bS)-3-allyl-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol (en) β-naloxol: (4R,4aS,7R,7aR,12bS)-3-allyl-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol (en) |
| dbo:thumbnail | wiki-commons:Special:FilePath/alpha-Naloxol.svg?width=300 |
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| dbo:wikiPageWikiLink | dbr:Metabolite dbc:4,5-Epoxymorphinans dbc:Allyl_compounds dbc:Human_drug_metabolites dbr:Mitsunobu_reaction dbr:Naloxegol dbr:Naloxone dbr:Opioid_antagonist dbr:Organic_redox_reaction dbc:Mu-opioid_receptor_antagonists dbr:Ketone dbr:Oxymorphol dbr:Isomer |
| dbp:imagealtl | α-naloxol (en) |
| dbp:imagealtr | β-naloxol (en) |
| dbp:imagecaptionl | α-naloxol (en) |
| dbp:imagecaptionr | β-naloxol (en) |
| dbp:imagefilel | alpha-Naloxol.svg (en) |
| dbp:imagefiler | beta-Naloxol.svg (en) |
| dbp:iupacname | α-naloxol: -3-allyl-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol (en) β-naloxol: -3-allyl-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol (en) |
| dbp:verifiedfields | changed (en) |
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| dbp:watchedfields | changed (en) |
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| dcterms:subject | dbc:4,5-Epoxymorphinans dbc:Allyl_compounds dbc:Human_drug_metabolites dbc:Mu-opioid_receptor_antagonists |
| gold:hypernym | dbr:Antagonist |
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| rdfs:comment | Naloxol is an opioid antagonist closely related to naloxone. It exists in two isomeric forms, α-naloxol and β-naloxol. α-naloxol is a human metabolite of naloxone. Synthetically, α-naloxol can be prepared from naloxone by reduction of the ketone group, and β-naloxol can be prepared from α-naloxol by a Mitsunobu reaction. Naloxol can be said to be the oxymorphol analogue of naloxone. (en) ナロキソール（英語:Naloxegol）はナロキソンに類似した、オピオイドに対するアンタゴニスト（）である。α-ナロキソールとβ-ナロキソールの2つの異性体がある。α-ナロキソールはヒトがナロキソンを代謝したときに生成する物質である。α-ナロキソールはケトンを還元して合成し、β-ナロキソールはα-ナロキソールを光延反応によって変換する。 (ja) |
| rdfs:label | ナロキソール (ja) Naloxol (en) |
| owl:sameAs | freebase:Naloxol yago-res:Naloxol wikidata:Naloxol http://azb.dbpedia.org/resource/نالوکسول dbpedia-fa:Naloxol dbpedia-ja:Naloxol dbpedia-sh:Naloxol dbpedia-sr:Naloxol https://global.dbpedia.org/id/4sFPa |
| prov:wasDerivedFrom | wikipedia-en:Naloxol?oldid=1090162036&ns=0 |
| foaf:depiction | wiki-commons:Special:FilePath/alpha-Naloxol.svg wiki-commons:Special:FilePath/beta-Naloxol.svg |
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